发表一篇学和医学成像类SCI论文
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Abstract:
:Myeloid-derived suppressor cells(MDSCs)are one of the most important immunosuppressive cells in tumor microenvironment, which also promote the development and progression of tumor cells. Nevertheless, due to the different distribution features of MDSCs and tumor cells, selective elimination of MDSCs and tumor cells in tumor microenvironment remain a great challenge. Here we have designed a dual-pH-sensitivity conjugated micelle system (PAH/RGX-104@PDM/PTX) that could deliver liver-X nuclear receptor (LXR) agonist RGX-104 and paclitaxel (PTX) to the perivascular region and tumor cells, respectively. Upon arrival at the acidic tumor microenvironment, the PAH/RGX-104@PDM/PTX undergo structure disintegration and capacitate coinstantaneous release of RGX-104 in the perivascular regions, leaving the intact PTX containing micelles PDM/PTX for tumor deep penetration. The released RGX-104 can be preferentially taken up by leukocytes, endothelial cells and macrophages which are nicely enriched in perivascular regions to active the LXR, and further reduces immunosuppressive MDSC levels. The remained small micelles carrying PTX enable deep tumor penetration as well as rapid specific drug release in the endosomal/lysosomal to kill tumor cells. PAH/RGX-104@PDM/PTX exhibits superior tumor accumulation as well as tumor penetration, and suppresses 74.88% in vivo tumor growth. More importantly, PAH/RGX-104@PDM/PTX has significantly alleviated tumor immunosuppression by eliminating MDSCs and increasing cytotoxic T lymphocytes infiltration. Our studies suggest that the dual-pH-sensitive codelivery nanocarrier not only cause apoptosis of cancer cells but also regulate the tumor immune environment to ultimately enhance the antitumor effect of CTLs through MDSCs depletion.
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SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The journal publishes papers on the science and technology of the controlled release and delivery of drugs and other agents. The terms "controlled release" and "delivery" are used in their broadest sense to include mechanisms such as diffusion, chemical and enzymatic reactions, dissolution, osmosis, targeting, and the utilization and manipulation of biological processes. A broad spectrum of papers dealing with all aspects of controlled release and delivery, including gene delivery, tissue engineering and diagnostic agents, is encouraged. The use of prodrugs and carriers such as water-soluble polymers, micro- and nanoparticles, liposomes and micelles is included in the scope. Relevant papers on the toxicology and biocompatibility of drug delivery systems are also published. In addition to original full length papers, notes, reviews and rapid communications, the journal includes book reviews, reports of future meetings, and announcements pertaining to the activities of the Controlled Release Society.
该杂志发表了关于药物和其他制剂的控释和交付的科学和技术论文。术语“控制释放”和“传递”在广义上包括扩散、化学和酶反应、溶解、渗透、靶向以及生物过程的利用和操作等机制。鼓励发表涉及控释和释放所有方面的广泛论文,包括基因释放、组织工程和诊断试剂。前药和载体的使用,如水溶性聚合物,微和纳米颗粒,脂质体和胶束包括在范围内。还发表了有关药物给药系统毒理学和生物相容性的相关论文。除了原稿、笔记、评论和快速通讯外,该杂志还包括书评、关于未来会议的报告和有关管制发行协会活动的公告。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
PHARMACOLOGY & PHARMACY (药学) 2区 CHEMISTRY, MULTIDISCIPLINARY (化学综合) 1区 |
23/171 9/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
479 | 394 | 85 |
引文计数(2018)
文献(2015-2017)
12605次引用
1596篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Pharmaceutical Science
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#4/174
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影响因子:2.438
ISSN:0261-1929
研究方向:农林科学-兽医学
影响因子:3.025
ISSN:1094-7159
研究方向:医学-临床神经学
影响因子:4.169
ISSN:0264-410X
研究方向:医学-免疫学
影响因子:17.579
ISSN:0022-1007
研究方向:医学-免疫学
影响因子:5.274
ISSN:0971-5916
研究方向:医学-免疫学
影响因子:4.061
ISSN:2314-6745
研究方向:ENDOCRINOLOGY & METABOLISM-MEDICINE, RESEARCH & EX
影响因子:2.976
ISSN:0914-8779
研究方向:医学-内分泌学与代谢
影响因子:4.75
ISSN:0141-8955
研究方向:医学-内分泌学与代谢
影响因子:10.171
ISSN:1931-5244
研究方向:医学-医学:内科
发表一篇学和医学成像类SCI论文
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