gastric cancer : official journal of the international gastric cancer association and the japanese gastric cancer association-360期刊网

您当前的位置: 首页 > SCI文献 > Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 根据Lauren分类在进展期胃癌中进行浸润和外周免疫细胞分析及其预后意义。

影响因子：7.701 DOI：10.1007/s10120-019-00983-3

作者： Pernot S,Terme M,Radosevic-Robin N,Castan F,Badoual C,Marcheteau E,Penault-Llorca F,Bouche O,Bennouna J,Francois E,Ghiringhelli F,De La Fouchardiere C,Samalin E,Baptiste Bachet J,Borg C,Boige V,Voron T,Stanbury T,Tartour E,Gourgou S,Malka D,Taieb J 发表时间：2020-07-10 10:03:24

from：《Gastric Cancer》

keywords： Pernot STerme MRadosevic-Robin NCastan FBadoual CMarcheteau EPenault-Llorca FBouche OBennouna JFrancois EGhiringhelli FDe La Fouchardiere CSamalin EBaptiste Bachet JBorg CBoige VVoron TStanbury TTartour EGourgou SMalka DTaieb J

关键词：晚期胃腺癌生物标志物 CD8 + T淋巴细胞自然杀伤细胞调节性T细胞

Abstract

BACKGROUND:The correlation between immune cells and the Lauren classification subtypes and their prognostic impact in advanced gastric cancer (AGC) are unknown. METHODS:Circulating natural killer (NK) cells, CD4+ and CD8+ T cells, regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) were quantified in peripheral blood mononuclear cells (PBMCs) from 67 patients with untreated AGC enrolled in the PRODIGE 17-ACCORD 20 trial. CD56+ cells (NK), CD8+, and FoxP3+ (Treg) tumor-infiltrating lymphocytes (TILs) were assessed in tumor samples. RESULTS:Circulating NK and Treg proportions were significantly lower in patients with diffuse/mixed-type AGC (n = 27) than those with intestinal type (n = 40; median 6.3% vs 11.5%; p = 0.02 and median 3.3% vs 5.2%; p = 0.03, respectively). Proportions of circulating MDSC, CD4+ and CD8+ T cells were not associated with one pathological type. Among tumor-infiltrating cells, CD8+ T cells, but not NK or FoxP3+ cells, were significantly lower in diffuse/mixed-type AGC (median 21 vs 59 cells/field; p = 0.009). Patients with high circulating NK cell counts (> 17%) had a better overall survival than those with < 17% (HR 0.40; 95% CI [0.15-1.06]; p = 0.04). Patients with high CD8+ TIL counts (> 31 cells/field) had significantly longer overall survival (HR 0.44; 95% CI [0.21-0.92]; p = 0.02). The prognostic value of CD8+ TILs was maintained after adjustment for confounding factors, including the Lauren classification (HR = 0.42; 95% CI [0.18-0.96]; p = 0.039). CONCLUSION:Diffuse/mixed-type AGC has lower rates of CD8+ TILs and circulating NK cells and Tregs than the intestinal type. This "cold tumor" phenotype may be associated with a worse outcome.

摘要

背景: 免疫细胞和Lauren分型亚型之间的相关性及其在进展期胃癌 (AGC) 中的预后影响尚不清楚。方法: 循环自然杀伤 (NK) 细胞，CD4 + 和CD8 + T细胞，调节性T细胞 (Tregs) 和髓源性抑制细胞 (MDSCs) 在PRODIGE 17-ACCORD 20 试验中入组的 67 例未经治疗的AGC患者的外周血单核细胞 (pbmc) 中定量。在肿瘤样本中评估CD56 + 细胞 (NK) 、CD8 + 和FoxP3 + Treg (Treg) 肿瘤浸润淋巴细胞 (til)。结果: 弥漫性/混合型AGC患者循环NK和Treg比例 (n = 27) 明显低于肠道型 (n = 40); 中位数 6.3% vs 11.5%; P = 0.02 和中位数 3.3% vs 5.2%; P = 0.03)。循环MDSC、CD4 + 和CD8 + T细胞的比例与一种病理类型无关。在肿瘤浸润细胞中，CD8 + T细胞，而不是NK或FoxP3 + 细胞，在弥漫/混合型AGC中显著降低 (中位数 21 vs 59 个细胞/场; P = 0.009)。循环NK细胞计数高 (> 17%) 的患者总生存期优于 <17% (HR 0.40; 95% CI [0.15-1.06]; P = 0.04)。高CD8 + TIL计数 (> 31 个细胞/野) 的患者总生存期显著延长 (HR 0.44; 95% CI [0.21-0.92]; P = 0.02)。校正混杂因素，包括Lauren分类后，CD8 + TILs的预后价值得以维持 (hr = 0.42; 95% CI [0.18-0.96]; P = 0.039)。结论: 弥漫性/混合型AGC的CD8 + TILs和循环NK细胞和Tregs的比率低于肠型。这种 “冷瘤” 表型可能与更差的结局相关。

期刊介绍

《Gastric Cancer》 (点击进入期刊详情)

英文简介 : Published by Springer. ISSN (printed): 1436-3291. ISSN (electronic): 1436-3305. Gastric Cancer a joint official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Associat

中文简介 : （来自Google、百度翻译）由斯普林格出版。ISSN（印刷）：1436-3291。ISSN（电子版）：1436-3305。胃癌国际胃癌协会和日本胃癌协会联合官方刊物

CIRCULATION RESEARCH 期刊中科院评价数据

新中科院分区

大类(学科)	小类(学科)	学科排名
医学	GASTROENTEROLOGY & HEPATOLOGY (胃肠肝病学) ONCOLOGY (肿瘤学)	13/80 49/223

大类(学科)

小类(学科)

学科排名

医学

GASTROENTEROLOGY & HEPATOLOGY (胃肠肝病学)

ONCOLOGY (肿瘤学)

13/80
49/223

新发布的期刊年发文量

年度总发文量	年度论文发表量	年度综述发表量
127	112	15

总被引频次 :4454

特征因子 : 0.008650

影响因子趋势图

相关文献

Annals of surgery

影响因子：4.91 DOI：10.1097/SLA.0000000000003035 来源期刊：PubMed

作者：Hugenschmidt H,Labori KJ,Brunborg C,Verbeke CS,Seeberg LT,Schirmer CB,Renolen A,Borgen EF,Naume B,Wiedswang G 发表时间：2020-07-10 10:03:24

Annals of surgery

影响因子：4.91 DOI：10.1097/SLA.0000000000003084 来源期刊：PubMed

作者：Meijer LL,Garajová I,Caparello C,Le Large TYS,Frampton AE,Vasile E,Funel N,Kazemier G,Giovannetti E 发表时间：2020-07-10 10:03:24

Journal of the Formosan Medical Association = Taiwan yi zhi

影响因子：1.74 DOI：10.1016/j.jfma.2019.02.012 来源期刊：PubMed

作者：Chi CT,Chau GY,Lee RC,Chen YY,Lei HJ,Hou MC,Chao Y,Huang YH 发表时间：2020-07-10 10:03:24

Gut

影响因子：10.30 DOI：10.1136/gutjnl-2018-318021 来源期刊：PubMed

作者：Bou-Nader M,Caruso S,Donne R,Celton-Morizur S,Calderaro J,Gentric G,Cadoux M,L'Hermitte A,Klein C,Guilbert T,Albuquerque M,Couchy G,Paradis V,Couty JP,Zucman-Rossi J,Desdouets C 发表时间：2020-07-10 10:03:24

Gut

影响因子：10.30 DOI：10.1136/gutjnl-2018-316407 来源期刊：PubMed

作者：Dohan A,Gallix B,Guiu B,Le Malicot K,Reinhold C,Soyer P,Bennouna J,Ghiringhelli F,Barbier E,Boige V,Taieb J,Bouché O,François E,Phelip JM,Borel C,Faroux R,Seitz JF,Jacquot S,Ben Abdelghani M,Khemissa-Akouz F,Genet D,Jouve JL,Rinaldi Y,Desseigne F,Texereau P,Suc E,Lepage C,Aparicio T,Hoeffel C,PRODIGE 9 Investigators and PRODIGE 20 Investigators. 发表时间：2020-07-10 10:03:24

Gut

影响因子：10.30 DOI：10.1136/gutjnl-2018-318070 来源期刊：PubMed

作者：Wang R,Song S,Harada K,Ghazanfari Amlashi F,Badgwell B,Pizzi MP,Xu Y,Zhao W,Dong X,Jin J,Wang Y,Scott A,Ma L,Huo L,Vicente D,Blum Murphy M,Shanbhag N,Tatlonghari G,Thomas I,Rogers J,Kobayashi M,Vykoukal J,Estrella JS,Roy-Chowdhuri S,Han G,Zhang S,Mao X,Song X,Zhang J,Gu J,Johnson RL,Calin GA,Peng G,Lee JS,Hanash SM,Futreal A,Wang Z,Wang L,Ajani JA 发表时间：2020-07-10 10:03:24

Annals of surgery

影响因子：4.91 DOI：10.1097/SLA.0000000000003404 来源期刊：PubMed

作者：Dueland S,Syversveen T,Solheim JM,Solberg S,Grut H,Bjørnbeth BA,Hagness M,Line PD 发表时间：2020-07-10 10:03:24

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

影响因子：4.87 DOI：10.1007/s10120-019-00983-3 来源期刊：PubMed

作者：Pernot S,Terme M,Radosevic-Robin N,Castan F,Badoual C,Marcheteau E,Penault-Llorca F,Bouche O,Bennouna J,Francois E,Ghiringhelli F,De La Fouchardiere C,Samalin E,Baptiste Bachet J,Borg C,Boige V,Voron T,Stanbury T,Tartour E,Gourgou S,Malka D,Taieb J 发表时间：2020-07-10 10:03:24

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

影响因子：4.87 DOI：10.1007/s10120-019-00985-1 来源期刊：PubMed

作者：Aoyama J,Goto O,Kawakubo H,Mayanagi S,Fukuda K,Irino T,Nakamura R,Wada N,Takeuchi H,Yahagi N,Kitagawa Y 发表时间：2020-07-10 10:03:24

International journal of cancer

影响因子：6.93 DOI：10.1002/ijc.32573 来源期刊：PubMed

作者：Zanutto S,Ciniselli CM,Belfiore A,Lecchi M,Masci E,Delconte G,Primignani M,Tosetti G,Dal Fante M,Fazzini L,Airoldi A,Vangeli M,Turpini F,Rubis Passoni GG,Viaggi P,Arena M,Motta RIO,Cantù AM,Crosta C,De Roberto G,Iannuzzi F,Cassinotti A,Dall'Olio V,Tizzoni L,Sozzi G,Meroni E,Bisanti L,Pierotti MA,Verderio P,Gariboldi M 发表时间：2020-07-10 10:03:24

服务推荐

基础SCI服务

医学领域资深专家团队

临床科研服务

一对一跟进，沉淀是辅导

课题基金服务

创新思路，真实数据

SCI论文翻译润色

母语化翻译润色