Resting-state fMRI Detects Alterations in Whole Brain Connectivity Related to Tumor Biology in Glioma Patients.
切换为中文
Abstract:
BACKGROUND:Systemic infiltration of the brain by tumor cells is a hallmark of glioma pathogenesis which may cause disturbances in functional connectivity. We hypothesized that aggressive high-grade tumors cause more damage to functional connectivity than low-grade tumors. METHODS:We designed an imaging tool based on resting-state functional MRI to individually quantify abnormality of functional connectivity and tested it in a prospective cohort of patients with newly diagnosed glioma. RESULTS:34 patients (WHO II: 13; WHO III: 6; WHO IV: 15; mean age 48,7 years) were analyzed. Connectivity abnormality could be observed not only in the lesioned brain area but also in the contralateral hemisphere with a close correlation between connectivity abnormality and aggressiveness of the tumor as indicated by WHO grade. IDH 1 mutation status was also associated with abnormal connectivity, with more alterations in IDH 1 wildtype tumors independent of tumor size. Finally, deficits in neuropsychological performance were correlated with connectivity abnormality. CONCLUSIONS:Here, we suggested an individually applicable resting-state fMRI marker in glioma patients. Analysis of the functional connectome using this marker revealed that abnormalities of functional connectivity could be detected not only adjacent to the visible lesion but also in distant brain tissue, even in the contralesional hemisphere. These changes were associated with tumor biology and cognitive function. The ability of our novel method to capture tumor effects in non-lesional brain suggests a potential clinical value for both individualizing and monitoring glioma therapy.
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NEURO-ONCOLOGY
NEURO-ONCOLOGY
| 最新影响因子：13.029 | 期刊ISSN：1522-8517 | CiteScore：6.76 |
| 出版周期：Quarterly | 是否OA：YES | 出版年份：1999 |
| 自引率：6.80% | 研究方向：医学-临床神经学 |
| 出版地区：UNITED STATES |
SCI期刊coverage：Science Citation Index Expanded（科学引文索引扩展）
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NEURO-ONCOLOGY 期刊简介
英文简介：
Neuro-Oncology provides high-quality and rapid publication of information in all areas of neuro-oncology. A truly international publication, it encourages participation from a wide array of subspecialties and geographic locations. The journal contains peer-reviewed articles and reviews, symposia on selected topics, published abstracts of annual meetings, and society news and announcements.
中文简介：（来自Google、百度翻译）
神经肿瘤学提供高质量和快速出版的信息在所有领域的神经肿瘤学。它是一份真正的国际出版物，鼓励来自各个子专业和地理位置的广泛参与。该杂志包括同行评审的文章和评论，选定主题的专题讨论会，发表的年会摘要，以及社会新闻和公告。
NEURO-ONCOLOGY 期刊中科院评价数据
最新中科院分区
| 大类(学科) | 小类(学科) | 学科排名 |
| 医学 |
CLINICAL NEUROLOGY(临床神经病学) 1区 ONCOLOGY(肿瘤学) 2区 |
9/197 15/223 |
最新公布的期刊年发文量
| 年度总发文量 | 年度论文发表量 | 年度综述发表量 |
| 154 | 138 | 16 |
影响因子趋势图
NEURO-ONCOLOGY 期刊CiteScore评价数据
最新CiteScore值
引文计数(2018)
文献(2015-2017)
4402次引用
651篇文献
CiteScore排名
| 序号 | 类别 | 排名 | 百分位 |
| 1 |
大类(学科)：Medicine
小类(学科)：Oncology
|
#15/325
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|
|
| 2 |
大类(学科)：Medicine
小类(学科)：Neurology (clinical)
|
#8/336
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|
|
| 3 |
大类(学科)：Biochemistry, Genetics and Molecular Biology
小类(学科)：Cancer Research
|
#12/191
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|
|
CiteScore趋势图
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最新评论(不代表本站观点)
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liting7111
研究方向：肿瘤 分子
杂志偏临床，下面是我投稿到接受时间： 15年5月19 submit 15年6月12 major revision 15年9月4 re-submit 15年9月22 conditionally accept with minor revision 15年9月30 re-re-submit 10月19 accept2020-05-26 -
liting7111
研究方向：肿瘤 癌症
Neuro-Oncology is the leading journal in its field, ranked above all other neuro-oncology journals by Thomson’s ISI Web of Knowledge Journal Citation Report. Dedicated to providing superior and rapid publication of information in all areas of neuro-oncology, the journal contains peer-reviewed articles and reviews, symposia on selected topics, published abstracts of annual meetings, and society news and announcements from around the world.2020-02-24 -
liting7111
研究方向：肿瘤
风格有点像肿瘤内的caner research 和 oncogene，估计影响因子还会再涨！2019-09-06 -
liting7111
研究方向：肿瘤 癌症
神经肿瘤学领域的国际权威杂志，主编由美国MD安德森癌症中心神经肿瘤科主任Alfred W.K. Yung教授担任，2009年Neuro-Oncology转为牛津期刊出版，之前由杜克大学出版社出版，2010年开始该杂志变更为单月刊。2019-06-13
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