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Abstract:
:Autism is a neuropathology characterized by behavioral disorders. Considering that oxidative stress is involved in the pathophysiology of this disease, we evaluated the effects of quercetin, a flavonoid with antioxidant and neuroprotective properties, in an experimental model of autism induced by valproic acid (VPA). Twelve pregnant female rats were divided into four groups (control, quercetin, VPA, VPA+quercetin). Quercetin (50 mg/kg) was administered orally to the animals from gestational days 6.5 to 18.5, and VPA (800 mg/kg) was administered orally in a single dosage on gestational day 12.5. Behavioral tests such as open field, social interaction, and tail flick nociceptive assays were performed on pups between 30 and 40 days old, after which the animals were euthanized. Cerebral cortex, hippocampus, striatum, and cerebellum were collected for evaluation of oxidative stress parameters. The pups exposed to VPA during the gestational period showed reduced weight gain, increased latency in the open field and tail flick tests, reduced time of social interaction, accompanied by changes in oxidative stress parameters mainly in the hippocampus and striatum. Prenatal treatment with quercetin prevented the behavioral changes and damage caused by oxidative stress, possibly due to its antioxidant action. Our findings demonstrated that quercetin has neuroprotective effects in an animal model of autism, suggesting that this natural molecule could be an important therapeutic agent for treatment of autism spectrum disorders.
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he journal publishes results of original research on both basic and clinical aspects of the developing nervous system, ranging from simpler invertebrate systems and in vitro neural models to models of regeneration, chronic neurological diseases and aging. Papers concerned with both in vitro and in vivo studies are invited for editorial consideration. The journal will also publish original articles, editorials, reviews and communications from the International Society for Developmental Neuroscience covering all the latest developments in the field. Its main aims will be to facilitate the transfer of basic information to clinical applications and to promote an understanding of the fundamental mechanisms of neural growth, development and pathology. Those interested in joining the International Society for Developmental Neuroscience should write to Dr ReginoPerez-Polo, Secretary-General of the ISDN, at the Department of Human Biological Chemistry and Genetics, UTMB Galveston, TX 77555-0652, U.S.A. Fax: 409 772 8028, e-mail: jperezpo@mspol.med.utmb.edu
该杂志发表了关于神经系统发育的基础和临床方面的原始研究成果,从简单的无脊椎动物系统和体外神经模型到再生模型、慢性神经疾病和衰老模型。有关体外和体内研究的论文请考虑编辑。该杂志还将发表来自国际发展神经科学学会的原创文章、社论、评论和通讯,涵盖该领域的所有最新进展。其主要目的将是促进基本信息向临床应用的转移,并促进对神经生长、发育和病理的基本机制的理解。有意加入国际发展神经科学学会的人士,请致函美国UTMB Galveston大学人类生物化学与遗传学系ISDN秘书长ReginoPerez-Polo博士,传真:409 772 8028,电子邮件:jperezpo@mspol.med.utmb.edu
大类(学科) | 小类(学科) | 学科排名 |
医学 |
DEVELOPMENTAL BIOLOGY (发育生物学) 3区 NEUROSCIENCES (神经科学) 4区 |
19/42 169/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
74 | 66 | 8 |
引文计数(2018)
文献(2015-2017)
766次引用
311篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Developmental Neuroscience
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#14/33
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2 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Developmental Biology
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#35/76
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影响因子:2.566
ISSN:0739-7240
研究方向:农林科学-奶制品与动物科学
影响因子:6.497
ISSN:1172-7047
研究方向:医学-精神病学
影响因子:1.297
ISSN:0028-2804
研究方向:医学-精神病学
影响因子:4.604
ISSN:1092-8529
研究方向:医学-精神病学
影响因子:5.345
ISSN:1398-5647
研究方向:医学-精神病学
影响因子:3.492
ISSN:1540-2002
研究方向:CLINICAL NEUROLOGY-PSYCHIATRY
影响因子:4.562
ISSN:0269-8811
研究方向:医学-精神病学
影响因子:6.533
ISSN:0165-0327
研究方向:医学-精神病学
影响因子:5.415
ISSN:0924-977X
研究方向:医学-精神病学
发表一篇学和医学成像类SCI论文
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