发表一篇学和医学成像类SCI论文
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Abstract:
:This work describes the neuropharmacological (sedative, anxiolytic, antidepressant, and anticonvulsant) actions of Gardenin A (GA) (0.1-25 mg/kg p.o.), a flavonoid found in medicinal plants. The sedative effects of GA were assessed with the pentobarbital-induced sleep test. The anxiolytic actions of GA were evaluated with the elevated plus-maze, the light-dark box test, the exploratory cylinder assay, and the open field test. Motor coordination was evaluated with the rotarod test and the open field test. The antidepressant-like actions of GA were evaluated with the tail suspension test and forced swimming test. The mechanisms of the anxiolytic-like and antidepressant-like effects of GA were assessed using inhibitors of neurotransmission pathways. The anticonvulsant activity of GA was evaluated with the strychnine-induced seizure test. The sedative effects of GA were evident only at a dose of 25 mg/kg, which increased the duration of sleep but did not alter sleep onset. GA showed anxiolytic-like actions with activity comparable to that of clonazepam in all experimental tests. The GABAA receptor antagonist bicuculline reversed the anxiolytic-like effects of GA. Furthermore, GA showed significant antidepressant-like actions in both models with activity comparable to that of fluoxetine. Yohimbine, an α2-adrenoceptor blocker, inhibited the antidepressant-like actions of GA. In addition, GA (1-10 mg/kg) did not affect locomotor coordination in mice and delayed the onset of convulsions. These findings suggest that GA induces anxiolytic-like effects and has anticonvulsant actions by the possible involvement of the GABAergic system. The antidepressant-like actions of GA may be mediated by noradrenergic neurotransmission.
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SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on medicinal chemistry pharmacology biotechnology and biopharmaceuticals toxicology and drug delivery formulation and pharmacokinetics. The journal welcomes manuscripts on new compounds and technologies in all areas focused on human therapeutics as well as global management health care policy and regulatory issues involving the drug discovery and development process. In addition to full-length articles Drug Development Research publishes Brief Reports on important and timely new research findings as well as in-depth review articles. The journal also features periodic special thematic issues devoted to specific compound classes new technologies and broad aspects of drug discovery and development.
药物开发研究集中于与新治疗实体的发现和开发相关的研究主题。该杂志发表关于药物化学、药理学、生物技术和生物制药毒理学以及药物传递制剂和药代动力学的原创研究文章。该杂志欢迎所有领域的新化合物和新技术的手稿,这些领域的重点是人类疗法以及涉及药物发现和开发过程的全球管理、卫生保健政策和监管问题。除了全文文章,药物开发研究还发表关于重要和及时的新研究结果的简要报告以及深入的综述文章。该杂志还定期出版专题专题,专门讨论特定的化合物类、新技术和药物发现与开发的广泛方面。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
CHEMISTRY, MEDICINAL (药物化学) 3区 PHARMACOLOGY & PHARMACY (药学) 3区 |
27/59 124/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
39 | 38 | 1 |
引文计数(2018)
文献(2015-2017)
384次引用
182篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Drug Discovery
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#67/150
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影响因子:1.696
ISSN:0174-304X
研究方向:医学-临床神经学
影响因子:4.21
ISSN:0887-8994
研究方向:医学-临床神经学
影响因子:2.363
ISSN:0883-0738
研究方向:医学-临床神经学
影响因子:3.042
ISSN:1071-9091
研究方向:CLINICAL NEUROLOGY-PEDIATRICS
影响因子:3.692
ISSN:1090-3798
研究方向:医学-临床神经学
影响因子:4.864
ISSN:0012-1622
研究方向:医学-临床神经学
影响因子:9.703
ISSN:0031-4005
研究方向:医学-小儿科
影响因子:5.106
ISSN:1661-7800
研究方向:医学-小儿科
影响因子:2.567
ISSN:1471-2431
研究方向:PEDIATRICS-
发表一篇学和医学成像类SCI论文
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