Effects of intestinal alkaline phosphatase on intestinal barrier function in a cecal ligation and puncture (CLP)-induced mouse model for sepsis.

Abstract:
BACKGROUND:Sepsis is a severe pathological condition associated with systemic inflammation, intestinal inflammation, and gastrointestinal barrier dysfunction. Intestinal alkaline phosphatase (IAP) has been demonstrated to detoxify lipopolysaccharide, an important mediator in the pathophysiology of sepsis. We investigated the effect of treatment with IAP on intestinal permeability, intestinal inflammation, and bacterial translocation. METHODS:OF-1 mice were divided into 4 groups (n = 12/group), undergoing either a sham or cecal ligation and puncture (CLP) procedure to induce sepsis. Mice received IAP or a vehicle intraperitoneally 5 minutes prior to the onset of the CLP or sham procedure, which was repeated every 12 hours for two consecutive days. After two days, in vivo intestinal permeability, intestinal inflammation, and bacterial translocation were determined. KEY RESULTS:CLP-induced sepsis resulted in significantly more weight loss, worse clinical disease scores, bacterial translocation, and elevated inflammatory cytokines. Intestinal permeability was increased up to 5-fold (P < .001). IAP activity was significantly increased in septic animals. Treatment with IAP had no effect on clinical outcomes but reduced the increased permeability of the small intestine by 50% (P = .005). This reduction in permeability was accompanied by a modified gene expression of claudin-1 (P = .025), claudin-14 (P = .035), and interleukin 12 (P = .015). A discriminant analysis showed that treatment with IAP is linked to modified mRNA levels of several tight junction proteins and cytokines. CONCLUSIONS AND INFERENCES:Treatment with IAP diminished CLP-induced intestinal barrier disruption, associated with modified expression of several cytokines and claudins. Nevertheless, this effect did not translate into better clinical outcomes in our experimental setup.
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NEUROGASTROENTEROLOGY AND MOTILITY
NEUROGASTROENT MOTIL
最新影响因子:3.96 | 期刊ISSN:1350-1925 | CiteScore:4.14 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1994 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2982
自引率:16.00% | 研究方向:医学-临床神经学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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NEUROGASTROENTEROLOGY AND MOTILITY 期刊简介
英文简介:
Official Journal of the European Society of Neurogastroenterology and Motility. The Journal publishes original research and review articles, abstracts of symposia, meeting reports and book reviews. Neurogastroenterology and Motility encourages papers on all basic and clinical aspects of gastrointestinal motility and its control by myogenic, neural and chemical mechanisms. Papers on the way motility interacts with other gastrointestinal functions including absorption, secretion and immunology are also encouraged.
中文简介:(来自Google、百度翻译)
欧洲神经胃肠病学和运动学会官方期刊。该期刊发表原创研究和评论文章、专题讨论会摘要、会议报告和书评。神经胃肠病学和动力鼓励所有的基础和临床方面的论文胃肠动力及其控制由肌原性,神经和化学机制。关于动力与其他胃肠功能相互作用的论文,包括吸收,分泌和免疫学也被鼓励。
NEUROGASTROENTEROLOGY AND MOTILITY 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
医学 |
CLINICAL NEUROLOGY(临床神经病学) 2区 GASTROENTEROLOGY & HEPATOLOGY(肠胃学和肝脏学) 3区 NEUROSCIENCES(神经系统科学) 3区 |
45/197 23/80 80/261 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
213 | 187 | 26 |
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NEUROGASTROENTEROLOGY AND MOTILITY 期刊CiteScore评价数据
最新CiteScore值
引文计数(2018)
文献(2015-2017)
2520次引用
608篇文献
CiteScore排名
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Physiology
|
#24/169
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|
2 |
大类(学科):Neuroscience
小类(学科):Endocrine and Autonomic Systems
|
#6/24
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|
|
3 |
大类(学科):Medicine
小类(学科):Gastroenterology
|
#9/128
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|
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最新评论(不代表本站观点)
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liting7111
研究方向:消化病 胃肠道
审稿时间: 1个月内
审稿速度挺快,2015年11月25号投的,一个月后被拒稿但是附上了审稿人大量建议,建议很中肯且仔细!2020-05-09 -
liting7111
研究方向:儿科 消化
审稿时间: 2个月内 接受率: 比较困难(25%命中)
六月底投稿,八月底拒稿,2位审稿人提出的建议都很专业,杂志对实验要求高!2020-03-25 -
liting7111
审稿时间: 4个月内
杂志审阅人很公正和专业,对实验的要求比较高!9月投稿一篇,10月就给了major revision,12月修回,1月份就接收了,编辑处理速度也很快!2019-11-25 -
liting7111
研究方向:医药科学 消化系统 胃肠道免疫相关疾病
审稿时间: 1个月内 接受率: 一般容易(75%命中)
审稿速度快,审稿意见仔细很中肯2019-08-02 -
liting7111
研究方向:胃肠动力 应激
接受率: 比较困难(25%命中)
投了个很符合杂志方向的文章,没想到几天就被拒了,说不适合他们杂志,直接没送审。 换了一本2.7的,投稿到接收耗时一个月。 个人感觉这本对实验方法要求高!2019-03-21
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NEUROGASTROENTEROLOGY AND MOTILITY 投稿经验
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