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Effect of One-Year Growth Hormone Therapy on Cardiometabolic Risk Factors in Boys with Obesity.
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Abstract:
It has been recognized that people with obesity are more likely to have low growth hormone secretion. Recent studies have also confirmed that the abnormalities of the growth hormone/insulin-like growth factor 1 axis were associated with cardiovascular complications in people with obesity. However, little is known about whether recombinant human growth hormone therapy could improve cardiovascular and metabolic risks in obese children. This study aims to evaluate the effect of one-year growth hormone therapy on obesity-related comorbidities and to assess the safety in Chinese boys with obesity. Eighteen boys with obesity were treated with recombinant human growth hormone for one year. Anthropometric measurements, endocrine testing, and cardiovascular risk markers were performed in all obese boys in baseline, and follow-up visits were performed at 3 months, 6 months, 9 months, and one year, respectively. After one year of recombinant human growth hormone treatment, the body mass index standard deviation scores decreased (P < 0.001) and insulin-like growth factor 1 levels increased (P < 0.001). GH treatment also reduced low density lipoprotein cholesterol (P < 0.001), total cholesterol (P < 0.001), triglycerides (P=0.042), and alanine aminotransferase (P=0.027) when compared with the baseline. One-year of recombinant human growth hormone treatment could improve cardiometabolic risk markers, without adverse effects on glucose homeostasis in boys with obesity.
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Biomed Research International
BIOMED RES INT
| 最新影响因子：3.246 | 期刊ISSN：2314-6133 | CiteScore：2.55 |
| 出版周期： | 是否OA：YES | 出版年份：0 |
| 自引率：2.50% | 研究方向：BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RES |
| 出版地区：UNITED STATES |
SCI期刊coverage：Science Citation Index Expanded（科学引文索引扩展）
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Biomed Research International 期刊简介
英文简介：
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas. BioMed Research International is archived in Portico, which provides permanent archiving for electronic scholarly journals, as well as via the LOCKSS initiative. It operates a fully open access publishing model which allows open global access to its published content. This model is supported through Article Processing Charges. For more information on Article Processing charges in general, click here. BioMed Research International is included in many leading abstracting and indexing databases. For a complete list, click here. BioMed Research International was founded in 2001 by Professor Abdelali Haoudi who served as the Editor-in-Chief of the journal between 2001 and 2008. The most recent Impact Factor for BioMed Research International is 2.583 according to the 2017 Journal Citation Reports released by Clarivate Analytics in 2018. The journal’s most recent CiteScore is 2.55 according to the CiteScore 2017 metrics released by Scopus.
中文简介：（来自Google、百度翻译）
《国际生物医学研究》是一份经过同行评审的开放获取期刊，发表原创研究文章、综述文章和临床研究，涵盖生命科学和医学的广泛主题。该杂志分为55个主题领域。 国际生物医学研究中心(BioMed Research International)在Portico存档，它为电子学术期刊以及LOCKSS计划提供永久存档。它运行一个完全开放的访问发布模型，允许对其发布的内容进行开放的全局访问。这个模型是通过文章处理费来支持的。有关一般文章处理费的更多信息，请点击这里。 国际生物医学研究组织被收录在许多领先的文摘和索引数据库中。点击这里查看完整列表。 国际生物医学研究由Abdelali Haoudi教授于2001年创立，他在2001年至2008年间担任该杂志的主编。 根据Clarivate Analytics在2018年发布的2017年期刊引文报告，国际生物医学研究的最新影响因素是2.583。根据Scopus发布的CiteScore 2017指标，《华尔街日报》最新的CiteScore指数为2.55。
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Biomed Research International 期刊中科院评价数据
最新中科院分区
| 大类(学科) | 小类(学科) | 学科排名 |
| 医学 |
BIOTECHNOLOGY & APPLIED MICROBIOLOGY (生物工程与应用微生物) 3区 MEDICINE, RESEARCH & EXPERIMENTAL (医学：研究与实验) 4区 |
66/161 71/133 |
最新公布的期刊年发文量
| 年度总发文量 | 年度论文发表量 | 年度综述发表量 |
| 1927 | 1629 | 298 |
总被引频次：36776
特征因子：0.109840
影响因子趋势图
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Biomed Research International 期刊CiteScore评价数据
最新CiteScore值
2.55
=
引文计数(2018)
文献(2015-2017)
=
22946次引用
8990篇文献
文献总数（2014-2016）：8990
被引比率：72%
SJR：0.935
SCLmago期刊等级衡量经过加权后的期刊受引用次数，引用次数的加权值由施引期刊的学科领域和声望(SJR)决定。
SNIP：0.984
每篇文章中来源出版物的标准化影响将实际受引用情况对照期刊所属学科领域中预期的受引用情况进行衡量。
CiteScore排名
| 序号 | 类别 | 排名 | 百分位 |
| 1 |
大类(学科)：Biochemistry, Genetics and Molecular Biology
小类(学科)：General Biochemistry, Genetics and Molecular Biology
|
#50/187
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|
|
| 2 |
大类(学科)：Immunology and Microbiology
小类(学科)：General Immunology and Microbiology
|
#14/39
点击查看排名表
|
|
CiteScore趋势图
Scopus涵盖范围
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