发表一篇学和医学成像类SCI论文
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Abstract:
BACKGROUND AND OBJECTIVES:FTY720 ((2-amino-2-)2-[4-octylphenyl]ethyl)-1,3-propanediol) is an Food and Drug Administration (FDA)-approved immunomodulatory drug for treating multiple sclerosis. It inhibits lymphocyte egression from lymphoid tissues by downregulating sphingosine-1 phosphate receptor (S1PR). To date, there has been no study on the effects of FTY720 on the chronic stage of the complex regional pain syndrome (CRPS) rodent model, despite its antiallodynic effect in previous studies. Thus, the aim of this study is to investigate the effect of FTY720 in a chronic stage of the CRPS mouse model. METHOD:The authors used a mouse model of CRPS, involving tibia fracture/cast immobilization, to test the efficacy of intrathecal FTY720 (2.5 or 25 ng daily; 6 days) or vehicle during the chronic (7 weeks after fracture) stage of CRPS. RESULTS:Intrathecal recombinant FTY720 administration was antiallodynic in the chronic stage of the CRPS mouse model, and such an effect of FTY720 developed by modulating astrocyte activation in the spinal cord. Additionally, according to the in vitro data, the FTY720 treatment inhibited S1P-induced increase in the nitric oxide production and suppression of the NF-κB pathway, by inhibiting the phosphorylation of NF-κB/p65 in astrocytes without toxic effect on astrocytes. CONCLUSION:Collectively, these results demonstrate that intrathecally administered FTY720 attenuates mechanical allodynia in the chronic stage of the CRPS mouse model.
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最新影响因子:5.564 | 期刊ISSN:1098-7339 | CiteScore:2.71 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1998 |
自引率:20.50% | 研究方向:医学-麻醉学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Regional Anesthesia and Pain Medicine publishes original articles, clinical reports, review articles, and correspondence relevant to the practitioner concerned with local anesthetics, regional anesthesia, and pain management.
区域麻醉与疼痛医学出版与局部麻醉药、区域麻醉和疼痛管理相关的原始文章、临床报告、综述文章和通信。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ANESTHESIOLOGY(麻醉学) 2区 |
5/31 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
93 | 80 | 13 |
引文计数(2018)
文献(2015-2017)
1221次引用
451篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Anesthesiology and Pain Medicine
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研究方向:麻醉
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研究方向:疼痛
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研究方向:疼痛
影响因子:1.992
ISSN:1976-1457
研究方向:NUTRITION & DIETETICS-
影响因子:1
ISSN:0139-3006
研究方向:农林科学-食品科技
影响因子:3.221
ISSN:1654-6628
研究方向:FOOD SCIENCE & TECHNOLOGY-NUTRITION & DIETETICS
影响因子:9.298
ISSN:1930-7381
研究方向:医学-内分泌学与代谢
影响因子:4.807
ISSN:1662-4025
研究方向:医学-内分泌学与代谢
影响因子:4.725
ISSN:2044-4052
研究方向:ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
影响因子:1.417
ISSN:1575-0922
研究方向:-
影响因子:5.551
ISSN:0307-0565
研究方向:医学-内分泌学与代谢
影响因子:0.704
ISSN:0985-0562
研究方向:医学-内分泌学与代谢
发表一篇学和医学成像类SCI论文
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