Influence of the integrin alpha-1 subunit and its relationship with high-fat diet upon extracellular matrix synthesis in skeletal muscle and tendon

Abstract:
Integrins are important for mechanosensation in tissue and play, together with nutrition, a role in regulating extracellular matrix (ECM) in skeletal muscle and tendon. Integrin receptors are dimers that consist of an α and β subunit and bridge extracellular and intracellular signals. The present study investigates whether the deletion of the integrin receptor α_1 subunit influences collagen and other matrix proteins in the musculotendinous tissue and whether it causes any compensatory changes in other integrin subunits in C57BL/6J mice. In addition, we study whether a high-fat diet (HFD) influences these responses in muscle or tendon. Mice on a HFD had a higher number of non-enzymatic cross-links in skeletal muscle ECM and increased gene expression of collagen and other extracellular matrix proteins. In contrast to gene expression, total collagen protein content was decreased by HFD in the muscle with no change in tendon. Integrin α_1 subunit knockout resulted in a decrease of collagen type I and III, TGF-β1 and IGF-1 gene expression in muscle of HFD mice but did not affect total collagen protein compared with wild-type (WT) littermates in either muscle or tendon. There was no compensatory increase in the genes that express other integrin subunits. In conclusion, HFD induced a significant increase in expression of ECM genes in muscle. On the protein level, HFD resulted in a lower collagen content in muscle. Tendons were unaffected by the diet. Deletion of the integrin α_1 subunit did not affect collagen protein or gene expression in muscle or tendon.
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CELL AND TISSUE RESEARCH
CELL TISSUE RES
最新影响因子:4.051 | 期刊ISSN:0302-766X | CiteScore:3.04 |
出版周期:Monthly | 是否OA:YES | 出版年份:1974 |
期刊官方网址:http://www.springer.com/biomed/human+genetics/journal/441
自引率:2.10% | 研究方向:生物-细胞生物学 |
出版地区:GERMANY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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CELL AND TISSUE RESEARCH 期刊简介
英文简介:
Cell and Tissue Research presents regular articles and reviews in the areas of molecular, cell, and supracellular biology. In particular, the journal provides a forum for publishing data that analyze the supracellular, integrative actions of gene products and their impact on the formation of tissue structure and function. Articles emphasize structure-function relationships as revealed by recombinant molecular technologies. Areas of research with a long-standing tradition of publishing in Cell & Tissue Research include: neurobiology, neuroendocrinology, endocrinology, reproductive biology, skeletal and immune systems, and development.
中文简介:(来自Google、百度翻译)
细胞和组织研究在分子、细胞和细胞上生物学领域提出了定期的文章和评论。特别是,该杂志为发表数据提供了一个论坛,分析基因产物的超细胞、整合作用及其对组织结构和功能形成的影响。文章强调重组分子技术揭示的结构-功能关系。在细胞和组织研究方面有着悠久的发表传统的研究领域包括:神经生物学、神经内分泌学、内分泌学、生殖生物学、骨骼和免疫系统以及发育。
CELL AND TISSUE RESEARCH 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
生物 |
CELL BIOLOGY(细胞生物学) 4区 |
107/190 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
191 | 128 | 63 |
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最新CiteScore值
引文计数(2018)
文献(2015-2017)
2272次引用
748篇文献
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序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Pathology and Forensic Medicine
|
#24/185
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2 |
大类(学科):Medicine
小类(学科):Histology
|
#12/61
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3 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Cell Biology
|
#122/264
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