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发表一篇学和医学成像类SCI论文
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Abstract:
BACKGROUND:The presentation of clinical leptospirosis has been historically associated with animal workers, slaughterhouse workers and medical veterinarians. This association has shifted to be related to flooding events and outdoor activities; few cases are related to high-risk factors found in immunosuppressed patients. Scarcely a handful of cases have serological evidence of immune response against Leptospira serovar Bratislava representing serogroup Australis, a serovar associated with poor reproductive performance in swine and horses, and recently with cats. CASE PRESENTATION:Herein, we describe a rare clinical presentation of disseminated Leptospira infection in an immunosuppressed 65-year-old woman. She was admitted to the emergency room with fever, bacteraemia, bilateral uveitis and pulmonary involvement. The patient denied outdoor activities; she only had wide exposure to faeces and urine from cats living in her home. Her medical history included idiopathic thrombocytopenic purpura (ITP) diagnosed at the age of 18. She did not respond to medical treatment, and a splenectomy was performed. At age 60, she was diagnosed with Chronic Myeloid Leukemia (CML), and was treated with a tyrosine kinase inhibitor (TKI) -Imatinib. The patient voluntarily discontinued the treatment for the last 6 months. After extensive workup, no microorganisms were identified by the commonly used stains in microbiology. The diagnosis was performed through dark-field microscopy, microagglutination test (MAT), Leptospira genus-specific PCR, the IS1500 PCR for identification of pathogenic species, and 16S based sequencing for the genus identification. CONCLUSION:Immunosuppressed patients may acquire uncommon infections from ubiquitous microorganisms. In this case, serology evidence of exposure to Leptospira serovar Bratislava by MAT and the presence of the Leptospira genus were identified. It should be on mind for the diagnosis in otherwise healthy patients, and thoroughly search on splenectomised patients exposed to animals. Additionally, this report highlights the usefulness of PCR for diagnosis of this potentially life-threatening illness.
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最新影响因子:3.667 | 期刊ISSN:1471-2334 | CiteScore:2.86 |
出版周期:Irregular | 是否OA:YES | 出版年份:2001 |
自引率:4.70% | 研究方向:医学-传染病学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published by BioMed Central. ISSN: 1471-2334. BMC Infectious Diseases publishes original research articles in all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases, as well as related molecular genetics, pathophysiology, and epidemiology.
由生物医学中心出版。ISSN: 1471 - 2334。 BMC传染病在传染病和性传播疾病的预防、诊断和管理,以及相关的分子遗传学、病理生理学和流行病学的所有方面发表原创研究文章。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
INFECTIOUS DISEASES (传染病学) 3区 |
44/88 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
794 | 746 | 48 |
引文计数(2018)
文献(2015-2017)
6069次引用
2124篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Infectious Diseases
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#64/266
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研究方向:免疫
审稿时间: 6个月内 接受率: 比较困难(25%命中)
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接受率: 一般容易(75%命中)
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研究方向:感染
审稿时间: 3个月内 接受率: 中等(50%命中)
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研究方向:肝病 免疫
审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:感染与免疫
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研究方向:肺损伤 缺血缺氧脑病
审稿时间: 2个月内 接受率: 一般容易(75%命中)
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审稿时间: 3个月内 接受率: 中等(50%命中)
影响因子:2.762
ISSN:1869-0327
研究方向:MEDICAL INFORMATICS-
影响因子:3.298
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研究方向:医学-医学:信息
影响因子:2.749
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研究方向:医学-卫生保健
影响因子:4.947
ISSN:2291-5222
研究方向:-
影响因子:2.934
ISSN:1460-4582
研究方向:HEALTH CARE SCIENCES & SERVICES-MEDICAL INFORMATIC
影响因子:4.92
ISSN:0148-5598
研究方向:医学-卫生保健
影响因子:3.082
ISSN:1753-8157
研究方向:医学-卫生保健
影响因子:7.076
ISSN:1438-8871
研究方向:医学-卫生保健
影响因子:8
ISSN:1532-0464
研究方向:医学-计算机:跨学科应用
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