Upregulated lncRNA UCA1 inhibits trophoblast cell invasion and proliferation by downregulating JAK2.

Abstract:
:Numerous studies have suggested that urothelial cancer-associated 1 (UCA1) acts as a suppressor gene affecting cell proliferation and migration. However, the biological role and the potential mechanism of UCA1 in the progression of pre-eclampsia (PE) remains unclear. The UCA1 level was markedly upregulated in PE pregnancies relative to non-PE ones in GSE75010 and tissues. A higher body mass index (BMI), maximum systolic blood pressure (BP), and maximum diastolic BP were observed in PE pregnancies, whereas the newborn weight z-score was lower compared with those of non-PE pregnancies. Knockdown of UCA1 accelerated the proliferative migratory abilities and cell cycle progression, but inhibited apoptosis of HTR-8/SVneo and JAR cells. Then, we found that Janus kinases 2 (JAK2) was negatively correlated with UCA1. In addition, JAK2 was downregulated in the placenta of PE pregnancies and was negatively regulated by UCA1. UCA1 was mainly enriched in the nucleus. Knockdown of UCA1 reduced the occupancies of the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and H3K27me3 on the Janus kinase 2 (JAK2) promoter regions. Finally, rescue experiments found that transfection of short-hairpin JAK2 attenuated proliferative and migratory abilities of trophoblasts, which were partially reversed after UCA1 knockdown. In short, UCA1 is upregulated in the trophocytes of PE pregnancies and accelerates trophoblast cell invasion and proliferation by downregulating JAK2.
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JOURNAL OF CELLULAR PHYSIOLOGY
J CELL PHYSIOL
最新影响因子:6.513 | 期刊ISSN:0021-9541 | CiteScore:3.7 |
出版周期:Monthly | 是否OA:YES | 出版年份:1966 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4652
自引率:3.20% | 研究方向:生物-生理学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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JOURNAL OF CELLULAR PHYSIOLOGY 期刊简介
英文简介:
The Journal of Cellular Physiology publishes reports of high biological significance in all areas of eukaryotic cell biology and physiology focusing on those articles which adopt a molecular mechanistic approach to investigate cell biology. In particular the journal actively encourages the submission of high-interest papers investigating the regulation of growth and differentiation by growth factors and cytokines signal transduction by growth factors cytokines and their cognate receptors and the conditions which influence the expression and function these molecules. Similarly the journal actively encourages the submission of manuscripts exploring the regulation of growth and differentiation by cell adhesion molecules as well as the interplay between these processes and those induced by growth factors and cytokines. Studies on the genes and processes that regulate cell cycle progression and phase transition in eukaryotic cells and the mechanisms which determine whether cells enter quiescence proliferation or undergo apoptosis are also welcomed. Finally the investigation of the basic changes which differentiate cancer cells from normal cells including studies on the properties and functions of oncogenes and tumor suppressor genes will remain as one of the major interests of the Journal.
中文简介:(来自Google、百度翻译)
细胞生理学杂志在真核细胞生物学和生理学的所有领域发表了具有高生物学意义的报告,重点关注那些采用分子机制方法研究细胞生物学的文章。特别是该期刊积极鼓励提交高利益论文,通过生长因子和细胞因子信号转导生长因子细胞因子及其同源受体以及影响这些分子表达和功能的条件来研究生长和分化的调节。同样,该期刊积极鼓励提交手稿,探讨细胞粘附分子对生长和分化的调节,以及这些过程与生长因子和细胞因子诱导的过程之间的相互作用。研究调节真核细胞中细胞周期进程和相变的基因和过程以及确定细胞是否进入静止增殖或经历细胞凋亡的机制也受到欢迎。最后,研究区分癌细胞与正常细胞的基本变化,包括对致癌基因和肿瘤抑制基因的性质和功能的研究,仍将是该杂志的主要兴趣之一。
JOURNAL OF CELLULAR PHYSIOLOGY 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
医学 |
CELL BIOLOGY(细胞生物学) 3区 PHYSIOLOGY(生理学) 2区 |
73/190 13/83 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
371 | 289 | 82 |
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JOURNAL OF CELLULAR PHYSIOLOGY 期刊CiteScore评价数据
最新CiteScore值
引文计数(2018)
文献(2015-2017)
3079次引用
832篇文献
CiteScore排名
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Physiology
|
#31/169
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|
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2 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Clinical Biochemistry
|
#18/118
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|
3 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Cell Biology
|
#84/264
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|
|
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