发表一篇学和医学成像类SCI论文
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Abstract:
Objective The objective is to compare new bone formation in critical defects in healthy, diabetic, and osteoporotic rats filled with hydroxyapatite (HA) alone and HA combined with simvastatin (SV). Materials and methods A total of 48 adult female Sprague-Dawley rats were randomized into three groups ( n = 16 per group): Group, 1 healthy; Group 2, diabetics; and Group 3, osteoporotics. Streptozotocin was used to induce type 1 diabetes in Group 2, while bilateral ovariectomy was used to induce osteoporosis in Group 3. The central portion of the rat mandibular symphysis was used as a physiological critical bone defect. In each group, eight defects were filled with HA alone and eight with HA combined with SV. The animals were sacrificed at 4 and 8 weeks, and the mandibles were processed for micro-computed tomography to analyze radiological union and bone mineral density (BMD); histological analysis of the bone union; and immunohistochemical analysis, which included immunoreactivity of vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP-2). Results In all groups (healthy, diabetics, and osteoporotics), the defects filled with HA + SV presented greater radiological bone union, BMD, histological bone union, and more VEGF and BMP-2 positivity, in comparison with bone defects treated with HA alone. Conclusions Combined application of HA and SV improves bone regeneration in mandibular critical bone defects compared with application of HA alone in healthy, diabetic, and osteoporotic rats. Clinical relevance This study might help to patients with osteoporosis or uncontrolled diabetes type 1, but future studies should be done.
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最新影响因子:3.606 | 期刊ISSN:1432-6981 | CiteScore:2.25 |
出版周期:Quarterly | 是否OA:YES | 出版年份:1997 |
自引率:6.60% | 研究方向:医学-牙科与口腔外科 |
出版地区:GERMANY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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It is the primary aim of this international journal to be a multidisciplinary forum for publications from all fields of oral medicine. Especially it is intended to create a connection between basic and clinical sciences and thus promote the exchange of information and the advancement of oral medicine for the benefit of patients. Clinical Oral Investigations publishes original scientific articles and invited reviews which provide an international readership with up-to-date results of basic and clinical studies in the field of oral and maxillofacial science and medicine and to clarify the relevance of these results for a modern practice. Covered topics are: Maxillofacial and Oral Surgery Prosthetics and Restorative Dentistry Operative Dentistry Endodontics Periodontology Orthodontics Dental Materials Science Clinical Trials Epidemiology Pedodontics Oral Implant Preventive Dentistiry Oral Pathology Oral Basic Sciences. The submission of Case Reports is generally discouraged. Reports of animal experiments must state that the "Principles of laboratory animal care" (NIH publication No. 86-23 revised 1985) were followed as well as specific national laws (e.g. the current version of the German Law on the Protection of Animals) where applicable. The editor reserves the right to reject manuscripts that do not comply with the above-mentioned requirements. The author will be held responsible for false statements or for failure to fulfill the above-mentioned requirements.
这是本国际期刊的主要目的是成为一个多学科论坛的出版物,从所有领域的口腔医学。特别是它的目的是在基础科学和临床科学之间建立联系,从而促进信息交流和口腔医学的进步,造福于患者。临床口腔研究发表原创的科学文章,并邀请国际读者对口腔颌面科学和医学领域的基础和临床研究的最新结果进行评论,以澄清这些结果与现代实践的相关性。涵盖的课题有:颌面及口腔外科修复学、牙列外科、牙列外科、牙列牙髓学、牙周学、正畸学、牙科材料学、临床试验、流行病学、牙根学、口腔种植学、预防牙列学、口腔病理学、口腔基础科学。一般不鼓励提交病例报告。动物实验的报告必须说明“实验动物护理原则”(国立卫生研究院1985年修订本第86-23号出版物)以及适用的具体国家法律(例如德国现行的动物保护法)均得到遵守。编辑有权拒绝不符合上述要求的稿件。如有虚假陈述或不符合上述要求,作者将承担责任。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
DENTISTRY, ORAL SURGERY & MEDICINE (牙科与口腔外科) 2区 |
19/91 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
303 | 291 | 12 |
引文计数(2018)
文献(2015-2017)
1844次引用
818篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Dentistry
小类(学科):General Dentistry
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#11/114
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研究方向:医药科学 口腔颅颌面科学 口腔颌面疾病诊疗新技术
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研究方向:口腔种植
审稿时间: 12个月内
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研究方向:口腔 修复 种植
影响因子:1.992
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影响因子:4.807
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研究方向:-
影响因子:5.551
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研究方向:医学-内分泌学与代谢
影响因子:0.704
ISSN:0985-0562
研究方向:医学-内分泌学与代谢
发表一篇学和医学成像类SCI论文
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