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Current diabetes reviews 糖尿病亚组中低镁血症的模式和相关因素。

影响因子： DOI：10.2174/1573399814666181026095236

作者： Rabeea IS,Al-Gburi K,Adnan I,Hasan B,Mohammed M,Mohammed M 发表时间：2020-07-10 19:20:33

keywords： Rabeea ISAl-Gburi KAdnan IHasan BMohammed MMohammed M

关键词：低镁血症糖尿病镁离子二甲双胍患者血清肌酐标准偏差。

Abstract

BACKGROUND:Nowadays, there is an accumulated data about the relation between hypomagnesemia (low Serum Mg level < 0.7 mmol/l) and diabetes. OBJECTIVE:In this study, we aimed to determine the prevalence of hypomagnesemia in a carefully diagnosed diabetes patients and to show how some factors could contribute to the prevalence of low serum Mg level among the population under study. METHODS:In short, 62 patients of both type 1 and 2, who attended AL-Sadir medical city/ diabetes and endocrinology centre during the period of the study were included in the study. A detailed history was taken and participants were informed verbally about the procedure of this study. Serum magnesium and creatinine were measured using standardized methods. RESULTS:The overall prevalence of the hypomagnesemia, among diabetic population involved in this study, was 29.03 % and it was nearly similar in male (29.41 %) and female (28.57 %). The means(SD) of serum Mg level were similar in type 1 and type 2 diabetic patients. Other difference in prevalence among other characteristics has been reported. Within all participants, gender (r = -0.02), fasting blood glucose (r = -0.514) and metformin use (r = -0.014) were negatively correlated with serum Mg level, in contrast to other variables, which were positively correlated. While among type 1 DM, age (r= 0.193), serum creatinine (r= 0.031) and insulin use (r= 0.217) were positively correlated with serum Mg level. In contrast, others were negatively correlated. In type 2 DM, age (r = -0.283) and fasting blood glucose (r = -0.496) were negatively correlated with serum Mg level. On the other hand, other variables were positively correlated with serum Mg level. CONCLUSION:Hypomagnesemia prevalence was detected in nearly one-third of the diabetic population, which is quite high prevalence. Some factors have shown to play an essential role in this prevalence. A large study is warranted to address this issue.

摘要

背景: 目前关于低镁血症 (低血镁水平 <0.7 mmol/l) 与糖尿病的关系已有大量数据积累。目的: 在这项研究中，我们旨在确定在仔细诊断的糖尿病患者中低镁血症的患病率，并展示一些因素如何导致研究人群中低血清Mg水平的患病率。方法: 总之，研究期间参加AL-Sadir medical city/糖尿病和内分泌中心的 6 2 例 1 型和 2 型患者被纳入研究。详细记录病史，并口头告知参与者本研究的程序。采用标准化方法测定血清镁和肌酐。结果: 在参与本研究的糖尿病人群中，低镁血症的总患病率为 29.03%，男性 (29.41%) 和女性 (28.57%) 几乎相似。1 型和 2 型糖尿病患者血清Mg水平均值 (SD) 相似。其他特征中患病率的其他差异也有报道。在所有参与者中，性别 (r = -0.02) 、空腹血糖 (r = -0.514) 和二甲双胍使用 (r = -0.014) 与血清Mg水平呈负相关，与其他变量相比，两者呈正相关。而在 1 型DM中，年纪 (r = 0。1 93) 、血肌酐 (r = 0.03 1) 、胰岛素使用 (r = 0.2 1 7) 与血清Mg水平呈正相关。相比之下，其他呈负相关。在 2 型DM中，年龄 (r = -0.2 83) 和空腹血糖 (r = -0.496) 与血清Mg水平呈负相关。另一方面，其他变量与血清Mg水平呈正相关。结论: 在近 3分之1 的糖尿病人群中检测到低镁血症的患病率，这是相当高的患病率。一些因素已被证明在这种流行中起着至关重要的作用。需要一项大型研究来解决这个问题。

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