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European radiology 动脉自旋标记灌注加权成像有助于预测胶质母细胞瘤的分子生物标志物和生存率。

影响因子：7.034 DOI：10.1007/s00330-019-06379-2

作者： Yoo RE,Yun TJ,Hwang I,Hong EK,Kang KM,Choi SH,Park CK,Won JK,Kim JH,Sohn CH 发表时间：2020-07-10 14:30:39

from：《EUROPEAN RADIOLOGY》

keywords： Yoo REYun TJHwang IHong EKKang KMChoi SHPark CKWon JKKim JHSohn CH

关键词：胶质母细胞瘤异柠檬酸脱氢酶总生存期灌注加权成像无进展生存期

Abstract

OBJECTIVES:Prediction of progression-free survival (PFS) and overall survival (OS) and early identification of molecular biomarkers with prognostic information are clinically important in glioblastoma (GBM) patients. We aimed to explore the utility of arterial spin labeling perfusion-weighted imaging (ASL-PWI) in the prediction of molecular biomarkers and survival in GBM patients. METHODS:We retrospectively analyzed 149 consecutive GBM patients, who had undergone maximal surgical resection or biopsy followed by concurrent chemoradiotherapy and adjuvant chemotherapy using temozolomide between November 2010 and June 2016. On preoperative ASL-PWI, cerebral blood flow (CBF) within contrast-enhancing (CE) and nonenhancing (NE) portions were evaluated both qualitatively (perfusion pattern[CE] and perfusion pattern[NE]) and quantitatively (nCBFCE and nCBFNE). ASL-PWI findings were correlated with molecular biomarkers, including isocitrate dehydrogenase (IDH) and O6-methylguanine-DNA methyltransferase (MGMT) methylation statuses, and survival, using the Mann-Whitney U-test, Spearman rank correlation, Kaplan-Meier analysis, and receiver operating characteristics analysis. RESULTS:nCBFCE was significantly higher in the IDH wild-type group than in the IDH mutant group (p = .013) and in the MGMT unmethylated group than in the methylated group (p = .047). Areas under the receiver operating characteristic curve were 0.678 for IDH mutation (p = .022) and 0.601 for MGMT promoter methylation (p = .043). Hyperperfusion was associated with the shortest median PFS for both perfusion pattern[CE] (7.6 months) and perfusion pattern[NE] (4.0 months). The perfusion pattern[NE] remained an independent predictor for PFS and OS even after adjusting for clinical and molecular predictors, unlike perfusion pattern[CE]. CONCLUSIONS:ASL-PWI can aid to predict survival and molecular biomarkers including IDH mutation and MGMT promoter methylation statuses in GBM patients. KEY POINTS:• ASL-PWI can aid to predict survival in GBM patients. • ASL-PWI can aid to predict IDH and MGMT promoter methylation statuses in GBM.

摘要

目的: 预测无进展生存期 (PFS) 和总生存期 (OS) 以及早期识别具有预后信息的分子生物标志物在胶质母细胞瘤 (GBM) 患者中具有临床重要性。我们旨在探讨动脉自旋标记灌注加权成像 (ASL-PWI) 在GBM患者分子生物标志物和生存预测中的效用。方法: 我们回顾性分析了 149 例连续GBM患者，这些患者在 2010 年 11 月至 2016 年 6 月期间接受了最大手术切除或活检，随后同步放化疗和使用替莫唑胺的辅助化疗。术前ASL-PWI，对比增强 (CE) 和非增强 (NE) 内脑血流 (CBF) 对部分进行定性 (灌注模式 [CE] 和灌注模式 [NE]) 和定量 (nCBFCE和nCBFNE) 评价。ASL-PWI结果与分子生物标志物相关，包括异柠檬酸脱氢酶 (IDH) 和O6-methylguanine-DNA甲基转移酶 (MGMT) 甲基化状态，以及生存，使用Mann-Whitney U-test，spearman等级相关、Kaplan-Meier分析和受试者工作特征分析。结果: IDH野生型组nCBFCE显著高于IDH突变组 (p =.013) MGMT未甲基化组高于甲基化组 (p =.047)。受试者工作特征曲线下面积IDH突变为 0.678 (p =.022)，MGMT启动子甲基化为 0.601 (p =.043)。灌注过度与灌注模式 [CE] (7.6 个月) 和灌注模式 [NE] (4.0 个月) 的最短中位PFS相关。与灌注模式不同，即使在调整了临床和分子预测因素后，灌注模式 [NE] 仍然是PFS和OS的独立预测因子 [CE]。结论: ASL-PWI可以帮助预测GBM患者的生存和分子生物标志物，包括IDH突变和MGMT启动子甲基化状态。要点: • ASL-PWI可以帮助预测GBM患者的生存率。•ASL-PWI可以帮助预测GBM中的IDH和MGMT启动子甲基化状态。

期刊介绍

《EUROPEAN RADIOLOGY》 (点击进入期刊详情)

英文简介 : Journal of the European Congress of Radiology (ECR) Official Organ of the European Association of Radiology (EAR) European Society of Gastrointestinal and Abdominal Radiology (ESGAR) European Society of Head and Neck Radiology (ESHNR) European Society of Musculoskeletal Radiology (ESSR) European Society of Urogenital Radiology (ESUR) European Society of Thoracic Imaging (ESTI) European Radiology (ER) was founded as the European forum of radiology. It will continuously update the scientific knowledge in radiology by the publication of excellent original papers and state-of-the-art reviews written by leading radiologists. Through its link to the European Congress of Radiology (ECR) European Radiology will improve the communication with the other journals in the world. A thorough and competent refereeing procedure will serve the authors'''''''''''''''''''''''''''''''' need for critical feedback. A well balanced combination of review articles original work short communications from the congress and information on society matters makes ER an indispensable source for current information in this field. European Radiology will be subscribed by all participants of the European Congress of Radiology and will thus reach a regular audience of several thousand readers worldwide. Publishes original articles and state-of-the-art reviews by leading radiologists Offers a balanced combination of review articles, original work, short communications and information on society matters Journal of the European Society of Radiology (ESR) Official publication of a number of professional societies 100% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again Free app available on iTunes and Google Play Store European Radiology (ER) continuously updates scientific knowledge in radiology by publication of strong original articles and state-of-the-art reviews written by leading radiologists. A well balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes ER an indispensable source for current information in this field. This is the Journal of the European Society of Radiology, and the official journal of a number of societies. From 2004-2008 supplements to European Radiology were published under its companion, European Radiology Supplements, ISSN 1613-3749.

中文简介 : （来自Google、百度翻译）欧洲国会放射学杂志》(ECR)官方机构欧洲放射学协会(EAR)欧洲社会的胃肠道和腹部放射学(ESGAR)欧洲社会的头部和颈部放射学(ESHNR)欧洲社会的肌肉骨骼放射学(几)欧洲社会的泌尿生殖放射学(ESUR)欧洲社会的胸成像(ESTI)欧洲放射学(ER)成立的欧洲放射学论坛。它将不断更新放射学的科学知识，出版优秀的原创论文和一流的放射科医生写的最先进的评论。通过与欧洲放射学大会(ECR)的联系，欧洲放射学将改善与世界其他期刊的交流。一个全面和称职的评审程序将为作者提供批判性的反馈。将来自大会的评论文章、原创作品、简短的交流以及社会问题的信息很好地结合在一起，ER成为该领域当前信息不可或缺的来源。《欧洲放射学》将由欧洲放射学大会的所有与会者订阅，因此将面向全世界的几千名经常读者。发表原创文章和先进的审查由领先的放射科医生提供一个平衡的组合，审查文章，原创作品，简短的沟通和社会问题的信息欧洲放射学会杂志(ESR) 若干专业学会的官方出版物在接受调查的作者中，100%的人表示，他们肯定会在杂志上发表文章，或者可能会再次在杂志上发表文章免费应用程序可在iTunes和谷歌播放商店欧洲放射学(ER)不断更新放射学的科学知识，出版强有力的原创文章和先进的评论，由领先的放射学家撰写。综述文章、原始论文、来自欧洲放射学大会的简短通信和关于社会问题的信息的良好平衡的结合使ER成为该领域当前信息的一个不可或缺的来源。这是欧洲放射学会的期刊，也是许多学会的官方期刊。从2004年到2008年，《欧洲放射学补编》在其同伴《欧洲放射学补编》(ISSN 1613-3749)下出版。

CIRCULATION RESEARCH 期刊中科院评价数据

新中科院分区

大类(学科)	小类(学科)	学科排名
医学	RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING (核医学)	20/129

新发布的期刊年发文量

年度总发文量	年度论文发表量	年度综述发表量
576	571	5

总被引频次 :19597

特征因子 : 0.033870

影响因子趋势图

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