发表一篇学和医学成像类SCI论文
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Abstract:
:Gene therapy has gathered vast interest and been proved promising and prospective. While gene therapy evolves fast, demands of high transfecting efficiency and less toxic gene vectors are not sufficiently fulfilled. The progression of materials is doing the favor from which therapeutic application benefited is helping reshape treatments of cancer. In this work, we synthesized fluorinated branched polyethylenimine (PF33) and RGD-R8-PEG-HA (RRPH). When mixed with plasmids, the PF33 could form a compact nanoparticle PFC (Fluorinated PEI/plasmid Complex) and showed high transfection efficiency (>70% in A549 cells). Peptide modification and PEGylation on HA constituted the RRPH, and coating on the PFC would enable the ultimate nanoparticle RRPHC (RRPH coating PFC Complex) achieve long-term circulation and tumor tissue-penetration while maintaining the high transfection efficiency of PFC. Observations about the behavior in cellular organisms of RRPHC revealed its nucleus-targeting tendency. The in vivo distribution images revealed the RRPHC nanoparticles, compared to HAC (HA coated PFC, used as control) could achieve extended accumulation specifically on tumor regions rather than stay in other organs. While loaded with plasmids encoding our rationally designed trojan Apoptin (pSTA), RRPHC could establish compounds for the massive production of membrane-penetrating protein. Hence these cancer-killing proteins would charge at nucleus once phosphorylated and finish the task of destruction. Both in vitro and in vivo treatment using RRPHC/pSTA nanoparticles resulted in remarkable tumor suppression and the cytotoxicity tests demonstrated its low toxicity. In summary, pSTA encapsulating RRPHC nanoparticles may have potential applications in cancer gene therapy.
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SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The journal publishes papers on the science and technology of the controlled release and delivery of drugs and other agents. The terms "controlled release" and "delivery" are used in their broadest sense to include mechanisms such as diffusion, chemical and enzymatic reactions, dissolution, osmosis, targeting, and the utilization and manipulation of biological processes. A broad spectrum of papers dealing with all aspects of controlled release and delivery, including gene delivery, tissue engineering and diagnostic agents, is encouraged. The use of prodrugs and carriers such as water-soluble polymers, micro- and nanoparticles, liposomes and micelles is included in the scope. Relevant papers on the toxicology and biocompatibility of drug delivery systems are also published. In addition to original full length papers, notes, reviews and rapid communications, the journal includes book reviews, reports of future meetings, and announcements pertaining to the activities of the Controlled Release Society.
该杂志发表了关于药物和其他制剂的控释和交付的科学和技术论文。术语“控制释放”和“传递”在广义上包括扩散、化学和酶反应、溶解、渗透、靶向以及生物过程的利用和操作等机制。鼓励发表涉及控释和释放所有方面的广泛论文,包括基因释放、组织工程和诊断试剂。前药和载体的使用,如水溶性聚合物,微和纳米颗粒,脂质体和胶束包括在范围内。还发表了有关药物给药系统毒理学和生物相容性的相关论文。除了原稿、笔记、评论和快速通讯外,该杂志还包括书评、关于未来会议的报告和有关管制发行协会活动的公告。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
PHARMACOLOGY & PHARMACY (药学) 2区 CHEMISTRY, MULTIDISCIPLINARY (化学综合) 1区 |
23/171 9/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
479 | 394 | 85 |
引文计数(2018)
文献(2015-2017)
12605次引用
1596篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Pharmaceutical Science
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#4/174
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影响因子:2.566
ISSN:0739-7240
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研究方向:医学-精神病学
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影响因子:3.492
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研究方向:CLINICAL NEUROLOGY-PSYCHIATRY
影响因子:4.562
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研究方向:医学-精神病学
影响因子:6.533
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研究方向:医学-精神病学
影响因子:5.415
ISSN:0924-977X
研究方向:医学-精神病学
发表一篇学和医学成像类SCI论文
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