high angiopoietin-2 levels associate with arterial inflammation and long-term glucocorticoid requirement in polymyalgia rheumatica.-360期刊网

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High angiopoietin-2 levels associate with arterial inflammation and long-term glucocorticoid requirement in polymyalgia rheumatica. 高angiopoietin-2 水平与风湿性多肌痛的动脉炎症和长期糖皮质激素需要量相关。

影响因子：7.046 DOI：10.1093/rheumatology/kez261

作者： van Sleen Y,Boots AMH,Abdulahad WH,Bijzet J,Sandovici M,van der Geest KSM,Brouwer E 发表时间：2020-07-10 14:05:35

from：《RHEUMATOLOGY》

keywords： van Sleen YBoots AMHAbdulahad WHBijzet JSandovici Mvan der Geest KSMBrouwer E

关键词： GCA PMR 血管生成生物标志物血管炎

Abstract

OBJECTIVES:PMR frequently co-occurs with GCA. So far, a simple biomarker for detecting concomitant arterial inflammation in PMR patients is lacking. Furthermore, biomarkers predicting disease course in PMR are awaited. We here investigated the diagnostic and prognostic value of acute-phase markers (ESR, CRP, IL-6, serum amyloid A) and angiogenesis markers (VEGF, soluble Tie2, angiopoietin-1, angiopoietin-2) in isolated PMR and PMR/GCA overlap patients. METHODS:We prospectively included 39 treatment-naïve PMR patients, of whom 10 patients also showed evidence of large vessel GCA by PET-CT. Age-matched healthy controls (n = 32) and infection controls (n = 13) were included for comparison. Serum marker levels were measured by an ELISA or Luminex assay. Receiver operating characteristic and Kaplan-Meier analyses were used to asses diagnostic and prognostic accuracy, respectively. RESULTS:All acute-phase and angiogenesis markers, except angiopoietin-1, were higher in isolated PMR patients than in healthy controls. Angiopoietin-2, ESR and soluble Tie-2 were significantly higher in patients with PMR/GCA overlap than in isolated PMR patients. Angiopoeietin-2, but not soluble Tie2, outperformed ESR and CRP in discriminating patients with and without overlapping GCA (area under the curve: 0.90; sensitivity: 100%; specificity: 76%). Moreover, high angiopoietin-2 levels were associated with long-term glucocorticoid requirement. CONCLUSION:Assessment of angiopoietin-2 at baseline may assist diagnosis of concomitant vasculitis in PMR. Moreover, high levels of angiopoietin-2 were associated with an unfavourable disease course in isolated PMR patients. These findings imply that angiopoietin-2 is an interesting diagnostic and prognostic biomarker in PMR.

摘要

目的: PMR经常与GCA共同发生。到目前为止，缺乏一种简单的生物标志物来检测PMR患者伴随的动脉炎症。此外，正在等待预测PMR病程的生物标志物。我们在这里调查了急性期标志物 (ESR、CRP、IL-6 、血清淀粉样蛋白A) 和血管生成标志物 (VEGF、可溶性Tie2 、angiopoietin-1 、angiopoietin-2) 的诊断和预后价值在孤立性PMR和PMR/GCA重叠患者中。方法: 我们前瞻性纳入了 39 例初治PMR患者，其中 10 例患者通过PET-CT也显示了大血管GCA的证据。纳入年龄匹配的健康对照 (n = 32) 和感染对照 (n = 13) 进行比较。通过ELISA或Luminex试验测量血清标志物水平。分别采用受试者工作特征和Kaplan-Meier分析评估诊断和预后准确性。结果: 孤立性PMR患者除angiopoietin-1 外，所有急性期和血管生成标志物均高于健康对照组。PMR/GCA重叠的患者Angiopoietin-2 、ESR和可溶性Tie-2 显著高于孤立性PMR患者。Angiopoeietin-2，而非可溶性Tie2，在区分GCA重叠和不重叠患者方面优于ESR和CRP (曲线下面积: 0.90; 灵敏度: 100%; 特异性: 76%)。此外，高angiopoietin-2 水平与长期需要糖皮质激素有关。结论: 基线时angiopoietin-2 的评估可能有助于PMR合并血管炎的诊断。此外，在孤立性PMR患者中，高水平的angiopoietin-2 与不利的病程相关。这些发现意味着angiopoietin-2 是PMR中一个有趣的诊断和预后生物标志物。

期刊介绍

《RHEUMATOLOGY》 (点击进入期刊详情)

英文简介 : Rheumatology (formerly the British Journal of Rheumatology) publishes original clinical laboratory and therapeutic research as well as papers on rehabilitation. In addition to many full length original research papers each issue includes editorials regular scientific reviews clinical grand rounds preliminary and brief papers viewpoints book reviews and a lively correspondence section.

中文简介 : （来自Google、百度翻译）风湿病学（原英国风湿病学杂志）出版了原始的临床实验室和治疗研究以及关于康复的论文。除了许多完整的原始研究论文外，每一期还包括社论、定期科学评论、临床大循环、初步和简要论文、观点、书评和生动的通信部分。

CIRCULATION RESEARCH 期刊中科院评价数据

新中科院分区

大类(学科)	小类(学科)	学科排名
医学	RHEUMATOLOGY (风湿病学)	5/30

新发布的期刊年发文量

年度总发文量	年度论文发表量	年度综述发表量
269	224	45

总被引频次 :19897

特征因子 : 0.029990

影响因子趋势图

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High angiopoietin-2 levels associate with arterial inflammation and long-term glucocorticoid requirement in polymyalgia rheumatica.

影响因子：3.51 DOI：10.1093/rheumatology/kez261 来源期刊：PubMed

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