Fatality of Staphylococcus aureus infections in a Greek university hospital: role of inappropriate empiric treatment, methicillin resistance, and toxin genes' presence.

Abstract:
:The aim of the present study was to identify predictors of fatality among patients with S. aureus infections requiring hospitalization. Cases hospitalized with S. aureus infections at the University General Hospital of Patras, Greece, during a 4-year period (2013-2016) were studied. mecA, lukS/lukF-PV (Panton-Valentine leukocidin, PVL), tst (toxic shock syndrome toxin), fnbA (fibronectin-binding protein A), eta, and etb (epidermolytic toxins) genes' carriage was detected by PCR in 149 selected patients. Among 464 patients, 346 were included (118 with missing data). Primary bacteremia predominated (44.2%), followed by lower respiratory tract infections (13.6%), deep seated infections (9.8%), osteoarticular (9.5%), and catheter-related bloodstream infections (6.1%). Methicillin-resistant S. aureus (MRSA) represented 33.8% of infections and were less likely to receive appropriate empiric treatment (79.5% versus 97.4%; P < 0.001). Thirty-day fatality was 14.5%. Multivariate analysis revealed that development of septic shock, Charlson Comorbidity Index, lower respiratory tract infection, bacteremia (primary or secondary), MRSA, and CRP was significantly associated with fatality. Appropriate empiric treatment was a predictor of good prognosis. Thirty-two out of 149 S. aureus (21.5%) carried lukS/lukF-PV genes, whereas, 14 (9.4%), 133 (78.7%), four (2.7%), and one (0.7%) carried tst, fnbA, eta, and etb genes, respectively. No difference was found among toxin genes' presence and mortality. PVL was significantly more frequently found among MRSA as compared to MSSA (45.1% versus 9.2%; P < 0.001). MRSA represented one third of the infections requiring hospitalization and were independently associated with fatality, probably since were more likely to receive inappropriate antibiotic treatment as compared to MSSA.
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EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
EUR J CLIN MICROBIOL
最新影响因子:5.103 | 期刊ISSN:0934-9723 | CiteScore:N/A |
出版周期:Monthly | 是否OA:YES | 出版年份:1988 |
期刊官方网址:http://www.springer.com/biomed/medical+microbiology/journal/10096
自引率:6.10% | 研究方向:医学-传染病学 |
出版地区:GERMANY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 期刊简介
英文简介:
EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin. The journal welcomes full articles presenting original research results, invited editorials, and reviews on the following topics: General epidemiology and diagnostics of infectious agents Clinical infectious diseases research Genetics and phenotypes of host susceptibility towards infectious disease or colonization Use of animal models to study bacterial infections and the imaging of such infections Studies should primarily be performed from a mechanistic point of view with emphasis on the inter-relatedness of molecular features with clinical presentation of infections. Papers on the translational application of basic research findings will be prioritized.
中文简介:(来自Google、百度翻译)
EJCMID是一本跨学科的杂志,致力于出版关于细菌、病毒和寄生虫起源的传染病的通讯。 欢迎就以下课题发表完整的原创研究成果、邀请发表评论和评论: 传染病病原体的一般流行病学和诊断 临床传染病研究 宿主对传染病或定殖的易感性的遗传学和表型 利用动物模型研究细菌感染和此类感染的影像学 研究应主要从机械学的角度进行,强调分子特征与感染临床表现的相互关系。基础研究成果转化应用的论文将优先发表。
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
生物 |
INFECTIOUS DISEASES(传染病) 4区 MICROBIOLOGY(微生物学) 3区 |
47/88 63/126 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
303 | 277 | 26 |
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EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 期刊CiteScore评价数据
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引文计数(2018)
文献(2015-2017)
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序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Immunology and Microbiology
小类(学科):Microbiology
|
#0/135
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2 |
大类(学科):Medicine
小类(学科):Microbiology (medical)
|
#0/109
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liting7111
研究方向:微生物 肠道微生物
比较喜欢投的杂志,如果能上3分就好了。2020-06-25 -
liting7111
研究方向:微生物 肠道微生物
问下大家,这杂志对格式和语言要求高吗?之前投了几次,感觉投稿指南太繁杂了,要求太多,已经不想再修改了。2020-06-25 -
liting7111
研究方向:微生物 肠道微生物
审稿时间: 1个月内
因为文章研究方向与杂志主体不符合,投稿一周就被编辑拒稿了。2020-05-25 -
liting7111
研究方向:微生物 支原体 不孕不育
审稿时间: 2个月内 接受率: 中等(50%命中)
请教下,杂志需要版面费吗?今天收到确认信息open access publishing charge is USD 3000/EUR 2200 ,是否所在院校和杂志签过协议就可以免版面费?求指导2020-04-12 -
liting7111
研究方向:微生物 肠道微生物
编辑很认真负责,审稿花了不到两个月,修回后第二天就接收了,效率很高,但是今年更难投了。2019-12-18 -
liting7111
研究方向:微生物 肠道微生物
审稿时间: 1个月内 接受率: 一般容易(75%命中)
投稿一个月,小修之后就被收了,很nice,不过现在影响因子下降了。2019-12-15 -
liting7111
谁有这本杂志的投稿链接?求2019-06-08 -
liting7111
审稿时间: 2个月内 接受率: 中等(50%命中)
效率还是挺高的,编辑挺负责的,不很有耐心。2019-03-09 -
liting7111
研究方向:微生物 肠道微生物
审稿时间: 1个月内 接受率: 中等(50%命中)
速度很快,投稿一个月左右要求小修,修回后一天就接收了,挺高兴的2019-03-08 -
liting7111
研究方向:微生物 肠道微生物
投稿两天,被拒了,理由是文章研究内容过于基础,跟临床的相关性不是很大。2019-02-02
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