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Abstract:
BACKGROUND:The aim of the present study was to compare the effects of milrinone and levosimendan on right ventricular (RV) inotropy and lusitropy in patients after aortic valve replacement (AVR) for aortic stenosis, a procedure in which an abnormal postoperative RV function may be seen. METHODS:In a prospective, blinded trial, 31 patients were randomized to receive either milrinone (0.4 and 0.8 µg/kg/min, n = 16) or levosimendan (0.1 and 0.2 µg/kg/min, n = 15) after AVR for aortic stenosis. RV performance, afterload (pulmonary arterial elastance), RV strain, systolic (SR-S) and early diastolic (SR-E) strain rate were measured by pulmonary artery thermodilution catheterization and transoesophageal two-dimensional speckle tracking echocardiography. To circumvent the indirect effects of inodilator-induced hemodynamic changes on RV systolic and diastolic deformation, pulmonary arterial elastance, central venous pressure and heart rate were maintained constant by atrial pacing, plasma volume expansion with colloids and phenylephrine-induced vasoconstriction during treatment with the inotropes. RESULTS:A dose-dependent increase in stroke volume index and cardiac index by approximately 20% were seen with both agents at the highest doses, with no difference between groups (P = .792 and 0.744, respectively). In both groups, RV strain and SR-S dose-dependently increased by 20% and 15%-19%, respectively, at the highest doses (P = .742 and 0.259, respectively) with no difference between groups. SR-E improved by both agents 20%-24% at the highest dose with no difference between groups (P = .714). CONCLUSIONS:The direct RV inotropic and lusitropic effects of levosimendan and milrinone were comparable at clinically relevant infusion rates.
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最新影响因子:2.274 | 期刊ISSN:0001-5172 | CiteScore:2.25 |
出版周期:Monthly | 是否OA:YES | 出版年份:1957 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1399-6576
自引率:5.30% | 研究方向:医学-麻醉学 |
出版地区:DENMARK |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published by John Wiley and Sons. ISSN (printed): 0001-5172. ISSN (electronic): 1399-6576. Acta Anaesthesiologica Scandinavica publishes papers on original work in
由约翰威利父子出版。ISSN(印刷体):0001-5172。ISSN(电子版):1399-6576。 《麻醉学学报》(Acta Aneustesiologica Scandinavica)于年出版了有关原著的论文。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ANESTHESIOLOGY(麻醉学) 4区 |
19/31 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
127 | 119 | 8 |
引文计数(2018)
文献(2015-2017)
1195次引用
530篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Anesthesiology and Pain Medicine
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研究方向:医学-传染病学
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