
发表一篇学和医学成像类SCI论文
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Abstract:
:Simulated microgravity can significantly affect various cell types and multiple systems of the human body, such as cardiovascular system, skeletal muscle system, and immune system, and is known to cause anemia and loss of electrolyte and fluids. Epidermal stem cells (EpSCs) were cultured in a rotary cell culture system (RCCS) bioreactor to simulate microgravity. The metabolites of EpSCs were identified by liquid chromatography-mass spectrometry (LC-MS). Compared with normal gravity (NG) group, a total of 57 different metabolites of EpSCs were identified (P < 0.05, VIP > 1), including lipids and lipid-like molecules (51 molecules), amino acids (5 molecules), nucleosides, nucleotides, and analogues (1 molecule). According to the partial least squares discriminant analysis (PLS-DA) score plot, a VIP > 1 and P < 0.05 were obtained for the 57 different metabolites, of which 23 molecules were significantly downregulated and 34 were significantly upregulated in simulated microgravity (SMG) group. These results showed that SMG has a significant impact on different pathways, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated that multiple pathways were involved, mainly the amino acid metabolism pathway, lipid metabolism pathway, membrane transport pathway, and cell growth and death pathways. Thus, the metabolic profile of EpSCs was changed under SMG. Exploring the metabolic profile of EpSCs would be helpful to further understand the growth characteristics of EpSCs under SMG, which will provide a new approach to explore the metabolomics mechanism of stress injury and repair trauma under SMG.
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最新影响因子:1.665 | 期刊ISSN:1071-2690 | CiteScore:N/A |
出版周期:Bimonthly | 是否OA:YES | 出版年份:0 |
期刊官方网址:http://www.springer.com/life+sciences/cell+biology/journal/11626
自引率:5.70% | 研究方向:生物-发育生物学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Founded in 1965, In Vitro Cellular & Developmental Biology - Animal remains unique in its focus on in vitro biology in animals. This peer-reviewed journal reports results of research in cellular, molecular, and developmental biology that employ or are relevant to organs, tissue, tumors, and cells in vitro. Coverage includes biotechnology; cell and tissue models; cell growth, differentiation, apoptosis; cellular pathology/virology; cytokines/growth factors/adhesion factors; signal transduction; toxicology/chemical carcinogenesis; product applications and more. With its high-caliber original research and reviews, In Vitro Cellular & Developmental Biology - Animal benefits everyone who needs to keep up-to-date on the latest developments and state-of-the-art research in animal cell and tissue culture and biotechnology from around the world. A journal of the Society for In Vitro Biology (SIVB).
成立于1965年,在体外细胞和发育生物学-动物仍然是独特的,其重点在体外生物学的动物。本同行评审的杂志报告了细胞、分子和发育生物学的研究结果,这些研究采用或与体外器官、组织、肿瘤和细胞相关。覆盖范围包括生物技术;细胞和组织模型;细胞生长、分化、凋亡;细胞病理学/病毒学;细胞因子和生长因子/粘附的因素;信号转导;毒理学/化学致癌;产品应用和更多。 其高水平的原始研究和评论,在体外细胞和发育生物学-动物受益的每一个人都需要保持最新的发展和最先进的研究动物细胞和组织培养和生物技术从世界各地。 体外生物学会(SIVB)期刊。
大类(学科) | 小类(学科) | 学科排名 |
生物 |
CELL BIOLOGY(细胞生物学) 4区 DEVELOPMENTAL BIOLOGY(发育生物学) 4区 |
172/190 36/42 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
104 | 99 | 5 |
引文计数(2018)
文献(2015-2017)
N/A次引用
N/A篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Toxicology
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