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Abstract:
BACKGROUND:For early-stage oral squamous cell carcinoma (OSCC), there is no existing risk-stratification modality beyond conventional TNM staging system to identify patients at high risk for cancer-specific mortality. METHODS:A total of 568 early-stage OSCC patients who had surgery only and also with available 5-year clinical outcomes data were identified. Signature microRNAs (miRNAs) were discovered using deep sequencing analysis and validated by qRT-PCR. The final 5-plex prognostic marker panel was utilized to generate a cancer-specific mortality risk score using the multivariate Cox regression analyses. The prognostic markers were validated in the internal and external validation cohorts. RESULTS:The risk score from the 5-plex marker panel consisting of miRNAs-127-3p, 4736, 655-3p, TNM stage and histologic grading stratified patients into four risk categories. Compared to the low-risk group, the high-risk group had 23-fold increased mortality risk (hazard ratio 23, 95% confidence interval 13-42), with a median time-to-recurrence of 6 months and time-to-death of 11 months (vs >60 months for each among low-risk patient; p
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最新影响因子:3.821 | 期刊ISSN:1043-3074 | CiteScore: |
出版周期:Monthly | 是否OA:YES | 出版年份:1989 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0347
自引率:9.30% | 研究方向:医学-耳鼻喉科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties including general surgery neurosurgery otolaryngology plastic surgery oral surgery dermatology ophthalmology pathology radiotherapy medical oncology and the corresponding basic sciences. Head & Neck publishes original contributions on clinical and research topics. Each manuscript is submitted to peer review by at least two experts in the field. Comprehensive reviews of topics particularly in fields subject to rapid change in knowledge will be included at the discretion of the Editor and on the recommendation of reviewers. Technical notes descriptions of new technologies single case reports of unusual interest and brief preliminary communications are accepted after proper peer review. Editorials and Letters to the Editor are also considered for publication. Head & Neck also publishes regular series: Controversies Basic Science Reviews Anatomic Correlates Abstracts and Book Reviews . Book Reviews are solicited by the editor and publishers should send review books to Randal S. Weber MD Editor. Visual materials will also be accepted for review. Head & Neck adheres to the Uniform Requirements for Manuscripts Submitted to Biomedical Journals under the agreement of the International Committee of Medical Journal Editors ( JAMA 1993;269:2282-2286). Manuscripts are accepted for consideration if they have not appeared elsewhere in any but abstract form and are not currently under consideration for publication elsewhere. This policy does not preclude consideration of a manuscript that has been rejected by another journal or of a complete report that follows publication of the preliminary report or abstract. It is requested that the author submit a full statement to the Editor about previous reports that may be regarded as prior or duplicate publication for the same or similar work. Multiple-part publications are discouraged. Secondary publications in another language will be considered individually. Preliminary release of data usually to public media of scientific information described in a paper may be acceptable but should be discussed with the Editor.
《头颈部》是一本关于头颈部疾病诊断和管理的原始贡献的国际多学科出版物。这一领域涉及普通外科、神经外科、耳鼻喉科、整形外科、口腔外科、皮肤科、眼科、病理学、放射治疗、医学肿瘤学和相应的基础科学等多个外科和医学专业的交叉兴趣和专长《头颈部》出版了关于临床和研究主题的原创文章。每一份手稿都由该领域至少两名专家提交同行评审。编辑可自行决定并根据评审员的建议对专题进行全面审查,尤其是在知识迅速变化的领域。在适当的同行评审后,接受新技术的技术说明、异常兴趣的单一案例报告和简短的初步沟通。社论和致编辑的信也被考虑出版。《头颈部》出版常规系列:争议基础科学评论解剖学相关摘要和书评。编辑征集书评,出版商应将评论书发送给Randal S. Weber MD编辑。视觉材料也将接受审查。根据国际医学期刊编辑委员会的协议,头颈部遵守提交给生物医学期刊的手稿的统一要求(JAMA 1993; 269:2282-2286)。如果稿件没有以任何抽象形式出现在其他地方,并且目前正在考虑在其他地方出版,则可以接受审稿。本政策不排除考虑已被其他期刊拒绝的稿件或在初步报告或摘要发布后的完整报告。要求作者向编辑提交关于之前报告的完整陈述,这些报告可能被视为相同或类似作品的先前或重复出版物。不鼓励多部分出版物。另一种语言的二级出版物将单独考虑。通常向论文中描述的科学信息的公共媒体初步发布数据可能是可以接受的,但应与编辑讨论。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
OTORHINOLARYNGOLOGY(耳鼻喉科学) 2区 SURGERY(外科学) 3区 |
9/41 65/200 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
338 | 303 | 35 |
引文计数(2018)
文献(2015-2017)
次引用
篇文献
序号 | 类别 | 排名 | 百分位 |
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审稿时间: 6个月内 接受率: 中等(50%命中)
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研究方向:医药科学 耳鼻咽喉头颈科学 嗅觉疾病 鼻疾病 前颅底疾病
审稿时间: 2个月内
影响因子:3.413
ISSN:1546-0096
研究方向:PEDIATRICS-RHEUMATOLOGY
影响因子:2.858
ISSN:0961-2033
研究方向:医学-风湿病学
影响因子:7.046
ISSN:1462-0324
研究方向:医学-风湿病学
影响因子:5.263
ISSN:1297-319X
研究方向:医学-风湿病学
影响因子:2.862
ISSN:1439-7595
研究方向:RHEUMATOLOGY-
影响因子:3.65
ISSN:0770-3198
研究方向:医学-风湿病学
影响因子:0.159
ISSN:0341-051X
研究方向:医学-风湿病学
影响因子:5.346
ISSN:0315-162X
研究方向:医学-风湿病学
影响因子:15.483
ISSN:2326-5191
研究方向:RHEUMATOLOGY-
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 投稿经验
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