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Abstract:
OBJECTIVE:The strongest adverse prognostic factor in myxoid/round cell liposarcomas (MRC-LPS) is the presence of a round cell component above 5% within the tumor bulk. Its identification is underestimated on biopsies and in the neoadjuvant setting. The aim was to improve the prediction of patients' prognosis through a radiomics approach. METHODS:Thirty-five out of 89 patients with MRC-LPS managed at our sarcoma reference center from 2008 to 2017 were included in this IRB-approved retrospective study as they presented with a pre-treatment contrast-enhanced MRI (median age, 49 years old). Two radiologists reported usual conventional/semantic radiological variables. After signal intensity (SI) normalization, voxel size standardization of T2-WI, and whole tumor volume segmentation, 44 3D-radiomics features were extracted. Using least absolute shrinkage and selection operator penalized Cox regression on prefiltered features, a radiomics score based on 3 weighted radiomics features was generated. Four prognostic multivariate models for MRFS were compared using concordance index: (1) clinical model, (2) semantic radiological model, (3) radiomics model, and (4) radiomics + semantic radiological model. RESULTS:Twelve patients showed a metastatic relapse. The radiomics score included FOS_Skewness, GLRLM_LRHGE, and SHAPE_Volume and correlated with MRFS (hazard ratio = 19.37, p = 0.0009) and visual heterogeneity on T2-WI (p < 0.0001). A high score indicated a poorer prognosis. After adjustment, the best predictive performances were obtained with model (4) (concordance index = 0.937) and the lowest with model (1) (concordance index = 0.637). CONCLUSION:Adding selected radiomics features that quantify tumor heterogeneity and shape at baseline to a conventional radiological analysis improves prediction of MRC-LPS patients' prognosis. KEY POINTS:• Fourteen radiomics features quantifying shape and heterogeneity of myxoid/round cell liposarcomas on T2-WI were associated with metastatic relapse in univariate analysis. • A radiomics score based on 3 selected and weighted radiomics features was a strong and independent prognostic factor for metastatic relapse-free survival. • The best prediction of metastatic relapse-free survival for myxoid/round cell liposarcomas was achieved by combining the radiomics score to relevant radiological features.
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最新影响因子:7.034 | 期刊ISSN:0938-7994 | CiteScore:4.02 |
出版周期:Monthly | 是否OA:YES | 出版年份:1991 |
期刊官方网址:http://www.springer.com/medicine/radiology/journal/330
期刊投稿地址:https://mc.manuscriptcentral.com/eurradiol?PROXY_TO_PAGE_NAME=&PRE_ACTION=&DISPLAY=&CURRENT_PAGE=LOG
自引率:13.30% | 研究方向:医学-核医学 |
出版地区:GERMANY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Journal of the European Congress of Radiology (ECR) Official Organ of the European Association of Radiology (EAR) European Society of Gastrointestinal and Abdominal Radiology (ESGAR) European Society of Head and Neck Radiology (ESHNR) European Society of Musculoskeletal Radiology (ESSR) European Society of Urogenital Radiology (ESUR) European Society of Thoracic Imaging (ESTI) European Radiology (ER) was founded as the European forum of radiology. It will continuously update the scientific knowledge in radiology by the publication of excellent original papers and state-of-the-art reviews written by leading radiologists. Through its link to the European Congress of Radiology (ECR) European Radiology will improve the communication with the other journals in the world. A thorough and competent refereeing procedure will serve the authors'''''''''''''''''''''''''''''''' need for critical feedback. A well balanced combination of review articles original work short communications from the congress and information on society matters makes ER an indispensable source for current information in this field. European Radiology will be subscribed by all participants of the European Congress of Radiology and will thus reach a regular audience of several thousand readers worldwide. Publishes original articles and state-of-the-art reviews by leading radiologists Offers a balanced combination of review articles, original work, short communications and information on society matters Journal of the European Society of Radiology (ESR) Official publication of a number of professional societies 100% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again Free app available on iTunes and Google Play Store European Radiology (ER) continuously updates scientific knowledge in radiology by publication of strong original articles and state-of-the-art reviews written by leading radiologists. A well balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes ER an indispensable source for current information in this field. This is the Journal of the European Society of Radiology, and the official journal of a number of societies. From 2004-2008 supplements to European Radiology were published under its companion, European Radiology Supplements, ISSN 1613-3749.
欧洲国会放射学杂志》(ECR)官方机构欧洲放射学协会(EAR)欧洲社会的胃肠道和腹部放射学(ESGAR)欧洲社会的头部和颈部放射学(ESHNR)欧洲社会的肌肉骨骼放射学(几)欧洲社会的泌尿生殖放射学(ESUR)欧洲社会的胸成像(ESTI)欧洲放射学(ER)成立的欧洲放射学论坛。它将不断更新放射学的科学知识,出版优秀的原创论文和一流的放射科医生写的最先进的评论。通过与欧洲放射学大会(ECR)的联系,欧洲放射学将改善与世界其他期刊的交流。一个全面和称职的评审程序将为作者提供批判性的反馈。将来自大会的评论文章、原创作品、简短的交流以及社会问题的信息很好地结合在一起,ER成为该领域当前信息不可或缺的来源。《欧洲放射学》将由欧洲放射学大会的所有与会者订阅,因此将面向全世界的几千名经常读者。 发表原创文章和先进的审查由领先的放射科医生 提供一个平衡的组合,审查文章,原创作品,简短的沟通和社会问题的信息 欧洲放射学会杂志(ESR) 若干专业学会的官方出版物 在接受调查的作者中,100%的人表示,他们肯定会在杂志上发表文章,或者可能会再次在杂志上发表文章 免费应用程序可在iTunes和谷歌播放商店 欧洲放射学(ER)不断更新放射学的科学知识,出版强有力的原创文章和先进的评论,由领先的放射学家撰写。综述文章、原始论文、来自欧洲放射学大会的简短通信和关于社会问题的信息的良好平衡的结合使ER成为该领域当前信息的一个不可或缺的来源。 这是欧洲放射学会的期刊,也是许多学会的官方期刊。 从2004年到2008年,《欧洲放射学补编》在其同伴《欧洲放射学补编》(ISSN 1613-3749)下出版。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING (核医学) 2区 |
20/129 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
576 | 571 | 5 |
引文计数(2018)
文献(2015-2017)
5400次引用
1342篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Radiology, Nuclear Medicine and Imaging
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接受率: 比较困难(25%命中)
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研究方向:abdominal dual energy
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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研究方向:介入放射 放射
审稿时间: 3个月内 接受率: 中等(50%命中)
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研究方向:急腹症 肠梗阻 胃肠道影像
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影响因子:1.714
ISSN:1386-2073
研究方向:化学-生化研究方法
影响因子:6.088
ISSN:1933-7213
研究方向:医学-神经科学
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研究方向:医学-临床神经学
影响因子:4.287
ISSN:1473-7175
研究方向:CLINICAL NEUROLOGY-PHARMACOLOGY & PHARMACY
影响因子:1.821
ISSN:1528-4336
研究方向:医学-传染病学
影响因子:2.385
ISSN:1120-009X
研究方向:医学-药学
影响因子:2.706
ISSN:1076-6294
研究方向:医学-传染病学
影响因子:4.177
ISSN:1178-6973
研究方向:-
影响因子:5.758
ISSN:0305-7453
研究方向:医学-传染病学
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