Leptospirosis in an asplenic patient -case report.

Abstract:
BACKGROUND:The presentation of clinical leptospirosis has been historically associated with animal workers, slaughterhouse workers and medical veterinarians. This association has shifted to be related to flooding events and outdoor activities; few cases are related to high-risk factors found in immunosuppressed patients. Scarcely a handful of cases have serological evidence of immune response against Leptospira serovar Bratislava representing serogroup Australis, a serovar associated with poor reproductive performance in swine and horses, and recently with cats. CASE PRESENTATION:Herein, we describe a rare clinical presentation of disseminated Leptospira infection in an immunosuppressed 65-year-old woman. She was admitted to the emergency room with fever, bacteraemia, bilateral uveitis and pulmonary involvement. The patient denied outdoor activities; she only had wide exposure to faeces and urine from cats living in her home. Her medical history included idiopathic thrombocytopenic purpura (ITP) diagnosed at the age of 18. She did not respond to medical treatment, and a splenectomy was performed. At age 60, she was diagnosed with Chronic Myeloid Leukemia (CML), and was treated with a tyrosine kinase inhibitor (TKI) -Imatinib. The patient voluntarily discontinued the treatment for the last 6 months. After extensive workup, no microorganisms were identified by the commonly used stains in microbiology. The diagnosis was performed through dark-field microscopy, microagglutination test (MAT), Leptospira genus-specific PCR, the IS1500 PCR for identification of pathogenic species, and 16S based sequencing for the genus identification. CONCLUSION:Immunosuppressed patients may acquire uncommon infections from ubiquitous microorganisms. In this case, serology evidence of exposure to Leptospira serovar Bratislava by MAT and the presence of the Leptospira genus were identified. It should be on mind for the diagnosis in otherwise healthy patients, and thoroughly search on splenectomised patients exposed to animals. Additionally, this report highlights the usefulness of PCR for diagnosis of this potentially life-threatening illness.
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BMC INFECTIOUS DISEASES
BMC INFECT DIS
最新影响因子:3.667 | 期刊ISSN:1471-2334 | CiteScore:2.86 |
出版周期:Irregular | 是否OA:YES | 出版年份:2001 |
自引率:4.70% | 研究方向:医学-传染病学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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BMC INFECTIOUS DISEASES 期刊简介
英文简介:
Published by BioMed Central. ISSN: 1471-2334. BMC Infectious Diseases publishes original research articles in all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases, as well as related molecular genetics, pathophysiology, and epidemiology.
中文简介:(来自Google、百度翻译)
由生物医学中心出版。ISSN: 1471 - 2334。 BMC传染病在传染病和性传播疾病的预防、诊断和管理,以及相关的分子遗传学、病理生理学和流行病学的所有方面发表原创研究文章。
BMC INFECTIOUS DISEASES 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
医学 |
INFECTIOUS DISEASES(传染病) 3区 |
44/88 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
794 | 746 | 48 |
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BMC INFECTIOUS DISEASES 期刊CiteScore评价数据
最新CiteScore值
引文计数(2018)
文献(2015-2017)
6069次引用
2124篇文献
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序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Infectious Diseases
|
#64/266
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liting7111
杂志审稿周期太长了,根不是讲的两到三周!2020-06-16 -
liting7111
研究方向:免疫
审稿时间: 6个月内 接受率: 比较困难(25%命中)
审稿速度特别慢,投稿4个月要求大修,提了25个问题,修回后等了两个半月,提了7个问题,要求小修,不知道猴年马月才能接收,总之就是慢慢慢!2020-06-07 -
liting7111
投稿系统改版了?显示 Please note, this journal now uses Editorial Manager for submission and peer review. Therefore, until further notice any manuscripts submitted or reviewed through Editorial Manager will not be included in the display below. Please go to https://www.editorialmanager.com/infd to track and manage those manuscripts. 用之前的账户密码登录说无此用户,怎么办?2020-03-13 -
liting7111
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liting7111
投稿一个月都显示with editor,发邮件咨询后,状态改为under review。过了四个月还是这个状态,再次发邮件询问,又拖了一个月被退稿了,理由是找不到合适的审稿人2020-01-18 -
liting7111
建议想投稿的,可以进入杂志官网,点击易发表的文章,在右侧找到pre-publication,可以找到改文章各个升高细节和时间。审稿基本都是一身意见要三个月才能回复,半年才能发表。2020-01-08 -
liting7111
催了两次稿,第一次回复在于编辑沟通,之后没有回复了。第二次再次催稿,直接没回复了。速度太慢!2019-11-22 -
liting7111
为什么啊!我在4月14日投的,两天后under review,今天显示decision making,看来是要被拒的节奏啊。2019-09-27 -
liting7111
研究方向:感染
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投稿终于被接受了,编辑处理稿件很细致,从刚接收到后面的修改格式,付版面费恨不得再折腾几次,只能说老外严谨起来,程度令人咋舌。2019-08-04 -
liting7111
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投稿后在编辑部待了两个星期,之后审稿一个月被拒了,其中一个审稿人提了很多细节修改的问题,另外一个直接拒了,第一次投稿感觉还是经验欠缺,有很多不足,不过重在改进,大家加油呀~2019-07-10 -
liting7111
这种杂志不要投!去年8月投稿,今年8月返修,要求大修,修回返回二修意见,要求再修。修个毛,等了这么久,果断撤稿了。2019-07-09 -
liting7111
研究方向:感染与免疫
投稿过去快两个月了,还卡在initial assessment,不知道哪年才有结果。2019-06-09 -
liting7111
研究方向:肺损伤 缺血缺氧脑病
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希望审稿速度能快点!2019-05-02 -
liting7111
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liting7111
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