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多瑞吉对晚期癌痛镇痛的疗效及生存质量评估
Objective To investigate therapeutic effect of duragesic in the treatment of cancerous pain in patients with advanced tumors.Method Before entering the study,all patients suffered from moderate to severe cancerous pain.All patients were given 5 doses of duragesic within 15 days.Evaluation was performed every 12 hours.We assessed pain intensity and pain relief by using numoral rating scale(NRS).Quality of life was also evaluated.Result Eventual dose was 2.5 mg in 10 cases,5 mg in 49 cases,7.5 mg in 5 cases,10 mg in 3 cases,and 12.5 mg in 1 cases,15 mg in 1 case Complete relief was observed in 13 cases,partial relief observed in 45 cases,effective rate was 84.06% .The therapeutic effect of duragesic was similar to that of MS contin.Therapeutic effect occurred 48～ 72 hours later and became most significant 2～ 4 days later,and maintain at constant level.Conclusion By the special pattern for delivery via transdermal system,duragesic produces lasting and stable analgesic effect.In addition,it is characterized by simple operation,convenient application,insignificant adverse effects.Hence,duragesic can replace oral strong opiod drugs.
