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Abstract:
BACKGROUND:The correlation between superoxide dismutase 2 (SOD2) V16A variant and urological cancer susceptibility has been widely studied, however, with divergent results. RESULTS:Totally, 9,910 cancer patients and 11,239 control subjects were enrolled. V16A variant is associated with an increased susceptibility to urological cancer (A-allele vs. V-allele: OR = 1.06, 95% CI = 1.00 - 1.13, P = 0.047; AA+AV vs. VV: OR = 1.09, 95% CI = 1.02 - 1.16, P = 0.008), especially for prostate cancer (PCa). Serum SOD2 level of PCa patients with VV+VA genotypes was lower than in those with AA genotypes. SOD2 expression is downregulated in both prostate and bladder cancer, as compared to the control. Furthermore, SOD2 was found to be downregulated in more advanced PCa participants, as compared to the ones in early stages. PCa subjects with low SOD2 expression displayed a shorter disease-free survival (DFS) time compared to that of the high SOD2 expression counterparts. CONCLUSIONS:The SOD2 V16A variant may be associated with increased urological cancer susceptibility, especially for prostate cancer. METHODS:A pooled analysis utilizing odds ratios (ORs), in silico tools and ELISA was adopted to demonstrate this association. We also used immunohistochemical staining (IHS) to assess SOD2 expression.
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最新影响因子:5.955 | 期刊ISSN:1945-4589 | CiteScore: |
出版周期:Monthly | 是否OA:YES | 出版年份:2008 |
期刊官方网址:http://www.aging-us.com/
期刊投稿地址:http://aging.msubmit.net/
自引率:7.40% | 研究方向:CELL BIOLOGY- |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Aging-US
老龄化
大类(学科) | 小类(学科) | 学科排名 |
医学 |
CELL BIOLOGY (细胞生物学) 2区 GERIATRICS & GERONTOLOGY (老年医学) 2区 |
48/190 5/53 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
149 | 146 | 3 |
引文计数(2018)
文献(2015-2017)
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发表一篇学和医学成像类SCI论文
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