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您当前的位置:   首页  >  SCI文献  >  Coronary atherosclerosis scoring with semiquantitative CCTA risk scores for prediction of major adverse cardiac events: Propensity score-based analysis of diabetic and non-diabetic patients.

Coronary atherosclerosis scoring with semiquantitative CCTA risk scores for prediction of major adverse cardiac events: Propensity score-based analysis of diabetic and non-diabetic patients.
影响因子:3.814 DOI:10.1016/j.jcct.2019.11.015
作者: van den Hoogen IJ,van Rosendael AR,Lin FY,Lu Y,Dimitriu-Leen AC,Smit JM,Scholte AJHA,Achenbach S,Al-Mallah MH,Andreini D,Berman DS,Budoff MJ,Cademartiri F,Callister TQ,Chang HJ,Chinnaiyan K,Chow BJW,Cury RC,DeLago A,Feuchtner G,Hadamitzky M,Hausleiter J,Kaufmann PA,Kim YJ,Leipsic JA,Maffei E,Marques H,de Araújo Gonçalves P,Pontone G,Raff GL,Rubinshtein R,Villines TC,Gransar H,Jones EC,Peña JM,Shaw LJ,Min JK,Bax JJ 发表时间:2020-09-09 00:18:16
keywords: van den Hoogen IJvan Rosendael ARLin FYLu YDimitriu-Leen ACSmit JMScholte AJHAAchenbach SAl-Mallah MHAndreini DBerman DSBudoff MJCademartiri FCallister TQChang HJChinnaiyan KChow BJWCury RCDeLago AFeuchtner GHadamitzky MHausleiter JKaufmann PAKim YJLeipsic JAMaffei EMarques Hde Araújo Gonçalves PPontone GRaff GLRubinshtein RVillines TCGransar HJones ECPeña JMShaw LJMin JKBax JJ
关键词:
Abstract
AIMS:We aimed to compare semiquantitative coronary computed tomography angiography (CCTA) risk scores - which score presence, extent, composition, stenosis and/or location of coronary artery disease (CAD) - and their prognostic value between patients with and without diabetes mellitus (DM). Risk scores derived from general chest-pain populations are often challenging to apply in DM patients, because of numerous confounders. METHODS:Out of a combined cohort from the Leiden University Medical Center and the CONFIRM registry with 5-year follow-up data, we performed a secondary analysis in diabetic patients with suspected CAD who were clinically referred for CCTA. A total of 732 DM patients was 1:1 propensity-matched with 732 non-DM patients by age, sex and cardiovascular risk factors. A subset of 7 semiquantitative CCTA risk scores was compared between groups: 1) any stenosis ≥50%, 2) any stenosis ≥70%, 3) stenosis-severity component of the coronary artery disease-reporting and data system (CAD-RADS), 4) segment involvement score (SIS), 5) segment stenosis score (SSS), 6) CT-adapted Leaman score (CT-LeSc), and 7) Leiden CCTA risk score. Cox-regression analysis was performed to assess the association between the scores and the primary endpoint of all-cause death and non-fatal myocardial infarction. Also, area under the receiver-operating characteristics curves were compared to evaluate discriminatory ability. RESULTS:A total of 1,464 DM and non-DM patients (mean age 58 ± 12 years, 40% women) underwent CCTA and 155 (11%) events were documented after median follow-up of 5.1 years. In DM patients, the 7 semiquantitative CCTA risk scores were significantly more prevalent or higher as compared to non-DM patients (p ≤ 0.022). All scores were independently associated with the primary endpoint in both patients with and without DM (p ≤ 0.020), with non-significant interaction between the scores and diabetes (interaction p ≥ 0.109). Discriminatory ability of the Leiden CCTA risk score in DM patients was significantly better than any stenosis ≥50% and ≥70% (p = 0.003 and p = 0.007, respectively), but comparable to the CAD-RADS, SIS, SSS and CT-LeSc that also focus on the extent of CAD (p ≥ 0.265). CONCLUSION:Coronary atherosclerosis scoring with semiquantitative CCTA risk scores incorporating the total extent of CAD discriminate major adverse cardiac events well, and might be useful for risk stratification of patients with DM beyond the binary evaluation of obstructive stenosis alone.
摘 要
期刊介绍
《Journal of Cardiovascular Computed Tomography》 (点击进入期刊详情)
英文简介 : The Journal of Cardiovascular Computed Tomography is a unique peer-review journal that integrates the entire international cardiovascular CT community including cardiologist and radiologists, from basic to clinical academic researchers, to private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our cardiovascular imaging community across the world. The goal of the journal is to advance the field of cardiovascular CT as the leading cardiovascular CT journal, attracting seminal work in the field with rapid and timely dissemination in electronic and print media. The Journal addresses a broad range of topics that affect cardiovascular CT imaging. Our major focus is on original research and on the clinical and technical aspects of cardiovascular CT. Other sections include Contemporary and Historical Reviews, unique Case Reports, Viewpoints, Practical Tips and Tricks, Images with videos viewable on the Internet, Guidelines, Editorial Commentaries, Basic/Clinical Implications, Historical Vignettes and news developments in cardiovascular CT. As the Official Journal of the Society of Cardiovascular CT, we also publish the Plenary address given at the annual Scientific Sessions of SCCT each summer. We publish position papers and important news information for SCCT members about the Society, and supplement issues, including the abstracts from the Annual Scientific Session. To encourage and promote excitement in performing research, each year we recognize leading clinicians and researchers, and recognize outstanding cardiology and four outstanding radiology trainees for their work in the field. The Editorial Board includes internationally prominent individuals who are devoted to advancement of the science of cardiovascular CT.
中文简介 : (来自Google、百度翻译) 心血管计算机断层扫描是一种独特的同行评议的期刊杂志,集成了整个国际心血管CT社区包括心脏病医生和放射科医生,从基础到临床学术研究者,私人医生,工程师,盟军的专业人士,工业,和学员,都是至关重要的和相互依存的全球心血管成像社区的成员。该杂志的目标是推动心血管CT领域成为领先的心血管CT杂志,通过电子和印刷媒体的快速、及时的传播,吸引该领域的开创性工作。 该杂志涉及广泛的主题,影响心血管CT成像。我们主要专注于心血管CT的原始研究和临床及技术方面。其他部分包括当代和历史回顾、独特的病例报告、观点、实用提示和技巧、可在互联网上观看的视频图像、指南、编辑评论、基本/临床含义、历史小插曲和心血管CT的新闻发展。作为心血管CT学会的官方期刊,我们还在每年夏天的SCCT科学年会上发表全体演讲。 我们为SCCT会员发表关于社会的立场论文和重要新闻信息,并补充问题,包括年度科学会议摘要。 为了鼓励和促进人们对研究工作的热情,我们每年都会表彰杰出的临床医生和研究人员,并表彰在该领域工作的优秀心脏病学和四名优秀放射学实习生。 编辑委员会包括致力于心血管CT科学发展的国际知名人士。
CIRCULATION RESEARCH 期刊中科院评价数据
新中科院分区
大类(学科) 小类(学科) 学科排名
医学

CARDIAC & CARDIOVASCULAR SYSTEMS(心脏和心血管系统)

RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING(放射学,核医学和医学成像)

50/128
31/129
新发布的期刊年发文量
年度总发文量 年度论文发表量 年度综述发表量
80 79 1

总被引频次 :1711

特征因子 : 0.004430

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