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Abstract:
Background Infectious meningitis is a serious disease and patient outcome relies on fast and reliable diagnostics. A syndromic panel testing approach like the FilmArray ME can accelerate diagnosis and therefore decrease the time to pathogen specific therapy. Yet, its clinical utility is controversial, mainly because of a remaining uncertainty in correct interpretation of results, limited data on its performance on clinical specimens and its relatively high costs. The aim of this study was to analyze clinical performance of the assay in a real life setting at a tertiary university hospital using a pragmatic and simple sample selection strategy to reduce the overall cost burden. Methods Over a period of 18 months we received 4623 CSF samples (2338 hospitalizations, 1601 individuals). FilmArray ME analysis was restricted to CSF-samples with a high pretest probability of infectious meningitis, e.g. positive Gram-stain, samples in which leukocytes and/or bacteria were evident or urgent suspicion of infection was communicated by clinicians. N = 171 samples matched to our risk criteria and were subjected to FilmArray ME analysis. Those samples were also analyzed by reference methods: culture only (n = 45), PCR only (n = 20) or both methods (n = 106). Results 56/171 (32.75%) were FilmArray ME positive. Bacterial pathogens were detected in 30/56 (53.57%), viral pathogens were detected in 27/56 (48.21%) and yeast DNA was detected in 1/56 (1.79%) of positive samples. Double detection occurred in 2/56 samples. In 52/56 (92.86%) FilmArray ME positive samples, results could be confirmed by the reference assays (sensitivity = 96.30%, specificity =96.58%). Conclusion The FilmArray ME assay is a fast and reliable diagnostic tool for the management of infectious meningitis and can easily be implemented in routine diagnostic workflows. However, correlation of test results and underlying clinical symptoms requires experienced users and the awareness of potentially false negative or false positive results. Moreover, considering the need for antimicrobial susceptibility testing, the use of molecular tests as a stand-alone diagnostic cannot be recommended.
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最新影响因子:3.667 | 期刊ISSN:1471-2334 | CiteScore:2.86 |
出版周期:Irregular | 是否OA:YES | 出版年份:2001 |
自引率:4.70% | 研究方向:医学-传染病学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published by BioMed Central. ISSN: 1471-2334. BMC Infectious Diseases publishes original research articles in all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases, as well as related molecular genetics, pathophysiology, and epidemiology.
由生物医学中心出版。ISSN: 1471 - 2334。 BMC传染病在传染病和性传播疾病的预防、诊断和管理,以及相关的分子遗传学、病理生理学和流行病学的所有方面发表原创研究文章。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
INFECTIOUS DISEASES (传染病学) 3区 |
44/88 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
794 | 746 | 48 |
引文计数(2018)
文献(2015-2017)
6069次引用
2124篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Infectious Diseases
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#64/266
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研究方向:免疫
审稿时间: 6个月内 接受率: 比较困难(25%命中)
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接受率: 一般容易(75%命中)
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研究方向:感染
审稿时间: 3个月内 接受率: 中等(50%命中)
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研究方向:肝病 免疫
审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:感染与免疫
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研究方向:肺损伤 缺血缺氧脑病
审稿时间: 2个月内 接受率: 一般容易(75%命中)
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审稿时间: 3个月内 接受率: 中等(50%命中)
影响因子:1.714
ISSN:1386-2073
研究方向:化学-生化研究方法
影响因子:6.088
ISSN:1933-7213
研究方向:医学-神经科学
影响因子:1.379
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研究方向:医学-临床神经学
影响因子:4.287
ISSN:1473-7175
研究方向:CLINICAL NEUROLOGY-PHARMACOLOGY & PHARMACY
影响因子:1.821
ISSN:1528-4336
研究方向:医学-传染病学
影响因子:2.385
ISSN:1120-009X
研究方向:医学-药学
影响因子:2.706
ISSN:1076-6294
研究方向:医学-传染病学
影响因子:4.177
ISSN:1178-6973
研究方向:-
影响因子:5.758
ISSN:0305-7453
研究方向:医学-传染病学
发表一篇学和医学成像类SCI论文
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