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您当前的位置:   首页  >  SCI文献  >  Zoledronic acid inhibits thyroid cancer stemness and metastasis by repressing M2-like tumor-associated macrophages induced Wnt/β-catenin pathway.

Zoledronic acid inhibits thyroid cancer stemness and metastasis by repressing M2-like tumor-associated macrophages induced Wnt/β-catenin pathway.
影响因子：6.78 DOI：10.1016/j.lfs.2020.117925
作者： Lv J,Chen FK,Liu C,Liu PJ,Feng ZP,Jia L,Yang ZX,Hou F,Deng ZY 发表时间：2020-09-10 01:41:12
from：《LIFE SCIENCES》
keywords： Lv JChen FKLiu CLiu PJFeng ZPJia LYang ZXHou FDeng ZY
关键词：
Abstract
AIMS:This study aims to explore the effect and underlying mechanism of zoledronic acid (ZA) on the incidence of thyroid cancer (TC) tumorigenesis. MATERIALS AND METHODS:Human mononuclear cells THP-1 were differentiated into M2-like tumor associated macrophages (TAMs) by incubation with PMA followed by additional incubation of IL-4 and IL-13. TC cells TPC-1 and IHH4 were co-cultured with M2-like TAMs. Identification of M2-like TAMs markers were determined by immunohistochemistry or flow cytometry. Cell proliferation, stemness and migration/invasion ability were measured by colony, sphere formation assay and transwell assay, respectively. The expression levels of cell stemness, EMT and Wnt/β-catenin pathway-related factors were verified by qRT-PCR, Western blotting, and immunofluorescence. A subcutaneous tumor model was established in nude mice to examine the in vivo effects of ZA. KEY FINDINGS:M2-like TAMs were enriched in TC tissues, and they promoted the colony/sphere formation, accompanied with a down-regulated expression in E-cadherin and an up-regulated expression in N-cadherin, Vimentin and other stemness-associated markers (CD133, Oct4, c-Myc) in TC cells. The effects were suppressed when ZA co-treatment was given, because ZA inhibited the polarization of M2-like TAMs and β-catenin entry into the nucleus. Moreover, in agreement with in vitro data, ZA also limited subcutaneous tumor formation and macrophage enrichment in nude mice. SIGNIFICANCE:ZA suppressed M2-like TAMs induced TC cell proliferation, stemness and metastasis through inhibiting M2-like TAMs polarization and Wnt/β-catenin pathway, which sheds light on the mechanisms of TC and provides avenues for the development of clinical therapy to TC.
摘 要
期刊介绍
《LIFE SCIENCES》 (点击进入期刊详情)
英文简介 : Life Sciences is an international weekly journal publishing reports on research in biomedical areas. Articles are encouraged that emphasize the molecular, cellular and functional aspects of Cardiovascular & Autonomic Mechanisms; Drug Metabolism; Endocrinology; Growth Factors and Neoplasia; Immunology; Neuroscience and Toxicology. The Journal publishes original research rapidly. Although full-length manuscripts are favored, shorter submissions are also considered. These shorter articles must be of the same high quality as full-length articles, and should contain information from topical and fast-moving fields in order to merit more rapid communication. Mini-reviews on topics of wide interest to investigators in the life sciences are also published. All articles are rigorously reviewed. The Journal favors publication of papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research.
中文简介 : （来自Google、百度翻译） 《生命科学》是一份国际周刊，出版生物医学领域的研究报告。鼓励强调心血管和自主机制的分子、细胞和功能方面的文章;药物代谢;内分泌学;生长因子与肿瘤;免疫学;神经学和毒理学。该杂志迅速发表原创研究。虽然全篇幅的稿件更受欢迎，但也可以考虑提交较短的稿件。这些较短的文章必须与完整的文章具有相同的高质量，并且应该包含来自主题和快速移动领域的信息，以便进行更快速的交流。对生命科学研究人员广泛感兴趣的主题也发表了小型评论。所有文章都经过严格审查。该杂志倾向于发表现代科学技术用于解释分子、细胞和生理机制的论文。仅仅报告观察结果的文章很少被接受。必须遵守《赫尔辛基宣言》或国家卫生研究院关于护理和使用实验室动物的指导方针的建议。文章应该写在对文章主题本身不是专家，但对研究感兴趣的读者能够理解的水平上。
CIRCULATION RESEARCH 期刊中科院评价数据
新中科院分区
大类(学科) 小类(学科) 学科排名
医学

MEDICINE, RESEARCH & EXPERIMENTAL (医学：研究与实验)

PHARMACOLOGY & PHARMACY (药学)

53/133
78/261
新发布的期刊年发文量
年度总发文量 年度论文发表量 年度综述发表量
337 287 50

总被引频次 :21687

特征因子 : 0.016400

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