Assessing the progression of gastric cancer via profiling of histamine, histidine, and bile acids in gastric juice using LC-MS/MS.

Abstract:
:Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Moreover, the progression of gastric cancer, could change the gut microbiome, including bacteria spp. that produce secondary BAs. Gastric juice has various metabolites that could indicate gastric cancer-related stomach conditions. Therefore, profiling of HIST, His, and BAs in gastric juice is crucial for understanding the etiological mechanisms of gastric cancer. We used a profiling method to simultaneously determine targeted metabolites in gastric juice using liquid chromatography-tandem mass spectrometry (LC-MS/MS). We successfully analyzed 70 human gastric juice samples from patients with chronic superficial gastritis (CSG, n = 20), intestinal metaplasia (IM, n = 12), and gastric cancer (n = 38). Furthermore, we investigated the relevance between BA metabolism and gastric cancer. There were statistical differences in the metabolism of cholic acid (CA) into deoxycholic acid (DCA) based on the progression of CSG into IM and gastric cancer. Hence, the progression of gastric cancer might be related to the alterations in gut microbiome composition. We provide insight into the etiological mechanisms of the progression of gastric cancer and biomarkers to diagnose and treat gastric cancer.
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JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
J STEROID BIOCHEM
最新影响因子:5.011 | 期刊ISSN:0960-0760 | CiteScore:3.81 |
出版周期:Monthly | 是否OA:YES | 出版年份:1990 |
期刊官方网址:http://www.journals.elsevier.com/the-journal-of-steroid-biochemistry-and-molecular-biology/
自引率:7.50% | 研究方向:生物-内分泌学与代谢 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 期刊简介
英文简介:
The Journal of Steroid Biochemistry and Molecular Biology is devoted to new experimental or theoretical developments in areas related to steroids. It publishes original papers as well as general and mini-reviews, proceedings of selected meetings and rapid communications (brief highly-topical articles of particular interest).The journal covers a wide range of topics relating to steroids:- Molecular, cellular, and physiological actions of steroid hormones, steroid anti-hormones and their analogs via regulation of gene expression or other mechanisms. Structure, function, regulation, and cell biology of receptors of the steroid-thyroid-retinoid superfamily. Cross-talk between steroids, steroid receptors and other signal transduction pathways. Steroids and cell proliferation, regulation of cell cycle genes. Steroid transport. Steroids and cancer: functional relationships in normal and neoplastic tissues between steroid hormones and cytokines, growth factors, growth inhibitors, and oncogenes. Steroids and cancer prevention. Biosynthesis, secretion, and metabolism of steroids and of biologically-related compounds, and their regulation by peptide hormones, prostaglandins and other substances. Molecular aspects of enzymes involved in steroidogenesis. Novel therapeutic applications of new steroid agonists or antagonists. Steroids and neuroendocrinology or neuroimmunology. Neurosteroids, steroid action on synactic transmission and modulation. Steroid hormones and hypertension. Steroids and their actions on bone and on the cardiovascular systems. Steroid enzyme inhibitors. Steroids and analogs in menopause. Steroids in hormone replacement therapy. Steroid hormones in osteoporosis: basic and clinical applications. Steroids and contraception. Defects in steroid metabolism. Steroid hormones during pregnancy, development and sex differentiation. Structure, physicochemical, chemical and pharmacological characteristics of natural and synthetic steroids and related compounds of biological interest. Innovative techniques relating to steroids and biologically-related substances. Clinical and physiological studies of inborn or acquired changes of biosynthesis, metabolism or action of steroids and their receptors. Comparative endocrinology and evolution of steroids. Environmental effects on steroid metabolism and action.
中文简介:(来自Google、百度翻译)
甾体生物化学和分子生物学杂志致力于甾体相关领域的新的实验或理论发展。它出版原始论文以及一般和小型评论、选定会议的记录和快速通讯(特别感兴趣的高度专题的简要文章)。该杂志涵盖了广泛的主题有关类固醇:分子,细胞,和生理活动的类固醇激素,类固醇抗激素及其类似物通过调控基因表达或其他机制。甾体-甲状腺-维甲酸超家族受体的结构、功能、调控及细胞生物学。甾体、甾体受体及其他信号转导途径的交叉对话。类固醇与细胞增殖,调节细胞周期基因。类固醇运输。类固醇与癌症:类固醇激素与细胞因子、生长因子、生长抑制因子及癌基因在正常及肿瘤组织中的功能关系。类固醇和癌症预防。类固醇和生物相关化合物的生物合成、分泌和代谢,以及它们受肽激素、前列腺素和其他物质的调节。参与类固醇生成的酶的分子方面。新型类固醇激动剂或拮抗剂的新治疗应用。类固醇和神经内分泌学或神经免疫学。神经甾体,甾体对合乳酸传递和调节的作用。类固醇激素和高血压。类固醇及其对骨骼和心血管系统的作用。类固醇酶抑制剂。更年期类固醇和类似物。激素替代疗法中的类固醇。类固醇激素在骨质疏松症:基础和临床应用。类固醇和避孕。类固醇代谢缺陷。类固醇激素在怀孕期间,发育和性别分化。天然和合成类固醇及其相关生物活性化合物的结构、理化、化学和药理特性。类固醇和生物相关物质的创新技术。类固醇及其受体的生物合成、代谢或作用的先天或后天变化的临床和生理学研究。比较内分泌学和类固醇的进化。环境对类固醇代谢和作用的影响。
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
医学 |
BIOCHEMISTRY & MOLECULAR BIOLOGY(生物化学和分子生物学) 2区 ENDOCRINOLOGY & METABOLISM(内分泌学和新陈代谢) 2区 |
69/293 32/142 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
270 | 212 | 58 |
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JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 期刊CiteScore评价数据
最新CiteScore值
引文计数(2018)
文献(2015-2017)
2585次引用
679篇文献
CiteScore排名
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Endocrinology, Diabetes and Metabolism
|
#32/209
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|
|
2 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Biochemistry
|
#78/402
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|
|
3 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Molecular Medicine
|
#35/161
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|
|
4 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Molecular Biology
|
#94/366
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|
|
5 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Endocrinology
|
#21/119
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|
|
6 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Clinical Biochemistry
|
#16/118
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|
7 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Cell Biology
|
#79/264
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|
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