Effects of Cinnamaldehyde on the Viability and Expression of Chemokine Receptor Genes in Temozolomide-treated Glioma Cells.

Abstract:
BACKGROUND/AIM:The effects of cinnamaldehyde on glioma are still unclear. We aimed to investigate the effects of cinnamaldehyde on the viability and expression of chemokine receptors CXCR4 and CXCR7 in temozolomide (TMZ)-treated glioma cells. MATERIALS AND METHODS:Cell viability and CXCR4 and CXCR7 expression were measured by western blotting at 72 h after treatment with various concentrations of cinnamaldehyde and TMZ. RESULTS:Cell viability was significantly lower after treatment with 300 μM TMZ, 50 μM cinnamaldehyde, 75 μM cinnamaldehyde, or combined treatment with 300 μM TMZ plus 50 μM or 75 μM cinnamaldehyde than after no treatment (i.e., without TMZ or cinnamaldehyde); and significantly lower after combined treatment with 300 μM TMZ plus 75 μM cinnamaldehyde but not 50 μM cinnamaldehyde, than treatment with 300 μM TMZ alone. Western blotting showed that either single treatments or combined treatments had lower CXCR4 expression (compared to the no-treatment control). Compared to 300 μM TMZ alone, both combined treatment of 300 μM TMZ plus 50 μM cinnamaldehyde or 75 μM cinnamaldehyde had significantly lowered CXCR4 expression. However, CXCR7 expression was not significantly different in all groups. CONCLUSION:Cinnamaldehyde, acting with TMZ, reduces glioma cell viability possibly via decreasing CXCR4 expression.
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IN VIVO
IN VIVO
最新影响因子:2.406 | 期刊ISSN:0258-851X | CiteScore:1.16 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:0 |
期刊官方网址:http://iv.iiarjournals.org/
期刊投稿地址:http://iv.iiarjournals.org/site/misc/submissions.xhtml
自引率:7.80% | 研究方向:医学-医学:研究与实验 |
出版地区:GREECE |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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IN VIVO 期刊简介
英文简介:
IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frame of comparative physiology and pathology. A special focus of the journal is the publication of works on: (a) Experimental development and application of new diagnostic procedures, (b) Pharmacological and toxicological evaluation of new drugs and drug combinations, (c) Development and characterization of models of biomedical research.
中文简介:(来自Google、百度翻译)
《在体》是一本国际同行评议期刊,旨在比较生理学和病理学的框架下,汇集高质量的实验和临床生物医学研究的原创作品和评论。该杂志的一个特别重点是出版下列方面的著作:(A)新诊断程序的实验发展和应用;(b)新药和药物组合的药理学和毒理学评价;(c)生物医学研究模型的发展和特征。
IN VIVO 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
医学 |
MEDICINE, RESEARCH & EXPERIMENTAL(医学,研究和试验) 4区 |
114/133 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
178 | 159 | 19 |
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IN VIVO 期刊CiteScore评价数据
最新CiteScore值
引文计数(2018)
文献(2015-2017)
484次引用
419篇文献
CiteScore排名
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):General Biochemistry, Genetics and Molecular Biology
|
#102/187
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|
|
2 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Pharmacology
|
#198/305
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|
|
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最新评论(不代表本站观点)
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liting7111
虽然分低但也不好中,投稿十天就被拒了。2020-06-05 -
liting7111
研究方向:AMH
投稿这本就是在浪费时间,半个月过去也不给意见,不如投其他的,仅供参考。2020-04-24 -
liting7111
审稿速度块,半个月就拒稿了。审稿意见简单粗暴,比较敷衍,没啥实质性作用。2020-04-10 -
liting7111
研究方向:体外实验 动物实验 药理学
审稿时间: 2个月内 接受率: 中等(50%命中)
发表比较容易,就是影响因子太低,杂志文章没什么创新性。2019-11-16
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