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抗M抗体、抗Lea抗体以及自身冷抗体引起的输血交叉配血不合1例
Irregular antibody refers to blood type antibody except ABO blood group antibody.Irregular antibodies can cause hemolytic transfusion reaction and destroy the red blood cells or shorten theirs life,then affect the effect of blood transfusion and even life-threatening.Therefore,it is very important to have clinical blood typing and irregular antibody screening.This center laboratory found 1 case combined anti-M antibodies,anti-Lea antibodies and cold autoantibodies which caused blood cross-matching incompatibility before blood transfusion antibody screening experiment.
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自身抗体伴有Lea同种抗体肾肿瘤手术大量输血1例
1 病例简介患者,女,45岁,肾巨大肿瘤准备手术,有妊娠史、输血史;血红蛋白44 g/L,血型O型,Rh阳性,抗体筛查阳性,送入本血站要求不规则抗体鉴定及配合性血液筛查.
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76例Lewis血型抗体血清学特征及其对输血相容性检测的影响
目的 探讨Lewis血型系统抗体的血清学特征及其对输血相容性检测结果的影响和处理方法.方法 采用微柱凝胶法对临床送检的患者血标本进行ABO及Rh血型鉴定,采用Liss/Coombs卡进行不规则抗体筛选及交叉配血试验,对抗体筛选阳性及交叉配血不合的血标本采用微柱凝胶法和盐水试管法进行抗体特异性鉴定,对有特异性抗体者采用盐水试管法进行Lewis血型抗原检测.结果 在76例Lewis血型抗体中,抗Lea抗体75例(98.7％),抗Leb抗体1例(1.3％);男26例(34.2％),女50例(65.8％),女性患者抗体阳性率明显高于男性.76例Lewis血型抗体在盐水试管法中出现凝集76例(100％),在Liss/Coombs卡中出现凝集72例(94.7％),Lewis血型抗原检测均为Lea-b-.76例Lewis血型抗体在抗体筛选及交叉配血中均出现凝集,13例在ABO血型反定型中出现凝集.盐水试管法凝集强度为1+以下～1+(22℃),Liss/Coombs卡凝集强度为混合外观凝集至1+以下(37℃),抗体类型为IgM型.结论 产生Lewis血型抗体的血型抗原均为Lea-b-;Lewis血型抗体可干扰输血相容性检测结果,采用盐水试管法和Liss/Coombs卡联合检测可提高对Lewis血型抗体的检出率.
