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The New England journal of medicine 伊利诺伊州和威斯康星州与电子烟使用相关的肺部疾病-终报告。

影响因子：176.079 DOI：10.1056/NEJMoa1911614

作者： Layden JE,Ghinai I,Pray I,Kimball A,Layer M,Tenforde MW,Navon L,Hoots B,Salvatore PP,Elderbrook M,Haupt T,Kanne J,Patel MT,Saathoff-Huber L,King BA,Schier JG,Mikosz CA,Meiman J 发表时间：2020-07-14 09:42:48

from：《NEW ENGLAND JOURNAL OF MEDICINE》

keywords： Layden JEGhinai IPray IKimball ALayer MTenforde MWNavon LHoots BSalvatore PPElderbrook MHaupt TKanne JPatel MTSaathoff-Huber LKing BASchier JGMikosz CAMeiman J

关键词：

Abstract

BACKGROUND:E-cigarettes are battery-operated devices that heat a liquid and deliver an aerosolized product to the user. Pulmonary illnesses related to e-cigarette use have been reported, but no large series has been described. In July 2019, the Wisconsin Department of Health Services and the Illinois Department of Public Health received reports of lung injury associated with the use of e-cigarettes (also called vaping) and launched a coordinated public health investigation. METHODS:We defined case patients as persons who reported use of e-cigarette devices and related products in the 90 days before symptom onset and had pulmonary infiltrates on imaging and whose illnesses were not attributed to other causes. Medical record abstraction and case patient interviews were conducted with the use of standardized tools. RESULTS:There were 98 case patients, 79% of whom were male; the median age of the patients was 21 years. The majority of patients presented with respiratory symptoms (97%), gastrointestinal symptoms (77%), and constitutional symptoms (100%). All case patients had bilateral infiltrates on chest imaging. A total of 95% of the patients were hospitalized, 26% underwent intubation and mechanical ventilation, and two deaths were reported. A total of 89% of the patients reported having used tetrahydrocannabinol products in e-cigarette devices, although a wide variety of products and devices was reported. Syndromic surveillance data from Illinois showed that the mean monthly rate of visits related to severe respiratory illness in June through August of 2019 was twice the rate that was observed in the same months in 2018. CONCLUSIONS:Case patients presented with similar clinical characteristics. Although the definitive substance or substances contributing to injury have not been determined, this initial cluster of illnesses represents an emerging clinical syndrome or syndromes. Additional work is needed to characterize the pathophysiology and to identify the definitive causes.

摘要

背景: 电子烟是电池驱动的设备，加热液体并向用户提供雾化产品。与电子烟使用相关的肺部疾病已有报道，但尚未描述大型系列。2019 年 7 月，威斯康星州卫生服务部和伊利诺伊州公共卫生部门收到了与使用电子烟 (也称为vaping) 相关的肺损伤报告并发起了协调一致的公共卫生调查。方法: 我们将病例患者定义为在症状发作前 90 天内报告使用电子烟设备和相关产品，且在影像学上有肺部浸润，其疾病不归因于其他原因的人。使用标准化工具进行病历抽象和病例患者访谈。结果: 98 例患者中，男性占 79%，中位年龄 21 岁。大多数患者表现为呼吸道症状 (97%) 、胃肠道症状 (77%) 和全身症状 (100%)。所有病例在胸部影像学上都有双侧浸润。共有 95% 的患者住院治疗，26% 的患者进行了插管和机械通气，并报告了 2 例死亡病例。共有 89% 的患者报告在电子烟设备中使用了四氢大麻酚产品，尽管报告了各种各样的产品和设备。来自伊利诺伊州的综合征监测数据显示，2019 年 6 月至 8 月与严重呼吸系统疾病相关的平均每月就诊率是 2018 年相同月份观察到的就诊率的两倍。结论: 病例患者具有相似的临床特征。虽然尚未确定导致损伤的最终物质，但这一最初的疾病群代表了一种新出现的临床综合征或综合征。需要进一步的工作来描述病理生理学和确定明确的原因。

期刊介绍

《NEW ENGLAND JOURNAL OF MEDICINE》 (点击进入期刊详情)

英文简介 : One of the world's leading medical journals, the NEJM publishes original research and interpretive articles in major aspects of medicine: its science, its art and practice, and its position in today's society. Each week, The Journal presents major, previously unpublished research results, clinical findings, updates and opinions.

中文简介 : （来自Google、百度翻译）作为世界领先的医学期刊之一，《新英格兰医学杂志》在医学的科学、艺术和实践以及医学在当今社会的地位等主要方面发表原创研究和解释性文章。每周，该杂志都会发表以前未发表的主要研究成果、临床发现、最新进展和观点。

CIRCULATION RESEARCH 期刊中科院评价数据

新中科院分区

大类(学科)	小类(学科)	学科排名
医学	MEDICINE, GENERAL & INTERNAL (医学：内科)	1/155

新发布的期刊年发文量

年度总发文量	年度论文发表量	年度综述发表量
326	274	52

总被引频次 :344581

特征因子 : 0.686700

影响因子趋势图

影响因子：1.44 DOI：10.1080/14767058.2018.1488961 来源期刊：PubMed

作者：Yılmaz Semerci S,Yücel B,Erbas IM,Gunkaya OS,Talmac M,Çetinkaya M 发表时间：2020-07-14 09:42:48

Journal of the Pediatric Infectious Diseases Society

影响因子：1.82 DOI：10.1093/jpids/piy107 来源期刊：PubMed

作者：Boonyaratanakornkit J,Englund JA,Magaret AS,Bu Y,Tielsch JM,Khatry SK,Katz J,Kuypers J,Shrestha L,LeClerq SC,Steinhoff MC,Chu HY 发表时间：2020-07-14 09:42:48

Journal of the Pediatric Infectious Diseases Society

影响因子：1.82 DOI：10.1093/jpids/piy118 来源期刊：PubMed

作者：Kitt E,Drew RJ,Cunney R,Beekmann SE,Polgreen P,Butler K,Zaoutis T,Coffin SE 发表时间：2020-07-14 09:42:48

Medical mycology

影响因子：2.79 DOI：10.1093/mmy/myz015 来源期刊：PubMed

作者：Patel D,Popple S,Claydon A,Modha DE,Gaillard EA 发表时间：2020-07-14 09:42:48

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

影响因子：1.67 DOI：10.1016/j.jiac.2019.07.001 来源期刊：PubMed

作者：Igari H,Yamagishi K,Yamazaki S,Murata S,Yahaba M,Takayanagi S,Kawasaki Y,Taniguchi T 发表时间：2020-07-14 09:42:48

The Annals of thoracic surgery

影响因子：1.80 DOI：10.1016/j.athoracsur.2019.06.042 来源期刊：PubMed

作者：Stephens EH,Eltayeb O,Mongé MC,Forbess JM,Rastatter JC,Rigsby CK,Backer CL 发表时间：2020-07-14 09:42:48

European radiology

影响因子：4.08 DOI：10.1007/s00330-019-06412-4 来源期刊：PubMed

作者：Kim C,Do KH,Cha J,Song JW,Lee SM,Lee KY 发表时间：2020-07-14 09:42:48

The New England journal of medicine

影响因子：16.10 DOI：10.1056/NEJMoa1911614 来源期刊：PubMed

作者：Layden JE,Ghinai I,Pray I,Kimball A,Layer M,Tenforde MW,Navon L,Hoots B,Salvatore PP,Elderbrook M,Haupt T,Kanne J,Patel MT,Saathoff-Huber L,King BA,Schier JG,Mikosz CA,Meiman J 发表时间：2020-07-14 09:42:48

American journal of respiratory and critical care medicine

影响因子：5.24 DOI：10.1164/rccm.201904-0826OC 来源期刊：PubMed

作者：Critser PJ,Higano NS,Tkach JA,Olson ES,Spielberg DR,Kingma PS,Fleck RJ,Lang SM,Moore RA,Taylor MD,Woods JC 发表时间：2020-07-14 09:42:48

The Annals of otology, rhinology, and laryngology

影响因子：1.59 DOI：10.1177/0003489419880576 来源期刊：PubMed

作者：Patel A,Levi JR,Brook CD 发表时间：2020-07-14 09:42:48

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