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小儿精神发育迟滞合并癫痫的治疗
Objective To investigate the effective management approaches for mental retardation plus epilepsy in children.Method Sodium valproat[15~ 60 mg/( kg· day)] or nitrazepam[0.5~ 1 mg/( kg· day) ] and guanmaishu containing hyoscyamine(0.0045~ 0.045 mg/( kg· day)] as adjuvant were administered for 1.5~2 consecutive years.EEG,three dimensional Doppler ultrasonic examination of cerebral vessels were performed.Result Favorable therapeutic effect was obtained in 25 cases(48.1% ),good effect in 12 cases(23.1% ).Conclusion Favorable therapeutic effect of hyoscyamine in epilepsy is correlated with improved cerebral microcirculation,cortical choline receptor blocking ,reduced conduction between synapses.These factors all inhibit onset of epilepsy.