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DNA损伤诱导转录物4文献资料
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DDIT4 对脑缺血再灌注损伤中自噬的调控作用
Stroke,especially ischemic stroke,is a serious threat to human health due to its high morbidity,le-thality and disability.Cerebral ischemia-reperfusion injury is an important pathophysiological process of ischemic stroke.As an important cell stress protein,DNA damage-inducible transcript 4(DDIT4)protein plays an important role in cerebral is-chemia-reperfusion injury,and it provides a new target for the study and treatment of cerebral ischemia -reperfusion injury. This review will focus on the structure and expression of DDIT 4,and its latest research progress on the regulation of auto-phagy in cerebral ischemia-reperfusion injury.
关键词： DNA损伤诱导转录物4 脑缺血再灌注损伤 自噬
