发表一篇学和医学成像类SCI论文
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Abstract:
:Short chain fatty acids, produced as gut microbiome metabolites but also present in diet, exert broad effects in host physiology. Propionic acid (PPA), along with butyrate and acetate, plays a growing role in health, but also in neurological conditions. Increased PPA exposure in humans, animal models and cell lines elicit diverse behavioral and biochemical changes consistent with organic acidurias, mitochondrial disorders and autism spectrum disorders (ASD). ASD is considered a disorder of synaptic dysfunction and cell signaling, but also neuroinflammatory and neurometabolic components. We examined behavior (Morris water and radial arm mazes) and the ultrastructure of the hippocampus and medial prefrontal cortex (electron microscopy) following a single intraperitoneal (i.p.) injection of PPA (175 mg/kg) in male adolescent rats. PPA treatment showed altered social and locomotor behavior without changes in learning and memory. Both transient and enduring ultrastructural alterations in synapses, astro- and microglia were detected in the CA1 hippocampal area. Electron microscopic analysis showed, PPA treatment significantly decreased total number of synaptic vesicles, presynaptic mitochondria and synapses with a symmetric active zone. Thus, brief systemic administration of this dietary and enteric short chain fatty acid produced behavioral and dynamic brain ultrastructural changes, providing further validation of the PPA model of ASD.
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he journal publishes results of original research on both basic and clinical aspects of the developing nervous system, ranging from simpler invertebrate systems and in vitro neural models to models of regeneration, chronic neurological diseases and aging. Papers concerned with both in vitro and in vivo studies are invited for editorial consideration. The journal will also publish original articles, editorials, reviews and communications from the International Society for Developmental Neuroscience covering all the latest developments in the field. Its main aims will be to facilitate the transfer of basic information to clinical applications and to promote an understanding of the fundamental mechanisms of neural growth, development and pathology. Those interested in joining the International Society for Developmental Neuroscience should write to Dr ReginoPerez-Polo, Secretary-General of the ISDN, at the Department of Human Biological Chemistry and Genetics, UTMB Galveston, TX 77555-0652, U.S.A. Fax: 409 772 8028, e-mail: jperezpo@mspol.med.utmb.edu
该杂志发表了关于神经系统发育的基础和临床方面的原始研究成果,从简单的无脊椎动物系统和体外神经模型到再生模型、慢性神经疾病和衰老模型。有关体外和体内研究的论文请考虑编辑。该杂志还将发表来自国际发展神经科学学会的原创文章、社论、评论和通讯,涵盖该领域的所有最新进展。其主要目的将是促进基本信息向临床应用的转移,并促进对神经生长、发育和病理的基本机制的理解。有意加入国际发展神经科学学会的人士,请致函美国UTMB Galveston大学人类生物化学与遗传学系ISDN秘书长ReginoPerez-Polo博士,传真:409 772 8028,电子邮件:jperezpo@mspol.med.utmb.edu
大类(学科) | 小类(学科) | 学科排名 |
医学 |
DEVELOPMENTAL BIOLOGY (发育生物学) 3区 NEUROSCIENCES (神经科学) 4区 |
19/42 169/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
74 | 66 | 8 |
引文计数(2018)
文献(2015-2017)
766次引用
311篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Developmental Neuroscience
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#14/33
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2 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Developmental Biology
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#35/76
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影响因子:2.293
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研究方向:医学-动物学
发表一篇学和医学成像类SCI论文
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