首页 > 文献资料
-
多环芳烃接触者P21蛋白跟踪研究
Polycyclic Aromatic Hydrocarbons(PAHs),first determined as a sort of chemical carcinogen, can exist in chemical substance such as coal tar pitch (CTP) and coke oven volatiles (COV). The carcinogenesis of PAHs has been confirmed by epidemiological studies among high risk population and animal experiments. The excessive mortality of lung cancer has been found in workers exposed to CTP and COV. Lung cancer can be induced in rats or mice with CTP by inspiring CTP fog or intratracheal instillations. The latest advance in the study of molecular biology has been applied to the fields of occupational cancer prevention and diagnosis. The study of the amount, effect, and injury of carcinogen with biomarkers has become one of the imporant methods for the early detection for occupational lung cancer.
