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Arthritis care & research 糖尿病和糖代谢异常生物标志物与偶发性影像学膝骨关节炎的相关性。

影响因子：5.178 DOI：10.1002/acr.23809

作者： Rogers-Soeder TS,Lane NE,Walimbe M,Schwartz AV,Tolstykh I,Felson DT,Lewis CE,Segal NA,Nevitt MC,Multicenter Osteoarthritis (MOST) Study Group. 发表时间：2020-07-10 19:20:33

from：《ARTHRITIS CARE & RESEARCH》

keywords： Rogers-Soeder TSLane NEWalimbe MSchwartz AVTolstykh IFelson DTLewis CESegal NANevitt MCMulticenter Osteoarthritis (MOST) Study Group.

关键词：

Abstract

OBJECTIVE:The association of diabetes mellitus (DM) with increased risk of knee osteoarthritis (OA) is uncertain. We evaluated associations of DM and biomarkers of abnormal glucose metabolism with incident radiographic knee OA, controlling for body mass index (BMI). METHODS:Participants (mean ± SD age 60.6 ± 7.8 years; mean ± SD body mass index [BMI] 29.1 ± 4.9 kg/m2 ) were from the Multicenter Osteoarthritis Study and did not have radiographic knee OA at baseline (Kellgren/Lawrence [K/L] grade <2 bilaterally). A random sample (n = 987) was selected and stratified by BMI. Baseline serum fasting glucose and homeostasis model assessment-estimated insulin resistance (HOMA-IR) were measured. Participants were categorized as having DM based on self-report, use of medication, or fasting glucose ≥126 mg/dl. Incident radiographic knee OA (K/L grade ≥2 or knee replacement) was assessed at 3 follow-up visits (30, 60, and 84 months). Knee-level pooled logistic regression analysis was performed to obtain odds ratios (ORs) (95% confidence interval [95% CI]) for associations of DM status and biomarkers of abnormal glucose metabolism with incident radiographic knee OA. RESULTS:After adjustment for BMI, the odds of incident radiographic knee OA were not associated with baseline DM status nor with levels of fasting glucose and HOMA-IR, overall and in men. In women, HOMA-IR was inversely associated with odds of incident radiographic knee OA (adjusted OR 0.80 [95% CI 0.69-0.94], P = 0.005). CONCLUSION:DM and higher levels of biomarkers of abnormal glucose metabolism were not associated with increased odds of incident radiographic knee OA after adjusting for BMI in this cohort overall. A possible protective association of higher HOMA-IR with incident radiographic knee OA in women warrants further investigation.

摘要

目的: 糖尿病 (DM) 与膝关节骨性关节炎 (OA) 风险增加的关系尚不确定。我们评估了DM和糖代谢异常生物标志物与膝关节影像学OA事件的相关性，控制体重指数 (BMI)。方法: 参与者 (平均 ± SD年龄 60.6 ± 7.8 岁; 平均 ± SD体重指数 [BMI] 29.1 ± 4.9千克/m2) 来自多中心骨关节炎研究，基线时没有影像学膝关节OA (Kellgren/Lawrence [K/L] 双侧 <2 级)。选择随机样本 (n = 987)，按BMI分层。测量基线血清空腹血糖和稳态模型评估估计的胰岛素抵抗 (HOMA-IR)。根据自我报告、药物使用或空腹血糖 ≥ 126 mg/dl，将参与者归类为DM。在 3 次随访 (30 、 60 和 84 个月) 时评估了偶然的影像学膝关节OA (K/L分级 ≥ 2 级或膝关节置换)。进行膝关节水平合并logistic回归分析以获得比值比 (ORs) (95% 置信区间 [95% CI]) DM状态和糖代谢异常生物标志物与膝关节OA发病的相关性。结果: 校正BMI后，影像学膝关节OA的发生率与基线DM状态无关，也与空腹血糖和HOMA-IR水平无关，与总体和男性无关。在女性中，HOMA-IR与放射学膝关节OA的发生率呈负相关 (校正OR 0.80 [95% CI 0.69-0.94]，P = 0.005)。结论: 在整个队列中，校正BMI后，DM和较高水平的糖代谢异常生物标志物与发生放射学膝关节OA的几率增加无关。女性较高的HOMA-IR可能与放射影像学膝关节OA的保护性相关性值得进一步研究。

期刊介绍

《ARTHRITIS CARE & RESEARCH》 (点击进入期刊详情)

英文简介 : Arthritis Care & Research, an official journal of the American College of Rheumatology and the Association of Rheumatology Health Professionals, publishes original research, review articles, and editorials that promote excellence in the clinical practice of rheumatology. Relevant to the care of individuals with rheumatic diseases, major topics are evidence-based practice studies, clinical problems, practice guidelines, educational, social, and public health issues, health economics, health care policy, and future trends in rheumatology practice.

中文简介 : （来自Google、百度翻译）关节炎护理与研究，美国风湿病学院和风湿病健康专业人员协会的官方杂志，出版了促进风湿病临床实践卓越的原始研究、评论文章和社论。与风湿病患者的护理相关，主要主题是循证实践研究、临床问题、实践指南、教育、社会和公共卫生问题、卫生经济学、卫生保健政策以及风湿病实践的未来趋势。

CIRCULATION RESEARCH 期刊中科院评价数据

新中科院分区

大类(学科)	小类(学科)	学科排名
医学	RHEUMATOLOGY (风湿病学)	9/30

新发布的期刊年发文量

年度总发文量	年度论文发表量	年度综述发表量
236	225	11

总被引频次 :16725

特征因子 : 0.024540

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