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Abstract:
INTRODUCTION:MicroRNAs have a significant role in the pathogenesis of preeclampsia. Circulating microRNAs could represent a potential biomarker for preeclampsia. The aim of this study was to evaluate plasma miR210-3p and miR518b in preeclampsia and healthy pregnancy for the first time by digital droplet PCR (ddPCR). METHODS:Thirty-six pregnant women (seventeen healthy pregnancies, nineteen preeclampsia patients) were involved from the Clinic for Gynaecology and Obstetrics "Narodni front" in Belgrade, Serbia. Plasma miR210-3p, miR518b and cel-miR-39 as a spike-in control were measured by ddPCR. RESULTS:MiR518b was significantly elevated in preeclampsia compared to a healthy pregnancy (P=0.034; 0.302(0.217-0.421) vs. 0.171(0.110-0.266)). MiR210-3p showed no significant difference between the two groups (P=0.951). The adjustment of miR518b was made for a gestational age and smoking status and the difference between the preeclampsia and healthy pregnancy group was more significant (P=0.026; 0.300(0.216-0.419) vs. 0.172(0.121-0.245)). Plasma miR-518b was significantly higher in the group of preeclampsia patients with proteinuria above the 75th percentile for the group (P=0.033), in women who smoked (P=0.039), and was positively related to uric acid in preeclampsia (P=0.018, r=0.536). Plasma miR518b was able to significantly discriminate between preeclampsia and healthy pregnancy, yielding AUC of 0.712 (95%CI:0.539-0.891), P=0.028. CONCLUSIONS:In this study plasma microRNA were measured for the first time in preeclampsia and healthy pregnancies with ddPCR. Placenta-specific miR-518b could serve as a potential biomarker for discriminating preeclampsia and healthy pregnancy, which should be confirmed on a larger study population. This study has failed to confirm the same potential for miR210-3p.
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最新影响因子:3.625 | 期刊ISSN:0009-9120 | CiteScore:2.35 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1967 |
期刊官方网址:http://www.journals.elsevier.com/clinical-biochemistry/
自引率:6.30% | 研究方向:医学-医学实验技术 |
出版地区:CANADA |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Clinical Biochemistry publishes articles relating to the applications of molecular biology, biochemistry, chemistry and immunology to clinical investigation and to the diagnosis, therapy, and monitoring of human disease. Manuscripts are categorized as Analytical or Clinical Investigations and may be offered as Full Papers or as Capsules. Critical Reviews are welcome, but contributors are encouraged to contact the Editor-in-Chief to avoid conflict with other forthcoming Reviews.
临床生物化学发表有关分子生物学、生物化学、化学和免疫学在临床研究、诊断、治疗和监测人类疾病中的应用的文章。手稿被分类为分析或临床调查,并可提供完整的论文或胶囊。我们欢迎批评性的评论,但也鼓励投稿者联系总编,避免与其他即将发表的评论发生冲突。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
MEDICAL LABORATORY TECHNOLOGY (医学实验技术) 3区 |
13/30 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
213 | 190 | 23 |
引文计数(2018)
文献(2015-2017)
1991次引用
846篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Clinical Biochemistry
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#52/118
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研究方向:生命科学 微生物学 病毒学
审稿时间: 2个月内
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研究方向:临床检验
审稿时间: 3个月内 接受率: 比较困难(25%命中)
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接受率: 比较困难(25%命中)
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审稿时间: 3个月内
影响因子:1.992
ISSN:1976-1457
研究方向:NUTRITION & DIETETICS-
影响因子:1
ISSN:0139-3006
研究方向:农林科学-食品科技
影响因子:3.221
ISSN:1654-6628
研究方向:FOOD SCIENCE & TECHNOLOGY-NUTRITION & DIETETICS
影响因子:9.298
ISSN:1930-7381
研究方向:医学-内分泌学与代谢
影响因子:4.807
ISSN:1662-4025
研究方向:医学-内分泌学与代谢
影响因子:4.725
ISSN:2044-4052
研究方向:ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
影响因子:1.417
ISSN:1575-0922
研究方向:-
影响因子:5.551
ISSN:0307-0565
研究方向:医学-内分泌学与代谢
影响因子:0.704
ISSN:0985-0562
研究方向:医学-内分泌学与代谢
发表一篇学和医学成像类SCI论文
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