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Abstract:
:Buspirone presents a unique profile of action, which involves activation of 5-HT1A receptors and complex effects on D2-like dopaminergic receptors. This medication is studied in terms of potential clinical repositioning to conditions that are associated with dopaminergic dysfunctions including schizophrenia and substance use disorder. Buspirone antagonizes D3 and D4 receptors, however, depending on the dose it differentially interacts with D2 receptors. Previously, we reported that some of D2/D3 dopaminergic agonists attenuate PTSD-like behavioral symptoms in mice. Here we investigated whether buspirone could also affect PTSD-like symptoms. We used the single prolonged stress (mSPS) protocol to induce PTSD-like behavior in adult male CD-1 mice. Buspirone (0.5, 2, or 10 mg/kg, i.p.) was injected for 15 consecutive days. The subjects were repeatedly examined in a variety of behavioral tests measuring conditioned freezing response, antidepressant-like effects, anxiety, and ultrasonic vocal response to the restraint stress. Mouse SPS resulted in prolonged immobility in the forced swim test and freezing in the fear-conditioning test, and produced symptoms of anxiety. Buspirone dose-dependently decreased the exaggerated freezing response in mice, but only at the dose of 2 mg/kg exhibited the anxiolytic-like effect in the elevated plus maze test. Buspirone reduced the number of ultrasonic calls in mSPS-exposed mice but revealed no antidepressant-like effect in the forced swim test. Present data suggest some positive effects of buspirone in the treatment of selected PTSD-like symptoms and prompt for its further clinical evaluation.
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最新影响因子:3.352 | 期刊ISSN:0166-4328 | CiteScore:3.11 |
出版周期:Semimonthly | 是否OA:YES | 出版年份:1980 |
期刊官方网址:http://www.journals.elsevier.com/behavioural-brain-research/
期刊投稿地址:http://www.journals.elsevier.com/behavioural-brain-research/
自引率:5.40% | 研究方向:医学-行为科学 |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
《行为大脑研究》是一本国际性、跨学科的期刊,专门发表广义上的行为神经科学领域的文章。只要目标是描述行为背后的神经机制,来自包括神经科学、行为科学或认知科学在内的整个学科领域的贡献都是合适的。因此,研究范围可能从神经生理学、神经解剖学、神经化学或神经药理学分析脑行为关系,包括使用分子遗传学或行为遗传学方法,到涉及使用脑成像技术的研究,到神经行为学研究。报告的原始研究,主要方法的进步,或新的概念方法都是鼓励。该杂志还将考虑对选定主题的评论。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
BEHAVIORAL SCIENCES (行为科学) 3区 NEUROSCIENCES (神经科学) 3区 |
14/51 119/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
619 | 598 | 21 |
引文计数(2018)
文献(2015-2017)
5712次引用
1838篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Behavioral Neuroscience
|
#11/68
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审稿时间: 2个月内 接受率: 一般容易(75%命中)
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研究方向:神经科学 认知科学 脑疾病
审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:神经行为学 神经化学 代谢组学
接受率: 一般容易(75%命中)
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研究方向:神经医学 行为学 认知
接受率: 中等(50%命中)
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研究方向:神经科学 行为学 脑部疾病
审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:生命科学 神经科学 认知科学 心理学
审稿时间: 1个月内
影响因子:3.413
ISSN:1546-0096
研究方向:PEDIATRICS-RHEUMATOLOGY
影响因子:2.858
ISSN:0961-2033
研究方向:医学-风湿病学
影响因子:7.046
ISSN:1462-0324
研究方向:医学-风湿病学
影响因子:5.263
ISSN:1297-319X
研究方向:医学-风湿病学
影响因子:2.862
ISSN:1439-7595
研究方向:RHEUMATOLOGY-
影响因子:3.65
ISSN:0770-3198
研究方向:医学-风湿病学
影响因子:0.159
ISSN:0341-051X
研究方向:医学-风湿病学
影响因子:5.346
ISSN:0315-162X
研究方向:医学-风湿病学
影响因子:15.483
ISSN:2326-5191
研究方向:RHEUMATOLOGY-
BEHAVIOURAL BRAIN RESEARCH 投稿经验
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