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Abstract:
:Background: Warts are prevalent human papilloma virus (HPV) infections which can cause physical and psychological problems. Candida antigen immunotherapy is a safe and promising treatment of warts. Toll-like receptors (TLR) 2 &4 gene polymorphisms are implicated in susceptibility and progression of several diseases.Aim: To assess the role TLR2Arg753GLN & TLR4Asp299Gly polymorphisms in susceptibility to HPV wart infections and their possible effect on response to Candida antigen immunotherapy.Patients and methods: A total of 78 patients and 78 healthy subjects were enrolled in this case control study. The Polymerase Chain Reaction- Restriction Fragment Length Polymorphism (PCR-RFLP) technique was used to detect TLR2Arg753GLN & TLR4Asp299Gly genes polymorphisms. Patients' lesions were injected with Candida antigens and the response was assessed.Results: The mutant AA and GG genotypes of TLR2Arg753GLN & TLR4Asp299Gly were significantly detected in patients than controls (P < 0.001& P = 0.01, respectively). Intralesional Candida antigen injections achieved complete and partial clearance in 62.8 &20.5% of lesions, respectively. No association was found between the studied polymorphisms and response to Candida antigen injections.Conclusions: TLR2Arg753GLN & TLR4Asp299Gly polymorphisms are associated with susceptibility to wart infections, but with no effect on their response to Candida immunotherapy.
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SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Journal of Dermatological Treatment covers all aspects of the treatment of skin disease, including the use of topically and systemically administered drugs and other forms of therapy. With its focus on treatment and full-colour illustrations, the journal is of immense practical value to the clinical dermatologist and all those concerned with improving the management of skin disease.
《皮肤治疗杂志》涵盖了皮肤疾病治疗的所有方面,包括局部和系统用药以及其他治疗形式。以治疗和全彩插图为重点,该杂志具有巨大的实用价值的临床皮肤科医生和所有有关改善皮肤疾病的管理。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
DERMATOLOGY (皮肤病学) 3区 |
25/64 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
123 | 98 | 25 |
引文计数(2018)
文献(2015-2017)
632次引用
359篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Dermatology
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#39/130
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影响因子:0.549
ISSN:0025-6544
研究方向:医学-力学
影响因子:1.59
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研究方向:地学天文-地球化学与地球物理
影响因子:0
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研究方向:物理-工程:机械
影响因子:4.761
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研究方向:工程技术-工程:机械
影响因子:2.633
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研究方向:工程技术-工程:机械
影响因子:2.04
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研究方向:ACOUSTICS-ENGINEERING, AEROSPACE
影响因子:0.632
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研究方向:ACOUSTICS-ENGINEERING, MECHANICAL
影响因子:1.701
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研究方向:工程技术-工程:机械
影响因子:2.446
ISSN:0021-8464
研究方向:工程技术-材料科学:综合
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