发表一篇学和医学成像类SCI论文
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Abstract:
BACKGROUND & AIMS:A low muscle mass before start of treatment and loss of muscle mass during chemotherapy is related to adverse outcomes in patients with cancer. In this randomized controlled trial, the effect of nutritional counseling on change in muscle mass and treatment outcome in patients with metastatic colorectal cancer during first-line chemotherapy was studied. METHODS:Patients scheduled for first-line chemotherapy (n = 107) were randomly assigned to individualized nutritional counseling by a dietitian (NC) or usual care (UC). NC was aimed at sufficient protein- and energy intake, supported by oral supplements or enteral feeding if indicated. Furthermore, physical activity was encouraged. Outcomes were assessed at baseline (T0) and the time of the first (T1) and second (T2) regular follow-up computed tomography scans. The proportion of patients with a clinically relevant decrease in skeletal muscle area of ≥6.0 cm2, measured by computed tomography, was the primary outcome. Secondary outcomes included body weight, quality of life, treatment toxicity and progression free and overall survival. RESULTS:A total of 107 patients were enrolled (mean age, 65 years (SD, 11 years), 63% male). Mean change in skeletal muscle area from T0 till T1 was -2.5 (SD, 9.5) cm2, with no difference between NC versus UC (p = 0.891). The proportion of patients with a clinically relevant decrease in skeletal muscle area of ≥6.0 cm2 did not differ (NC 30% versus UC 31%, p = 0.467). NC compared with UC had a significant positive effect on body weight (B coefficient 1.7, p = 0.045), progression free survival (p = 0.039) and overall survival (p = 0.046). CONCLUSIONS:NC of patients undergoing chemotherapy for metastatic colorectal cancer had no effect on muscle mass. However, we found that NC may increase body weight and improve progression free survival and overall survival compared to UC in this group of patients. These findings need further evaluation in future clinical trials. CLINICAL TRIAL INFORMATION:ClinicalTrials.gov NCT01998152; Netherlands Trial Register NTR4223.
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最新影响因子:7.643 | 期刊ISSN:0261-5614 | CiteScore:4.18 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1982 |
自引率:6.50% | 研究方向:医学-营养学 |
出版地区:SCOTLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The journal publishes original articles and review papers on those factors in acute disease which have metabolic and nutritional implications, and on those features of the metabolic responses to starvation, injury and sepsis which have relevance to nutritional management. It also publishes scientific work related to the development of new techniques and their application to the care of the critically ill patient.
该杂志发表了关于急性疾病中具有代谢和营养意义的因素,以及与营养管理有关的饥饿、损伤和败血症的代谢反应特征的原始文章和综述论文。它还出版与新技术的发展及其在危重病人护理方面的应用有关的科学著作。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NUTRITION & DIETETICS (营养学) 2区 |
8/83 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
208 | 185 | 23 |
引文计数(2018)
文献(2015-2017)
2656次引用
636篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Nursing
小类(学科):Nutrition and Dietetics
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#12/112
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2 |
大类(学科):Medicine
小类(学科):Critical Care and Intensive Care Medicine
|
#6/84
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研究方向:体型指数 终点事件
审稿时间: 3个月内
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影响因子:1.992
ISSN:1976-1457
研究方向:NUTRITION & DIETETICS-
影响因子:1
ISSN:0139-3006
研究方向:农林科学-食品科技
影响因子:3.221
ISSN:1654-6628
研究方向:FOOD SCIENCE & TECHNOLOGY-NUTRITION & DIETETICS
影响因子:9.298
ISSN:1930-7381
研究方向:医学-内分泌学与代谢
影响因子:4.807
ISSN:1662-4025
研究方向:医学-内分泌学与代谢
影响因子:4.725
ISSN:2044-4052
研究方向:ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
影响因子:1.417
ISSN:1575-0922
研究方向:-
影响因子:5.551
ISSN:0307-0565
研究方向:医学-内分泌学与代谢
影响因子:0.704
ISSN:0985-0562
研究方向:医学-内分泌学与代谢
发表一篇学和医学成像类SCI论文
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