发表一篇学和医学成像类SCI论文
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Abstract:
:Tumor invasion and metastasis involve processes in which actin cytoskeleton rearrangement induced by Fascin1 plays a crucial role. Indeed, Fascin1 has been found overexpressed in tumors with worse prognosis. Migrastatin and its analogues target Fascin1 and inhibit its activity. However, there is need for novel and smaller Fascin1 inhibitors. The aim of this study was to assess the effect of compound G2 in colorectal cancer cell lines and compare it to migrastatin in in vitro and in vivo assays. Molecular modeling, actin-bundling, cell viability, inmunofluorescence, migration, and invasion assays were carried out in order to test anti-migratory and anti-invasive properties of compound G2. In addition, the in vivo effect of compound G2 was evaluated in a zebrafish model of invasion. HCT-116 cells exhibited the highest Fascin1 expression from eight tested colorectal cancer cell lines. Compound G2 showed important inhibitory effects on actin bundling, filopodia formation, migration, and invasion in different cell lines. Moreover, compound G2 treatment resulted in significant reduction of invasion of DLD-1 overexpressing Fascin1 and HCT-116 in zebrafish larvae xenografts; this effect being less evident in Fascin1 known-down HCT-116 cells. This study proves, for the first time, the in vitro and in vivo anti-tumoral activity of compound G2 on colorectal cancer cells and guides to design improved compound G2-based Fascin1 inhibitors. KEY MESSAGES: • Fascin is crucial for tumor invasion and metastasis and is overexpressed in bad prognostic tumors. • Several adverse tumors overexpress Fascin1 and lack targeted therapy. • Anti-fascin G2 is for the first time evaluated in colorectal carcinoma and compared with migrastatin. • Filopodia formation, migration activity, and invasion in vitro and in vivo assays were performed. • G2 blocks actin structures, migration, and invasion of colorectal cancer cells as fascin-dependent.
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最新影响因子:5.606 | 期刊ISSN:0946-2716 | CiteScore: |
出版周期:Monthly | 是否OA:YES | 出版年份:1995 |
自引率:2.00% | 研究方向:医学-医学:研究与实验 |
出版地区:GERMANY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Official Organ of the "German Working Group for Gene Therapy (DAG-GT)" Official Organ of the "Biomedical Research Association (KBF)" The employment of molecular biology and gene technology has enhanced the understanding of human diseases creating a new branch of research - that of "molecular medicine". The Journal of Molecular Medicine (JMM) publishes original papers rapid communications review articles and correspondence of the highest quality pertinent to all aspects of human biology and pathophysiology. The application of research involving gene technology gene therapy molecular structural analysis genetic epidemiology and molecular and clinical pharmacology has made unprecedented progress and precision possible in the understanding prevention diagnosis and treatment of human diseases. These areas of molecular medicine therefore will be given particular attention by the editorial board. Papers describing in vitro or animal studies will be accepted if they are relevant to normal or pathological human biology. Please include at the end of the acknowledgements a declaration that the experiments comply with the current laws of the country in which the experiments were performed.
“德国基因治疗工作组”官方机构“生物医学研究协会”官方机构分子生物学和基因技术的应用提高了对人类疾病的认识,创造了一个新的研究分支——“分子医学”。分子医学杂志(JMM)出版与人类生物学和病理生理学有关的所有方面的最高质量的原始论文、快速通讯评论文章和通信。基因技术、基因治疗、分子结构分析、遗传流行病学、分子与临床药理学等方面的研究应用,在认识人类疾病的预防、诊断与治疗方面,取得了前所未有的进展和精度。因此,分子医学的这些领域将受到编辑委员会的特别关注。描述体外或动物研究的论文,如果与正常或病理的人类生物学有关,将被接受。请在确认信的末尾附上一份声明,声明实验符合实验所在国的现行法律。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
GENETICS & HEREDITY (遗传学) 2区 MEDICINE, RESEARCH & EXPERIMENTAL (医学:研究与实验) 2区 |
29/171 20/133 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
117 | 80 | 37 |
引文计数(2018)
文献(2015-2017)
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研究方向:基因治疗 信号通路
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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研究方向:自身免疫 分子机制 细胞凋亡
接受率: 中等(50%命中)
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研究方向:纤维化
liting7111
研究方向:肿瘤 靶向治疗 分子机制
审稿时间: 2个月内
影响因子:2.655
ISSN:1520-9512
研究方向:医学-呼吸系统
影响因子:3.427
ISSN:1027-3719
研究方向:医学-传染病学
影响因子:4.09
ISSN:8755-6863
研究方向:医学-呼吸系统
影响因子:5.526
ISSN:1526-0542
研究方向:医学-呼吸系统
影响因子:2.973
ISSN:1472-9792
研究方向:医学-呼吸系统
影响因子:3.289
ISSN:2055-1010
研究方向:PRIMARY HEALTH CARE-RESPIRATORY SYSTEM
影响因子:10.262
ISSN:0012-3692
研究方向:医学-呼吸系统
影响因子:2.339
ISSN:0020-1324
研究方向:医学-呼吸系统
影响因子:102.642
ISSN:2213-2600
研究方向:RESPIRATORY SYSTEM-RESPIRATORY SYSTEM
发表一篇学和医学成像类SCI论文
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