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摘要: Objective: This study aims to explore the association between the density of Himalayan marmot (Marmota himalayana) and climatic factors such as temperature, precipitation, humidity, vapour pressure, sunshine percentage, wind velocity, which are closely associated with global climate change, and to provide a reference for plague prevention and control. Methods: We conducted a regression analysis to find the possible climate factors associated with the density of Himalaya marmot, and analyzed the response characters of Himalayan marmot to climate change. Results:Daily precipitation days (>=0.1 mm) and sunshine percentage were significantly associated with the density of Himalayan marmot ( p<0.01). Conclusion:Climate change was associated with the risk of plague. This phenomenon is valuable for Himalayan marmot and plague prevention. More studies are needed to understand the impact of climate change on Himalayan marmot and plague.

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  • The dielectric properties in vitro present characteristic changes along with the alteration of metabolic activities, which can be detected from tissue micro-structure. The dielectric properties of tissues are closely related to its viability, but the relationship remains unclear to us. This study aims to specify the relationship between dielectric parameters and microstructure of living tissues and to try to explain the influence of tissue viability on dielectric properties. Nine rabbits were studied in this experiment. The impedance spectroscopy (10 Hz-1 MHz) and microstructure were determined at different time intervals (from 5 min to 7 h) after samples were prepared. Some characteristic parameters were extracted to analyze the relationship between them. The inactivation process characterized by the microstructurs could be detected by means of dielectric parameters:the microstructures had no obvious change within 30 min and cell swelling caused by osmosis led to the decrease of extracellular ion concentration, resulting in the rise of lowfrequency imped ance after 30 min. The reduction of impedance was accompanied by the expanding intercellular area and irregular cell shape caused by the gradual destruction of cell membrane.The functions between alteration rate of intercellular area and Cole-Cole model parameters were also established. There is a strong correlative relationship between dielectric properties and microstructure. The dielectric spectrum can be a rapid and innocuous method to monitor the status of tissues. In the future, it may be of great help for clinical application, especially in transplantation.

  • Objective:To investigate the influence of different right ventricular (RV) pacing sites on QRS width, and to provide a potential reference site for permanent right ventricular pacing in patients implanted with permanent pacemakers. Pacing at the site with the shortest QRS duration may reduce the deleterious effects of RV pacing on LV function, and thus having beneficial effects on patient's outcome. Methods: All consecutive patients who were planned to have permanent pacemaker implantation for a Class I or IIa indication at our department from October 2010 to July 2012 were screened for the participation in this prospective, single center, non-randomized study. The baseline surface ECG was analyzed for QRS width and morphology, respectively. During the implantation procedure patients were transiently paced at different RV locations (right ventricular apex, right ventricular inflow tract [RVIT], mid septum, high septum and right ventricular outflow tract [RVOT]) before the lead was placed at its final position. During pacing at the different positions the surface 12-leads ECG was recorded. Based on the surface of ECG QRS duration and morphology of the different right ventricular pacing sites were analyzed and compared with baseline and to each other. Results: A total of 216 patients (39% female, mean age 69 ± 13 years, higher degree AV block 30.5%) was enrolled in the study. Paced QRS duration was significantly different between all right ventricular pacing sites compared with the baseline ECG (baseline:106 ms±21 ms;mean paced:158 ms±16 ms;p<0.001). RVA pacing showed the widest QRS (168 ms±16 ms). QRS duration with RVIT pacing was 166 ms±15 ms, and that with RVOT pacing was 165 ms ± 15 ms, respectively. QRS duration was not significantly different between these three positions. Mid-septal pacing showed the narrowest QRS (139 ms±19 ms) compared to all other pacing sites (p<0.001). Pacing at the high-septum showed a broader QRS (153 ms ± 14 ms) than that pacing at the mid-
    septum. Compared to other right ventricular pacing sites, QRS morphology at the mid-septum was close to normal, and electrical axis was unchanged as compared to baseline. Conclusion: Pacing at different right ventricular sites showed the significant widening of QRS compared to baseline. The shortest QRS duration was seen with mid-septal pacing. Therefore, mid-septal pacing may have less deleterious effect on LV function compared to other RV pacing locations, which may be the optimal right ventricular pacing site in permanent pacemaker recipients.

  • How to design clinical trials for medical devices is a problem plaguing the industry today. As there are many differences in clinical trials of medical devices and drugs. This paper describes the differences of the two points from the perspectivs of defi-nition of medical devices and drugs, scope, phasing, subjects and design of clinical trials in details, aiming to help the related personnel make scientific decisions while conduct-ing clinical trial design for medical devices.

  • In order to listen to brain activity as a piece of music, we proposed a scale-free brainwave music (SFBM) technology, which translates the scalp EEG into music notes according to the power law of both EEG and music. In this paper, the methodology was further extended to chorus music of two channels from the two hemispheres. Firstly, EEG data from two channels symmetrically located on the left and right hemispheres are translated into MIDI sequences by SFBM, respectively, where the EEG parameters modulate the pitch, duration and volume of each music note. Then, the two sequences are fiitered into a chorus of the Chinese pentatonic scale or the Western major scale. The resulted Chinese and Western music at different sleep stages illustrate distinct differences in harmony, and the music with Chinese pentatonic scale sounds more harmonious.

  • Objective: This study aims to explore the association between the density of Himalayan marmot (Marmota himalayana) and climatic factors such as temperature, precipitation, humidity, vapour pressure, sunshine percentage, wind velocity, which are closely associated with global climate change, and to provide a reference for plague prevention and control. Methods: We conducted a regression analysis to find the possible climate factors associated with the density of Himalaya marmot, and analyzed the response characters of Himalayan marmot to climate change. Results:Daily precipitation days (>=0.1 mm) and sunshine percentage were significantly associated with the density of Himalayan marmot ( p<0.01). Conclusion:Climate change was associated with the risk of plague. This phenomenon is valuable for Himalayan marmot and plague prevention. More studies are needed to understand the impact of climate change on Himalayan marmot and plague.

  • To effectively suppress white noise and preserve more useful components of electrocardiogram (ECG) signal, a novel de-noising method based on morphological component analysis (MCA) is proposed. MCA is a method which allows us to separate features contained in an original signal when these features present different morphological aspects. According to the features of ECG, we used the UWT dictionary to sparsely represent mutated component, and used the DCT dictionary to sparsely represent smooth component. The experimental results of the samples choosing from MIT-BIH databases show that the MCA-based method is effective for white noise removal.

  • A new wavelet variance analysis method based on window function is proposed to investigate the dynamical features of electroencephalogram (EEG).The ex-prienmental results show that the wavelet energy of epileptic EEGs are more discrete than normal EEGs, and the variation of wavelet variance is different between epileptic and normal EEGs with the increase of time-window width. Furthermore, it is found that the wavelet subband entropy (WSE) of the epileptic EEGs are lower than the normal EEGs.

  • In this paper, an approach to the design of hemispherical breast RF coil array is proposedThe target field method is applied to find the current density distribution on the hemisphere surface, which induces a homogeneous magnetic field in a hemispherical volumeThe components of current density are expanded into Fourier series, and the highly ill-conditioned character of the linear equation related to Fourier coefficients is solved using the Tikhonov regularization method with a minimum curvature penalty functionThe winding pattern was acquired using the stream function techniqueThe results indicate that a simple winding pattern with homogeneous magnetic field can be obtained through manually selecting the penalty factor.

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