发表一篇学和医学成像类SCI论文
需要多少钱?
Abstract:
:Immune checkpoint blockade (ICB) therapies have revolutionized the treatment of human cancers including lung adenocarcinoma (LUAD). However, our understanding of the immune subtyping of LUAD and its association with clinical response of immune checkpoint inhibitor remains incomplete. Here we performed molecular subtyping and association analysis of LUAD from the Cancer Genome Atlas (TCGA) and validated findings from TCGA cohort in 9 independent validation cohorts. We conducted consensus molecular subtyping with nonnegative matrix factorization (NMF). Potential response of ICB therapy was estimated with Tumor Immune Dysfunction and Exclusion (TIDE) algorithm. We identified 2 distinct subtypes of LUAD in TCGA cohort that were characterized by significantly different survival outcomes (i.e., high- and low-risk subtypes). The high-risk subtype was featured by lower TIDE score, upregulation of programmed death-ligand 1 (PD-L1) expression, and higher tumor mutation burden (TMB). The high-risk subtype also harbored significantly elevated cell cycle modulators CDK4/CDK6 and TP53 mutation. These observations were validated in 9 independent LUAD cohorts. Our findings suggest that immune checkpoint blockade therapy may be efficacious for high-risk subtype of LUAD patients.
展开更多
最新影响因子:5.955 | 期刊ISSN:1945-4589 | CiteScore: |
出版周期:Monthly | 是否OA:YES | 出版年份:2008 |
期刊官方网址:http://www.aging-us.com/
期刊投稿地址:http://aging.msubmit.net/
自引率:7.40% | 研究方向:CELL BIOLOGY- |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
专业编辑在线一对一答疑及时解决您的问题
Aging-US
老龄化
大类(学科) | 小类(学科) | 学科排名 |
医学 |
CELL BIOLOGY (细胞生物学) 2区 GERIATRICS & GERONTOLOGY (老年医学) 2区 |
48/190 5/53 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
149 | 146 | 3 |
引文计数(2018)
文献(2015-2017)
次引用
篇文献
序号 | 类别 | 排名 | 百分位 |
推荐刊物均可到国家新闻出
版总署网站查询正刊
可签署保密协议 ,不透露任
何用户信息可跟踪进程,全程
协议
1对1服务,7x24小时在线
15年经验沉淀,实体公司
运营
影响因子:43.474
ISSN:1074-7613
研究方向:医学-免疫学
影响因子:2.957
ISSN:0891-6934
研究方向:医学-免疫学
影响因子:3.152
ISSN:0171-2985
研究方向:医学-免疫学
影响因子:4.04
ISSN:1750-743X
研究方向:医学-免疫学
影响因子:3.594
ISSN:1471-2172
研究方向:医学-免疫学
影响因子:2.211
ISSN:0198-8859
研究方向:医学-免疫学
影响因子:31.25
ISSN:1529-2908
研究方向:医学-免疫学
影响因子:4.23
ISSN:0165-2478
研究方向:医学-免疫学
影响因子:8.701
ISSN:1933-0219
研究方向:医学-免疫学
发表一篇学和医学成像类SCI论文
需要多少钱?
专注医学期刊服务15年
您好:请问您咨询什么等级的期刊?专注医学类期刊发表15年口碑企业,为您提供以下服务:
1.医学核心期刊发表-全流程服务
2.医学SCI期刊-全流程服务
3.论文投稿服务-快速报价
4.期刊推荐直至录用,不成功不收费
客服正在输入...
Aging-US 投稿经验
(由下方点评分析获得,0人参与,82231人阅读)