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Abstract:
Summary Human cadaveric study has indicated that the metacarpal head (MCH) is intracapsular in location. We hypothesized that exposure to the intra-articular inflammatory milieu in psoriatic arthritis (PsA) will lead to bone loss in the MCH. Introduction To compare the bone structure and microstructure in the MCH between patients with PsA and healthy controls by high-resolution peripheral quantitative CT (HR-pQCT), and to ascertain factors associated with bone loss in PsA patients. Methods Sixty-two PsA patients without joint destruction and 62 age-, gender-, and body mass index–matched healthy subjects underwent HR-pQCT imaging of the second and third MCH (MCH 2&3). The number and volume of bone erosion and enthesiophytes, as well as volumetric bone mineral density (vBMD) and microstructure at the MCH 2&3, were recorded. Correlation analysis and multivariable linear regression models were used to determine the association of demographic and disease-specific variables with compromised bone structure and microstructure in PsA. Results At the MCH 2&3, bone erosion ( p = 0.003) and enthesiophyte ( p = 0.000) volumes in PsA patients were significantly larger than healthy controls. In PsA patients, older age was associated with a larger erosion and enthesiophyte volume. Concerning the mean vBMD and microstructure at the MCH 2&3, PsA patients had significantly lower mean vBMD (average vBMD − 6.9%, trabecular vBMD − 8.8%, peri-trabecular vBMD − 7.7%, meta-trabecular vBMD − 9.8%), trabecular bone volume fraction (− 8.8%), and trabecular thickness (− 8.1%) compared with control subjects. Multivariable regression analysis revealed that older age and a higher C-reactive protein level were associated with trabecular bone loss. Conclusions PsA patients had a higher burden of bone damages (erosions and enthesiophytes) and trabecular bone loss compared with healthy control at the MCH. Inflammation contributed to the deterioration in trabecular microstructure in these patients.
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最新影响因子:5.071 | 期刊ISSN:0937-941X | CiteScore:3.5 |
出版周期:Monthly | 是否OA:YES | 出版年份:1990 |
期刊官方网址:http://www.springer.com/medicine/orthopedics/journal/198
期刊投稿地址:http://mc.manuscriptcentral.com/oi?PROXY_TO_PAGE_NAME=&PRE_ACTION=&DISPLAY=&CURRENT_PAGE=LOGIN&SAVE_
自引率:12.00% | 研究方向:医学-内分泌学与代谢 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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An international multi-disciplinary journal which is a joint ititiative between the International Osteoporosis and the National Osteoporosis Foundation of the USA the journal provides the journal a forum for the communication and exchange of current ideas concerning osteoporosis. It publishes: original papers - reporting progress and results in all areas of osteoporosis and its related fields; review articles - reflecting the present state of knowledge in special areas of summarizing limited themes in which discussion has led to clearly defined conclusions; educational articles - giving information on the progress of a topic of particular interest; case reports - of uncommon or interesting presentations of the condition; correspondence - concerning matters of topical interest or relating to publisher's material; book reviews; reports of meetings; Society announcements; etc.
《骨质疏松》是国际骨质疏松症基金会与美国国家骨质疏松症基金会联合创办的国际性多学科期刊,为当前有关骨质疏松症的学术交流提供了一个平台。它出版:原始论文-报告骨质疏松症及其相关领域的所有领域的进展和结果;审查文章-反映在总结已导致明确界定结论的有限主题的特定领域的知识现状;教育性文章-就特别感兴趣的课题的进展情况提供资料;病例报告-罕见或有趣的症状表现;与时事有关或与出版商资料有关的信件;书评;会议报告;社会公告;等。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ENDOCRINOLOGY & METABOLISM (内分泌学与代谢) 3区 |
40/142 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
348 | 306 | 42 |
引文计数(2018)
文献(2015-2017)
3859次引用
1101篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Endocrinology, Diabetes and Metabolism
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#40/209
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研究方向:骨质疏松
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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接受率: 中等(50%命中)
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研究方向:脊柱外科内固定研发 骨质疏松 骨代谢
接受率: 比较困难(25%命中)
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研究方向:医药科学 运动系统 骨、关节、软组织退行性病变
审稿时间: 2个月内
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研究方向:骨代谢临床文章
审稿时间: 3个月内
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研究方向:医药科学 内分泌系统 骨代谢异常 骨质疏松
审稿时间: 1个月内
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研究方向:骨科 内分泌
审稿时间: 2个月内
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研究方向:医药科学
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研究方向:orthopeaqdics
影响因子:1.992
ISSN:1976-1457
研究方向:NUTRITION & DIETETICS-
影响因子:1
ISSN:0139-3006
研究方向:农林科学-食品科技
影响因子:3.221
ISSN:1654-6628
研究方向:FOOD SCIENCE & TECHNOLOGY-NUTRITION & DIETETICS
影响因子:9.298
ISSN:1930-7381
研究方向:医学-内分泌学与代谢
影响因子:4.807
ISSN:1662-4025
研究方向:医学-内分泌学与代谢
影响因子:4.725
ISSN:2044-4052
研究方向:ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
影响因子:1.417
ISSN:1575-0922
研究方向:-
影响因子:5.551
ISSN:0307-0565
研究方向:医学-内分泌学与代谢
影响因子:0.704
ISSN:0985-0562
研究方向:医学-内分泌学与代谢
发表一篇学和医学成像类SCI论文
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