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国产固定剂量复合剂治疗初治涂阳肺结核疗效观察
固定剂量复合剂(fixed-dose combination,FDC)是将多种一线抗结核药物按照一定剂量配方制成的复方制剂,其在保证抗结核药物生物利用度的条件下,可以减少耐药菌的产生,也有利于改善医生和患者对治疗方案的适应性,是世界卫生组织推荐的结核病治疗方法,但目前由于推广力度、用药习惯、不良反应等多方面原因的影响,FDC的推广使用速度较慢[1].
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美沙酮与丁丙诺啡联用治疗海洛因依赖的临床效果
Objective:To explore the effectiveness of methadone combined with buprenorphine on the alleviation of heroin withdrawal symptoms. Methods: One hundred and twenty patients with heroin dependence were randomly divided into two groups , namely the methadone combined buprenorphine treatment group (n=60)and the methadone alone treatment group (n=60). Rating scales were employed to assess the treatment outcomes. Results: Compared with patients in the methadone alone treatment group, patients in the combined treatment group reported fewer withdrawal symptoms, especially in first four days. They also subjectively considered the combined treatment as more acceptable. This effect was more pronounced in patients with relatively high levels of initial withdrawal symptoms. Conclusion: Methadone with buprenorphine was proved to be a favourable combination treatment in terms of reducing withdrawal symptoms, as well as improving the short-term detoxification success rate, especially in patients with severe heroin withdrawal symptoms.
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ZD1839和曲妥珠单抗联合治疗对NSCLC细胞生长的协同抑制作用