Hydroxychloroquine Blood Levels Predict Hydroxychloroquine Retinopathy.

Abstract:
OBJECTIVE:In 2016, the American Academy of Ophthalmology (AAO) changed the recommended daily dose of hydroxychloroquine (HCQ) from 6.5 mg/kg to <5 mg/kg. However, it is not clear that the lower prescribed dose of HCQ will have the same efficacy for systemic lupus erythematosus (SLE) activity or the same role in protecting against cardiovascular risk factors and thrombosis. This study was undertaken to address the frequency of HCQ retinopathy and the role of HCQ blood levels in identifying those individuals who are at a greater future risk of retinopathy. METHODS:HCQ blood levels in 537 patients with SLE from a large clinical cohort were repeatedly measured, and patients were tested for HCQ retinopathy. We assessed the risk of retinopathy according to clinical characteristics and blood levels of HCQ. RESULTS:The overall frequency of retinopathy was 4.3% (23 of 537 patients). There was a 1% risk of retinopathy in the first 5 years of HCQ treatment, 1.8% from 6 to 10 years, 3.3% from 11 to 15 years, 11.5% from 16 to 20 years, and 8.0% after 21 years of use. We found that older age (P < 0.0001), higher body mass index (P for trend = 0.0160), and longer duration of HCQ intake (P = 0.0024 and P for trend = 0.0006) were associated with a higher risk of HCQ toxicity. Higher blood levels of HCQ predicted later HCQ retinopathy (P = 0.0124 and P = 0.0340 for mean and maximum HCQ blood levels, respectively). CONCLUSION:Our data prove the utility of assessing blood levels of HCQ in the prediction of retinopathy. This would allow clinicians to either decrease the dose or increase monitoring in those patients with high HCQ blood levels.
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Arthritis & Rheumatology
ARTHRITIS RHEUMATOL
最新影响因子:15.483 | 期刊ISSN:2326-5191 | CiteScore:N/A |
出版周期: | 是否OA:YES | 出版年份:0 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2326-5205
自引率:4.70% | 研究方向:RHEUMATOLOGY- |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Arthritis & Rheumatology 期刊简介
英文简介:
Arthritis & Rheumatology, an official journal of the American College of Rheumatology, is a peer-reviewed publication for scientists and clinicians interested in the natural history, pathophysiology, treatment, and outcome of the rheumatic diseases. The journal publishes the highest quality basic and clinical research related to the rheumatic diseases, encompassing a wide range of areas of investigative activity. In addition, Arthritis & Rheumatology publishes review articles, editorials, and other educational material intended for both researchers and clinicians.
中文简介:(来自Google、百度翻译)
关节炎和风湿病,美国风湿病学院的官方杂志,是一个同行评审的出版物,为科学家和临床医生感兴趣的自然历史,病理生理学,治疗和风湿病的结果。该杂志发表了与风湿性疾病相关的最高质量的基础和临床研究,涵盖了广泛的调查活动领域。此外,关节炎和风湿病出版评论文章,社论,以及其他教育材料,旨在研究人员和临床医生。
Arthritis & Rheumatology 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
医学 |
RHEUMATOLOGY(风湿病学) 2区 |
3/30 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
219 | 204 | 15 |
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文献(2015-2017)
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序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Immunology and Allergy
|
#0/170
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2 |
大类(学科):Medicine
小类(学科):Rheumatology
|
#0/53
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liting7111
研究方向:类风湿
文章刚接收,前后花了半年时间,修改了四次,大修二、小修二。对语言要求真的高,我润色了两次才通过,编辑挺实在的,对文章实用性比较看重。2020-05-14 -
liting7111
研究方向:类风湿
审的很快,可惜的是投稿被拒了。2019-08-24 -
liting7111
研究方向:骨关节炎
审稿时间: 2个月内 接受率: 比较困难(25%命中)
杂志非常专业,对工作的创新性要求很高。2019-08-03 -
liting7111
研究方向:骨关节炎 风湿
接受率: 比较困难(25%命中)
13年8月13日投稿,一个月就给了大修,还要求补实验,两个审稿人审的特别仔细,其中一个主要提了语言问题,另一个要求验证不少东西,修改半年投回去,两周编辑直接接受了。文章的创新很重要。2019-05-16
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