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Abstract:
:Cisplatin is used to treat a variety of solid tumors in both children and adults. However, cisplatin has serious side-effects, some of which may permanently affect patients' quality of life following treatment, such as ototoxicity. There is currently no FDA-approved therapy for the prevention or treatment of cisplatin-induced hearing loss. Herein we examine the potential for statins to prevent cisplatin-induced ototoxicity. Statins, a class of drugs commonly used to prevent or manage hypercholesterolemia, have been of clinical utility for decades with dependable outcomes and reliable safety profiles in humans. Statins are known to be protective in animal models of noise-induced and age-related hearing loss. Moreover, studies have demonstrated an additive benefit of statins in cancer treatment. In the current study, lovastatin reduces cisplatin-induced hearing loss in adult mice. Lovastatin-mediated protection was significantly greater among female than male mice, and the dose of lovastatin required for protection was different between the sexes. Taken together our data indicate that lovastatin reduces cisplatin-induced hearing loss in mice and suggest that concurrent statin and cisplatin therapy may represent a feasible clinical strategy for reducing cisplatin-induced ototoxicity that should be explored for future clinical use.
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最新影响因子:3.672 | 期刊ISSN:0378-5955 | CiteScore:2.89 |
出版周期:Monthly | 是否OA:YES | 出版年份:1978 |
期刊官方网址:http://www.journals.elsevier.com/hearing-research/
期刊投稿地址:https://www.evise.com/evise/faces/pages/login/login.jspx?resourceUrl=%2Ffaces%2Fpages%2Fnavigation%2
自引率:16.70% | 研究方向:医学-耳鼻喉科学 |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
专业编辑在线一对一答疑及时解决您的问题
The aim of the journal is to provide a forum for papers concerned with basic auditory mechanisms. Emphasis is on experimental studies, but theoretical papers will also be considered. The editor of the journal is prepared to accept original research papers in the form of full-length papers, short communications, letters to the Editor, and reviews. Papers submitted should deal with auditory neurophysiology, ultrastructure, psychoacoustics and behavioural studies of hearing in animals, and models of auditory functions. Papers on comparative aspects of hearing in animals and man, and on effects of drugs and environmental contaminants on hearing function will also be considered. Clinical papers will not be accepted unless they contribute to the understanding of normal hearing functions.
该杂志的目的是为有关基本听觉机制的论文提供一个论坛。重点是实验研究,但也将考虑理论论文。期刊的编辑准备接受原创性研究论文的形式为全文、简短的通信、给编辑的信件和评论。提交的论文应涉及听觉神经生理学、超微结构、心理声学和动物听觉行为研究,以及听觉功能模型。还将审议关于动物和人类听力的比较方面的论文,以及关于药物和环境污染物对听力功能的影响的论文。临床论文将不被接受,除非它们有助于理解正常的听力功能。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY(听力与言语-语言病理学) 2区 NEUROSCIENCES(神经系统科学) 4区 OTORHINOLARYNGOLOGY(耳鼻喉科学) 2区 |
3/25 144/261 5/41 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
202 | 179 | 23 |
引文计数(2018)
文献(2015-2017)
1458次引用
504篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Sensory Systems
|
#8/39
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影响因子:5.576
ISSN:0885-3924
研究方向:医学-临床神经学
影响因子:6.005
ISSN:0192-415X
研究方向:医学-全科医学与补充医学
影响因子:202.731
ISSN:0140-6736
研究方向:医学-医学:内科
影响因子:2.898
ISSN:1807-5932
研究方向:医学-医学:内科
影响因子:1.817
ISSN:0025-7974
研究方向:医学-医学:内科
影响因子:3.006
ISSN:2044-6055
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:0.834
ISSN:0020-9554
研究方向:医学-医学:内科
影响因子:0.522
ISSN:1108-4189
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:11.15
ISSN:1741-7015
研究方向:医学-医学:内科
发表一篇学和医学成像类SCI论文
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