the potential of cbc-derived ratios (monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte) to predict or diagnose incident tb infection in tanzanian adolescents.-360期刊网

您当前的位置: 首页 > SCI文献 > The potential of CBC-derived ratios (monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte) to predict or diagnose incident TB infection in Tanzanian adolescents.

The potential of CBC-derived ratios (monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte) to predict or diagnose incident TB infection in Tanzanian adolescents.

影响因子：3.667 DOI：10.1186/s12879-020-05331-w

作者： Rees CA,Pineros DB,Amour M,Munseri P,Said J,Magohe A,Matee M,Pallangyo K,von Reyn CF 发表时间：2020-08-31 00:56:35

from：《BMC INFECTIOUS DISEASES》

keywords： Rees CAPineros DBAmour MMunseri PSaid JMagohe AMatee MPallangyo Kvon Reyn CF

关键词：

Abstract

BACKGROUND:Ratios of different immune cell populations (i.e., monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte ratios) have been studied as a means of predicting future tuberculosis (TB) disease risk or to assist in the diagnosis of incident TB disease. No studies to-date, however, have evaluated the potential of these ratios to predict or assist in the diagnosis of incident TB infection - the first step in the natural history of TB disease. METHODS:In this prospective study, we evaluated the complete blood count (CBC)-derived metrics of monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) as predictors of future TB infection risk or aids in the diagnosis of TB infection among 145 Tanzanian adolescents enrolled in the DAR-901 vaccine trial, using paired CBCs and interferon-gamma release assays (IGRAs) obtained at 0, 60 and 720 days after study enrollment. RESULTS:At baseline, there were no significant differences between study participants who remained persistently IGRA negative throughout the study period and those who subsequently converted to IGRA positive with respect to MLR (0.18 vs 0.17, p = 0.10), NLR (0.88 vs 1.02, p = 0.08), or PLR (115 vs 120, p = 0.28). Similarly, no significant differences were noted with respect to MLR, NLR, and PLR between IGRA converters and time-matched negative controls at the time of IGRA conversion. With respect to other blood cell measures, however, there were modest but significant differences between IGRA negatives and IGRA converters with respect to red blood cell count (4.8 vs 4.6 × 106 cells/mcL, p = 0.008), hemoglobin (12.6 vs 12.3 g/dL, p = 0.01), and hematocrit (38.8 vs 37.8%, p = 0.005). CONCLUSIONS:In contrast to prior studies that have suggested that the ratios of different immune cell populations are associated with development of TB disease, our present findings do not demonstrate an association between these ratios and the development of TB infection. However, decreased red blood cell measures were associated with the subsequent development of TB infection, suggesting either that dysregulation of iron metabolism may play a role in TB pathogenesis or that following TB infection, iron dysregulation may precede IGRA positivity. TRIAL REGISTRATION:Clinicaltrials.gov NCT02712424 . Date of registration: March 14, 2016.

摘要

期刊介绍

《BMC INFECTIOUS DISEASES》 (点击进入期刊详情)

英文简介 : Published by BioMed Central. ISSN: 1471-2334. BMC Infectious Diseases publishes original research articles in all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases, as well as related molecular genetics, pathophysiology, and epidemiology.

中文简介 : （来自Google、百度翻译）由生物医学中心出版。ISSN: 1471 - 2334。 BMC传染病在传染病和性传播疾病的预防、诊断和管理，以及相关的分子遗传学、病理生理学和流行病学的所有方面发表原创研究文章。

CIRCULATION RESEARCH 期刊中科院评价数据

新中科院分区

大类(学科)	小类(学科)	学科排名
医学	INFECTIOUS DISEASES (传染病学)	44/88

新发布的期刊年发文量

年度总发文量	年度论文发表量	年度综述发表量
794	746	48

总被引频次 :15284

特征因子 : 0.045880

影响因子趋势图

相关文献

AIDS and behavior

影响因子：3.10 DOI：10.1007/s10461-019-02436-5 来源期刊：PubMed

作者：Tran L,Tran P,Tran L 发表时间：2020-07-10 17:30:33

AIDS and behavior

影响因子：3.10 DOI：10.1007/s10461-019-02431-w 来源期刊：PubMed

作者：Cheng W,Egan JE,Liu Q,Xu H,Stall R,Friedman MR 发表时间：2020-07-10 17:30:33

AIDS and behavior

影响因子：3.10 DOI：10.1007/s10461-019-02449-0 来源期刊：PubMed

作者：Hall BJ,Yang X,Huang L,Yi G,Chan EWW,Tucker JD,Latkin CA 发表时间：2020-07-10 17:30:33

Journal of the American Academy of Dermatology

影响因子：2.93 DOI：10.1016/j.jaad.2019.02.074 来源期刊：PubMed

作者：Forrestel AK,Kovarik CL,Katz KA 发表时间：2020-07-10 17:30:33

AIDS and behavior

影响因子：3.10 DOI：10.1007/s10461-019-02524-6 来源期刊：PubMed

作者：Bantjes J,Kagee A,Saal W 发表时间：2020-07-10 17:30:33

AIDS and behavior

影响因子：3.10 DOI：10.1007/s10461-019-02517-5 来源期刊：PubMed

作者：Aronson ID,Cleland CM,Rajan S,Marsch LA,Bania TC 发表时间：2020-07-10 17:30:33

AIDS and behavior

影响因子：3.10 DOI：10.1007/s10461-019-02516-6 来源期刊：PubMed

作者：Janssen R,Engel N,Esmail A,Oelofse S,Krumeich A,Dheda K,Pai NP 发表时间：2020-07-10 17:30:33

Laboratory medicine

影响因子：0.85 DOI：10.1093/labmed/lmz021 来源期刊：PubMed

作者：Gannett MS,Gammon RR 发表时间：2020-07-10 17:30:33

AIDS care

影响因子：2.12 DOI：10.1080/09540121.2019.1619663 来源期刊：PubMed

作者：Felsen UR,Torian LV,Futterman DC,Stafford S,Xia Q,Allan D,Esses D,Cunningham CO,Weiss JM,Zingman BS 发表时间：2020-07-10 17:30:33

Laboratory medicine

影响因子：0.85 DOI：10.1093/labmed/lmz029 来源期刊：PubMed

作者：Fei F,Marques MB,Staley EM,Williams LA 发表时间：2020-07-10 17:30:33

服务推荐

基础SCI服务

医学领域资深专家团队

临床科研服务

一对一跟进，沉淀是辅导

课题基金服务

创新思路，真实数据

SCI论文翻译润色

母语化翻译润色