
发表一篇学和医学成像类SCI论文
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Abstract:
:The Chinese patent medicine She-Xiang-Xin-Tong-Ning (SXXTN) is a clinical medication for coronary heart disease (CHD) and angina pectoris. This study aimed to investigate pharmacological effects of SXXTN and elucidate the role in angiogenesis on human umbilical vein endothelial cells (HUVECs) and acute myocardial ischemia (AMI) rats. We prepared SXXTN to treat the cells to reveal their effects on oxidative stress-damaged cell viability, as well as cell proliferation, migration, and tube formation processes. SXXTN was also used to treat coronary artery ligation-induced acute myocardial ischemia rats to confirm whether it had positive effect on myocardial issues by hematoxylin and eosin (HE), 2,3,5-triphenyltetrazolium chloride (TTC) staining and immunohistochemical staining. We measured the levels of peroxidative damage-related enzymes in cytoplasm and serum by biochemical kits and detected vascular endothelial growth factor (VEGF), angiotensin II (Ang II), thromboxane B2 (TXB2), and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 α ) levels in cells and rats by enzyme-linked immunosorbent assay (ELISA) kits. The results showed that SXXTN protects HUVECs against oxidative stress damage and reversed the decrease of superoxide dismutase (SOD), glutathione (GSH) and increase of creatine kinase (CK), lactate dehydrogenase (LDH) caused by oxidative stress. SXXTN promoted angiogenesis through stimulating cell migration, tube formation, and activating VEGF/VEGFR2 and ERK1/2 pathways. Furthermore, SXXTN reduced infarct size and inhibited PGI2/TXA2 imbalance, preventing atherosclerosis plaque rupture leading to worsening coronary heart disease. Taken together, we report the first in vivo and in vitro evidence that SXXTN reduced oxidative stress-mediated damage and enhanced angiogenesis, which might be useful in treatment of myocardial infarction.
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最新影响因子:6.005 | 期刊ISSN:0192-415X | CiteScore:3.05 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1979 |
自引率:29.70% | 研究方向:医学-全科医学与补充医学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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AMERICAN JOURNAL OF CHINESE MEDICINE
美国中医杂志
大类(学科) | 小类(学科) | 学科排名 |
医学 |
INTEGRATIVE & COMPLEMENTARY MEDICINE (全科医学与补充医学) 2区 MEDICINE, GENERAL & INTERNAL (医学:内科) 2区 |
3/27 31/155 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
96 | 87 | 9 |
引文计数(2018)
文献(2015-2017)
889次引用
291篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Complementary and Alternative Medicine
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研究方向:中医
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研究方向:中医治疗 中药开发 民族医学
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影响因子:3.413
ISSN:1546-0096
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研究方向:RHEUMATOLOGY-
AMERICAN JOURNAL OF CHINESE MEDICINE 投稿经验
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