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Controlled release of adenosine from core-shell nanofibers to promote bone regeneration through STAT3 signaling pathway.
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Abstract:
:Adenosine (Ade) has been identified to stimulate bone formation. However, the use of Ade is severely limited by the accompanying side effects and its very short half-life in vivo. This study aimed to fabricate an efficient drug-delivery system to reduce the undesirable side effects and enable the clinical application of Ade for treating large bone defects. The fabricated poly(ε-caprolactone) (PCL)/Ade-polyvinyl alcohol (PVA)(0.3/0.4) nanofibrous mats with 0.3:0.4 (w/w) ratio of Ade and PVA showed a sustained and controlled release of Ade and facilitated the osteogenic differentiation of bone mesenchymal progenitor cells (BMSCs). A larger amount of newly formed bone was observed in vivo in the cranial defects of the PCL/Ade-PVA(0.3/0.4) group compared with those of the non-loaded PCL/PVA nanofibrous mats at 4 and 8 weeks after surgery. Moreover, it is the first time to confirm that Ade mediates the osteogenesis of rat BMSCs through the STAT3 signaling pathway and restrains the osteoclastogenesis of rat bone-marrow macrophages (BMMs). These results suggested that this coaxial drug-delivery system loaded with Ade provided a promising and clinically relevant platform to controlled-release Ade and address large bone defects.
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JOURNAL OF CONTROLLED RELEASE
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| 出版地区： |
SCI期刊coverage：Science Citation Index Expanded（科学引文索引扩展）
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JOURNAL OF CONTROLLED RELEASE 期刊简介
英文简介：
The journal publishes papers on the science and technology of the controlled release and delivery of drugs and other agents. The terms "controlled release" and "delivery" are used in their broadest sense to include mechanisms such as diffusion, chemical and enzymatic reactions, dissolution, osmosis, targeting, and the utilization and manipulation of biological processes. A broad spectrum of papers dealing with all aspects of controlled release and delivery, including gene delivery, tissue engineering and diagnostic agents, is encouraged. The use of prodrugs and carriers such as water-soluble polymers, micro- and nanoparticles, liposomes and micelles is included in the scope. Relevant papers on the toxicology and biocompatibility of drug delivery systems are also published. In addition to original full length papers, notes, reviews and rapid communications, the journal includes book reviews, reports of future meetings, and announcements pertaining to the activities of the Controlled Release Society.
中文简介：（来自Google、百度翻译）
该杂志发表了关于药物和其他制剂的控释和交付的科学和技术论文。术语“控制释放”和“传递”在广义上包括扩散、化学和酶反应、溶解、渗透、靶向以及生物过程的利用和操作等机制。鼓励发表涉及控释和释放所有方面的广泛论文，包括基因释放、组织工程和诊断试剂。前药和载体的使用，如水溶性聚合物，微和纳米颗粒，脂质体和胶束包括在范围内。还发表了有关药物给药系统毒理学和生物相容性的相关论文。除了原稿、笔记、评论和快速通讯外，该杂志还包括书评、关于未来会议的报告和有关管制发行协会活动的公告。
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JOURNAL OF CONTROLLED RELEASE 期刊中科院评价数据
最新中科院分区
| 大类(学科) | 小类(学科) | 学科排名 |
| 医学 |
PHARMACOLOGY & PHARMACY (药学) 2区 CHEMISTRY, MULTIDISCIPLINARY (化学综合) 1区 |
23/171 9/261 |
最新公布的期刊年发文量
| 年度总发文量 | 年度论文发表量 | 年度综述发表量 |
| 479 | 394 | 85 |
总被引频次：47630
特征因子：0.052240
影响因子趋势图
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JOURNAL OF CONTROLLED RELEASE 期刊CiteScore评价数据
最新CiteScore值
7.9
=
引文计数(2018)
文献(2015-2017)
=
12605次引用
1596篇文献
文献总数（2014-2016）：1596
被引比率：91%
SJR：2.684
SCLmago期刊等级衡量经过加权后的期刊受引用次数，引用次数的加权值由施引期刊的学科领域和声望(SJR)决定。
SNIP：1.802
每篇文章中来源出版物的标准化影响将实际受引用情况对照期刊所属学科领域中预期的受引用情况进行衡量。
CiteScore排名
| 序号 | 类别 | 排名 | 百分位 |
| 1 |
大类(学科)：Pharmacology, Toxicology and Pharmaceutics
小类(学科)：Pharmaceutical Science
|
#4/174
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