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DNA vaccine protection against SARS-CoV-2 in rhesus macaques.

影响因子：63.714 DOI：10.1126/science.abc6284

作者： Yu J,Tostanoski LH,Peter L,Mercado NB,McMahan K,Mahrokhian SH,Nkolola JP,Liu J,Li Z,Chandrashekar A,Martinez DR,Loos C,Atyeo C,Fischinger S,Burke JS,Slein MD,Chen Y,Zuiani A,Lelis FJN,Travers M,Habibi S,Pessaint L,Van Ry A,Blade K,Brown R,Cook A,Finneyfrock B,Dodson A,Teow E,Velasco J,Zahn R,Wegmann F,Bondzie EA,Dagotto G,Gebre MS,He X,Jacob-Dolan C,Kirilova M,Kordana N,Lin Z,Maxfield LF,Nampanya F,Nityanandam R,Ventura JD,Wan H,Cai Y,Chen B,Schmidt AG,Wesemann DR,Baric RS,Alter G,Andersen H,Lewis MG,Barouch DH 发表时间：2020-08-29 00:53:23

from：《SCIENCE》

keywords： Yu JTostanoski LHPeter LMercado NBMcMahan KMahrokhian SHNkolola JPLiu JLi ZChandrashekar AMartinez DRLoos CAtyeo CFischinger SBurke JSSlein MDChen YZuiani ALelis FJNTravers MHabibi SPessaint LVan Ry ABlade KBrown RCook AFinneyfrock BDodson ATeow EVelasco JZahn RWegmann FBondzie EADagotto GGebre MSHe XJacob-Dolan CKirilova MKordana NLin ZMaxfield LFNampanya FNityanandam RVentura JDWan HCai YChen BSchmidt AGWesemann DRBaric RSAlter GAndersen HLewis MGBarouch DH

关键词：

Abstract

:The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made the development of a vaccine a top biomedical priority. In this study, we developed a series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 spike (S) protein and evaluated them in 35 rhesus macaques. Vaccinated animals developed humoral and cellular immune responses, including neutralizing antibody titers at levels comparable to those found in convalescent humans and macaques infected with SARS-CoV-2. After vaccination, all animals were challenged with SARS-CoV-2, and the vaccine encoding the full-length S protein resulted in >3.1 and >3.7 log10 reductions in median viral loads in bronchoalveolar lavage and nasal mucosa, respectively, as compared with viral loads in sham controls. Vaccine-elicited neutralizing antibody titers correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate vaccine protection against SARS-CoV-2 in nonhuman primates.

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大类(学科)	小类(学科)	学科排名
综合性期刊	MULTIDISCIPLINARY SCIENCES (综合性期刊)	2/64

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年度总发文量	年度论文发表量	年度综述发表量
769	702	67

总被引频次 :680994

特征因子 : 1.070190

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